UNIVERSITY OF PENNSYLVANIA

DEPARTMENT OF BIOENGINEERING

COMPUTATIONAL BIOLOGY RESEARCH GROUP

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Principal Investigator: Ravi Radhakrishnan, PhD.

Assistant Professor of Bioengineering Assistant Professor of Biochemistry and Biophysics Assistant Professor of Chemical & Biomolecular Engineering Graduate Group Member Genomics & Computational Biology Member of Institute for Targeted Medicine and Therapeutics Cheminformatics Core of the Penn Center of Molecular Discovery	University of Pennsylvania Department of Bioengineering 240 Skirkanich Hall, 210 S. 33^rd St. Philadelphia, PA, 19104 Ph: 1 (215) 898 0487; Fax: 1(215) 573 2071 Email: rradhak@seas.upenn.edu		1995 B. Tech. Indian Institute of Technology 2001 PhD Cornell University Postdoctoral Training: 2000-2002 Massachusetts Institute of Technology 2002-2004 New York University and the Courant Institute 2003 Howard Hughes Medical Institute
Molecular Systems Biology through multiscale modeling and high-performance computing Our research interests lie at the interface of chemical physics and molecular biology. Our goal is to provide atomic and molecular level characterization of complex biomolecular systems and formulate quantitatively accurate microscopic models for predicting the interactions of various therapeutic agents with innate biochemical signaling mechanisms. We employ several computational algorithms ranging from techniques to treat electronic structure, molecular dynamics, Monte Carlo simulations, stochastic kinetic equations, and complex systems analyses in conjunction with the theoretical formalisms of statistical and quantum mechanics, and high performance computing in massively parallel architectures. CURRENT RESEARCH PROJECTS DNA Repair & Molecular Carcinogenesis Cancer Therapeutics: Receptor-mediated signaling Drug resistance in receptor tyrosine kinase inhibitors Mechanisms of RNA catalysis and signaling involving RNA molecules Targeted drug delivery: Model-driven design of functional nanocarriers   Signal transduction in biochemical networks		Research Canvas: presentations and movies related to our research Media Coverage		COURSES BE324: Physical Principles in Bioengineering BE559: Multiscale Modeling of Biochemical Systems COMPUTING RESOURCES Dissemination: distribution of software developed Positions Available Undergraduate Research for BE, CBE, PHYS, CHEM, BMB majors CONTACT US with your CV and a brief statement of interest

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