The Chen Lab


Selected Publications

 

77. Sniadecki, N.J., Lamb, C.M., Liu, Y., Chen, C.S., Reich, D.H. (2008) Magnetic Microposts for Mechanical Stimulation of Biological Cells: Fabrication, Characterization, and Analysis. Review of Scientific Instruments. [Epub ahead of print] [PDF]

76. Shen, C.J., Fu, J., Chen, C.S. (2008) Patterning Cell and Tissue Function. Cellular and Molecular Bioengineering. 1: 15-23. [PDF]

75. Alom Ruiz, S., Chen, C.S.(2008) Using Microfabrication to Engineer Cellular and Multicellular Architecture. Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Series: Engineering in Medicine & Biology. Page: 139-159.

74. Pirone D.M., Qi L., Colecraft H., Chen C.S. (2008) Spatial patterning of gene expression using surface-immobilized recombinant adenovirus. Biomed Microdevices. [Epub ahead of print] [PDF]

73. Liu, W.F., Hui, E.E., Bhatia, S.N., Chen, C.S.(2008) Engineering Cellular Microenvironments. Principles of Regenerative Medicine. 1st Ed. Academic Press. Page: 536-553.

72. Fournier, A.K., Campbell, L.E., Castagnino, P, Liu, W.F., Chung, B.M., Weaver, V.M., Chen, C.S., Assoian, R.K. (2008) Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of Cell Science. 121(Pt 2):226-233. [PDF]

71. Chen, C.S. (2008) Remote control of living cells. Nature Nanotechnology. 3: 13-14. [PDF]

70. Liu, W.F., Chen, C.S. (2007) Cellular and multicellular form and function. Adv Drug Deliv Rev. 59: 1319-1328. [PDF]

69. Yang, M.T., Sniadecki, N.J., Chen, C.S. (2007) Geometric Considerations of Micro- to Nanoscale Elastomeric Post Arrays to Study Cellular Traction Forces. Advanced Materials. 19: 3119–3123. [PDF]

68. Gómez-Sjöberg, R., Leyrat, A.A., Pirone, D.M., Chen, C.S., Quake, S.R. (2007) Versatile, Fully Automated, Microfluidic Cell Culture System. Anal Chem. 79: 8557-8563. [PDF]

67. Desai, R.A., Yang, M.T., Sniadecki, N.J., Legant, W.R., Chen, C.S. (2007) Microfabricated Post-Array-Detectors (mPADs): an approach to isolate mechanical force. J Visualized Exp. 7. [HTML]

66. Bhadriraju, K., Yang, M.T., Alom Ruiz, S., Pirone, D.M., Tan, J.L., Chen, C.S. (2007) Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 313: 3616-3623. [PDF]

65. Sniadecki, N.J., Anguelouch, A, Yang, M.T., Lamb, C.M., Liu, Z., Kirschner, S.B., Liu, Y, Reich, D.H., Chen, C.S. (2007) Magnetic microposts as an approach to apply forces to living cells. Proc Nat Acad Sci. 104: 14553-14558. [PDF] [SUP MAT][Press Coverage]

64. Liu, W.F., Nelson, C.M., Tan, J.L., Chen, C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res. 101: e44-e52. [PDF] [SUP MAT]

63. Sniadecki, N.J., Chen, C.S. (2007) Microfabricated Silicone Elastomeric Post Arrays for Measuring Traction Forces of Adherent Cells. In Methods in Cell Biology - Cell Mechanics, Volume 83. (ed. Y-L. Wang and D.E. Discher), Elsevier: New York. 13:313-328. [PDF]

62. Chen, C.S. (2007) Bait and Switch: Synthetic GEFs Divert an Input Signal to Diverse Cellular Responses. Development Cell . 13: 9-10. [PDF]

61. Bhatia, S.N, Chen, C.S. (2007) Special issue on Cell and Tissue Engineering in Microsystems. Lab on a Chip. 7: 666. [PDF]

60. Chen, C.S. (2007) Separate but Not Equal: Differential Mechanical Roles for Myosin Isoforms. Biophys J. 92: 2984-2985. [PDF]

59. Nelson, C.M., Liu, W.F., Chen, C.S. (2007) Manipulation of Cell-Cell Adhesion Using Bowtie-Shaped Microwells. In Methods in Molecular Biology: Adhesion Protein Protocols, 2nd Ed. (ed. A.S. Coutts). Human Press. 270: 1-9. [PDF]

58. Alom Ruiz, S., Chen, C.S. (2007) Microcontact printing: a tool to pattern. Soft Matter. 3(2):168-177. [PDF]

57. Sniadecki, N.J., Chen, C.S. (2006) Instrumentation for Cell Mechanics. In Medical Devices and Systems: The Biomedical Engineering Handbook, Third Edition. (ed. J.D. Bronzino). CRC Press. 65:1-11. [PDF]

56. Vandenberghe, L.H., Wang, L., Somanathan, S., Zhi, Y., Figueredo, J., Calcedo, R., Sanmiguel, J., Desai, R.A., Chen, C.S., Johnston, J., Grant, R.L., Gao G., & Wilson J.M. (2006) Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Medicine. 12(8):967-971. [PDF]

55. Pirone, D.M., Liu, W.F., Gao, L., Raghavan, S., Lemmon, C.A., Romer, L.H., Chen, C.S. (2006) An Inhibitory Role for FAK in Regulating Proliferation: a Link Between Limited Adhesion and RhoA-ROCK Signaling. J Cell Biol. 174(2):277-88. [PDF] [Press Coverage]

54. Liu, W.F., Nelson, C.M., Pirone, D.M., Chen, C.S. (2006) E-cadherin Engagement Stimulates Proliferation Via Rac1. J Cell Biol. 173(3):431-441. [PDF] [SUP FIG]

53. Sniadecki, N.J., Desai, R.A., Alom Ruiz, S., Chen, C.S. (2006) Nanotechnology for Cell-Substrate Interactions. Annals of Biomed Eng. 34(1):59-74. [PDF]

52. Liu, W.F., Chen, C.S. (2005) Engineering biomaterials to control cell function. Materials Today. 12(8):28-35. [PDF]

51. Jean, R., Spector, A., Chen, C.S. (2005) Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model. J Biomech Eng. 127(4):594-600. [PDF]

50. Nelson, C.M., Jean, R.P., Tan, J.L., Liu, W.F., Sniadecki, N.J., Spector, A.A., Chen, C.S., (2005) Emergent patterns of growth contolled by multicellular form and mechanics. Proc Nat Acad Sci. 102(33):11594-11599. [PDF] [SUP FIG] [Press Coverage]

49. Herndon, T.M., Pirone, D.M., Tsokos, G.C., Chen, C.S., (2005) T cell-to-T cell clustering enhances NF-κB activitity by a PI3K signal mediated by Cbl-b and Rho. Biochem Biophys Res Comm. 332:1133-1139. [PDF]

48. Tanase, M., Felton, E.J., Gray, D.S., Hultgren, A., Chen, C.S., Reich, D. (2005) Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab on a Chip. 5:598-605. [PDF]

47. Lemmon, C.A., Sniadecki, N.J., Ruiz, S.A., Tan, J.T., Romer, L.H., Chen, C.S. (2005) Shear Force at the Cell-Matrix Interface: Enhanced Analysis For Microfabricated Post Array Detectors. Mechanics & Chemistry of Biosystems. 2(1):1-16. [PDF]

46. Yim, E.K.F., Reano, R.M., Pang, S.W., Yee, A.F., Chen, C.S., Leong, K.W. (2005) Nanopattern-induced changes in morphology and motility in smooth muscle cells. Biomaterials. 26:54035-5413. [PDF]

45. Chen, C.S., Jiang, X., Whitesides, G.M. (2005) Microengineering the Enviroment of Mammalian Cells in Culture. MRS Bulletin. 30:194-201. [PDF]

44. Wang, A.Y., Mo, X., Chen, C.S., Yu, S.M., (2005) Facile Modification of Collagen Directed by Collagen Mimetic Peptides. J Am Chem Soc. 127(12):4130-4131 [PDF]

43. Hultgren, A., Tanase, M., Felton, E.J., Bhadriraju, K., Salem, A.K., Chen, C.S., Reich, D. (2005) Optimization of Yield in Magnetic Cell Separations Using Nickel Nanowires of Different Lengths. Biotech Prog. 21:509-515. [PDF]

42. Pirone, D.M., Chen, C.S. (2004) Strategies for Engineering the Adhesive Microenviroment. (2004) J Mammary Gland Biol Neoplasia 9(4):405-417. [PDF]

41. Pirone, D.M., Chen, C.S. (2004) Using lab-on-a-chip technologies to understand cellular mechanotransduction. In Lab-On-Chips for Cellomics (ed. H. Anderson, A. van den Berg). Kluwer Academic. 171-196. [PDF]

40. Raghavan, S., Chen, C.S. (2004) Micropatterned environments in cell biology. Adv Mat. 16:1303-1313. [PDF]

39. Chen, C.S., Tan, J.L., Tien, J. (2004) Mechanotransduction at cell-matrix and cell-cell contacts. Ann Rev Biomed Eng. 6:275-302. [PDF]

38. McBeath, R., Pirone, D., Nelson, C.M., Bhadriraju, K., Chen, C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Development Cell. 6:483-495. [PDF] [Press Coverage]

37. Nelson, C.M., Pirone, D., Tan, J.L., Chen, C.S. (2004) VE-cadherin regulates cytoskeletal tension, cell spreading and focal adhesions by stimulating RhoA. Mol Biol Cell. 15:2943-2953. [PDF]

36. Gray, D.S., Tien, J., Chen, C.S. (2003) High conductivity elastomeric electronics. Advanced Materials. 166:393-397. [PDF] [Press Coverage]

35. Birenbaum, N.S. , Lai, B.T., Chen, C.S. , Reich, D.H. and Meyer, G.J. (2003) Selective non-covalent adsorption of protein to bifunctional metallic nanowire surfaces. Langmuir. 19:9580-9582. [PDF]

34. Tan, J.L., Liu, W., Nelson, C.M., Raghavan, S., Chen, C.S. (2004) A simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Engineering. 10:865-872. [PDF]

33. Chen, C.S ., Alonso, J.L., Ostuni, E., Whitesides, G.M., Ingber, D.E. (2003) Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Comm. 307:355-361. [PDF]

32. Reich, D.H., M. Tanase, A. Hultgren, L.A. Bauer, Chen, C.S. , Meyer, G.J. (2003) Biological applications of multifunctional magnetic nanowires. J Appl Phys. 10:7275-7280. [PDF]

31. Jean, R., Gray, D.S, Spector, A., Chen, C.S. (2004) Characterization of the nuclear deformation caused by changes in endothelial cell shape. J Biomech Eng. 126:552-558. [PDF]

30. Gray, D.S., Chen, C.S. (2003) Patterning cells in registration with high fidelity using dielectrophoresis. Biosensors Bioelectronics. 19:771-780. [PDF]

29. Nelson, C.M., Chen, C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem Eng Tech. [PDF Manuscript]

28. Plant, A.L., Chen, C.S., Groves, J.T., Parikh, A.N. (2003) The biomolecular interface. Langmuir. 19:1449-1450. [PDF]

27. Hultgren, A., Tanase, M., Chen, C.S ., Reich, D. (2003) Cell manipulation using magnetic nanowires. J Appl Phys. 10:7554-7556. [PDF]

26. Tan, J.L., Tien, J., Pirone, D., Gray, D.S., Chen, C.S . (2003) Cells lying on a bed of microneedles: An approach to isolate mechanical force. Proc Nat Acad Sci USA. 100:1484-1489. [PDF] [Press Coverage]

25. Nelson, C.M., Chen, C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Science 116:3571-3581. [PDF]

24. Nelson, C.M., Raghavan, S., Tan, J.L., Chen, C.S. (2002) Degradation of micropatterned surfaces by cell-dependent and -independent processes. Langmuir. 9:1493-1499.
[PDF]

23. Gray, D.S., Tien, J., Chen, C.S. (2002) Cell migration on surfaces patterned with differential mechanical compliance. J Biomed Mater Res. 66A(3):605-14. [PDF]

22. Bhadriraju, K., Chen, C.S. (2002) Engineering cellular microenvironments to improve cell-based drug testing. Drug Disc Tod. 7:612-620. [PDF]

21. Nelson, C.M., Chen, C.S. (2002) signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters. 514:238-242. [PDF]

20. Tan, J.L., Tien, J., Chen, C.S. (2002) Microcontact printing of proteins on mixed self-assembled monolayers. Langmuir. 18: 519-523. [PDF]

19. Tien, J., Nelson, C.M., Chen, C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc Nat Acad Sci USA. 99: 1758-1762. [PDF]

18. Tien, J., Chen, C.S. (2001) Patterning the Cellular Microenvironment. IEEE Eng Med Biol. 21:95-97. [PDF]

17. Tien, J., Chen, C.S. (2001) Microarrays of Cells. In Methods of Tissue Engineering (ed. A. Atala, R. Lanza). Academic Press.

16. Ostuni, E., Chen, C.S., Ingber, D.E., Whitesides, G.M. (2001) Selective deposition of proteins and cells in arrays of microwells. Langmuir 17:2828-2834. [PDF]

15. Ostuni, E., Kane, R., Chen, C.S., Ingber, D.E., Whitesides, G.M. (2000) Patterning mammalian cells using elastomeric membranes. Langmuir 16:7811-7819. [PDF]

14. Bhatia, S.N. and Chen, C.S. (1999) Tissue engineering at the microscale. J Biomed Microdevices. 2: 131-144. [PDF]

13. Chen, C.S., Brangwynne, C., Ingber, D.E. (1999) Pictures in cell biology: squaring up to the cell-shape debate. Trends Cell Biol. 9:283. [PDF]

12. Dike, L.E., Chen., C.S., Mrksich, M., Tien, J., Whitesides, G.M., Ingber, D.E. (1999) Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim. 35:441-8. [PDF]

11. Huang, S., Chen, C.S., Ingber, D.E. (1998) Control of cyclin D1, p27Kip1 and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell. 9:3179-93. [PDF]

10. Chen, C.S., Ostuni, E., Whitesides, G.M., Ingber, D.E. (1998) Using self-assembled monolayers to generate patterned substrates of ECM for cell culture. Meth Mol Biol. 139:209-19. [PDF]

9. Chen, C.S., Ingber, D.E. (1999) Tensegrity mechanoregulation: from skeleton to cytoskeleton. Osteoarth Cart. 7:81-94. [PDF]

8 Chen, C.S., Mrksich, M., Huang, S., Whitesides, G.M., Ingber, D.E. (1998) Using self-assembled monolayers to control cell shape, position, and function. Biotech Prog. 14:356-363. [PDF]

7. Chicurel , M.E., Chen, C.S., Ingber, D.E. (1997) Cellular control lies in the balance of forces [Review]. Curr Op Cell Biol. 10:232-239. [PDF]

6. Roberts, C.S., Chen, C.S., Mrksich, M., Ingber, D.E., Whitesides, G.M. (1998) Using self-assembled monolayers presenting GRGD and EG3OH groups to characterize long-term attachment of bovine capillary endothelial cells to surfaces. J Am Chem Soc. 120:6548-6555. [PDF]

5. Chen, C.S., Mrksich, M., Huang, S., Whitesi