Head Injury Publications
Material Properties
of Brain and Skull Tissue
Pediatric Head Injury
Axonal Injury
Material Properties of Brain and Skull Tissue
Coats BS and Margulies SS. Material Properties of Human Infant Skull and Suture at High Rates. J Neurotrauma 2006: 23(8):1222-1232.
Levchakov A, Linder-Ganz E, Raghupathi R, Margulies SS, and A Gefen Computational Studies of Strain Exposures in Neonate and Mature Rat Brain During Cortical Impact J Neurotrauma 2006:1570-1580.
Ning X., Zhu Q, Lanir Y, and Margulies SS. Development of a Transversely Isotropic, Hyperelastic and Viscoelastic Model for Brainstem undergoing Finite Deformation. J Biomech Eng. 2006 (in press).
Ji S, Dougherty L and Margulies SS. Brainstem Motion within the Skull: Measurement of the Pons Displacement In Vivo J. Biomech 2006 (in press).
Coats BS and Margulies SS. Material Properties of Porcine Parietal Cortex. J Biomech 2006:39: 2521-2525.Ji S, Dougherty
L, Margulies SS. "In vivo measurements of human brain displacement."
Proc of 48th Stapp Car Crash Conference, SAE, 2004.
Gefen A and Margulies SS. "Are in vivo and in situ brain tissues
mechanically similar?" Journal of Biomechanics, 37:1339-1352, 2004.
Gefen A, Gefen N, Zhu Q, Raghupathi R, and Marguiles SS. "Age-Dependent
changes in material properties of the brain and braincase of the rat.
Journal of Neurotrauma, 20:1163-1177, 2003.
Coats B and Margulies SS. "Characterization of pediatric porcine
skull properties during impact." Int Conf of Biomech of Impact,
57-66, 2003.
Prange MT and Margulies SS. "Regional, directional and age-dependent
properties of brain undergoing large deformation." Journal of Biomechanical
Engineering, 124:244-252, 2002.
Margulies
SS and Thibault KL. "Infant skull and suture properties: measurements
and implications for mechanisms of pediatric brain injury." Journal
of Bioimechanical Engineering, 122:364-371, 2000.
Prange MT, Meaney DF, Margulies SS. Defining brain mechanical properties: effects of region, direction, and species. 44th Stapp Car Crash Conference, 2000.
Prange MT, Kiralyfalvi G, Margulies SS. Pediatric Rotational Inertial Brain Injury: The Relative Influence of Brain Size and Material Properties. Proc of 43rd Stapp Car Crash Conf, SAE, 1999 p 333-341.
Arbogast, K.B. and Margulies, S.S. “A fiber-reinforced composite model of the viscoelastic behavior material characterization of the brainstem in shear.” Journal of Biomechanics, 32(8):865-70, 1999 Aug
Margulies
SS and Meaney DF, "Brain Tissues" in Handbook of Biomaterials
Properties, J.
Black and G.
Hastings, eds., Chapman and Hall, New York, 1998.
Thibault, K.L., and Margulies, S.S., “Age Dependent Material Properties of Porcine Cerebrum: Implicatons for Pediatric Head Injury Criteria.” Journal of Biomechanics, 31:1119-1126, 1998. abstract
Arbogast, K.B. and Margulies, S.S. “Material characterization of the brainstem from shear oscillatory tests.” Journal of Biomechanics. 31(9):801-7, 1998 Sep abstract
Arbogast K and Margulies SS. Regional differences in mechanical properties of the central nervous system: Proc of 41st Stapp Car Crash Conf, SAE, 1997 p 293-300. Also published in SAE Tranasactions, 1997, Paper #973336. abstract
Arbogast, K.B., Thibault, K.L., Pinheiro, B.S., Winey, K.I., and Margulies, S. S., "A High-Frequency Shear Device For Testing Soft Biological Tissues," Journal of Biomechanics, Vol 30(7):757-759, 1997. abstract
Thibault KL and Margulis SS. "Material properties of the developing porcine brain." Int. Comm for Biokinetics of Impact. 75-85, 1996.
Pediatric Head Injury
Ichord R., Naim M., Pollack A., Ibrahim N., Christian C, and Margulies SS. Ischemic Injury Complicates Traumatic Brain Injury in Infants. J Neurotrauma (Invited) 2006 (in press).
Margulies SS, Prange M, Myers B, Maltese MR, Ji S, Ning, X, Fisher J, Arbogast K, Christian C. Shaken Baby Syndrome: A Flawed Biomechanical Analysis. Letter to the Editor, Forensic Science International 2006 (in press).
Arbogast KB, Margulies SS and CW Christian Initial Neurological Presentation in Young Children Sustaining Inflicted and Unintentional Fatal Head Injuries. Pediatrics 2005; 116: 180-184.
Prange MT, Coats B, Duhaime AC, Margulies SS. "Anthropomorphic simulations of falls, shakes, and inflicted impacts for infants." Journal of Neurosurgery, 99:143-150, 2003.
Duhaime AC, Margulies SS, Durham SR, O'Rourke MM, Golden JA, Marwaha S, Raghupathi R. Maturation-dependent response of the piglet brain to scaled cortical impact." Journal of Neurosurgery, 93(3):455-462, 2000.
Thibault KL, Kurtz SM, and Margulies SS. Effect of the age-dependent properties of the braincase on the response of the infant brain to impact. International Mechanical Engineers Congress and Exposition, 1997. paper
Duhaime AC, Raghupathi R, Margulies S, Golder J, Humter J, McIntosh T, Marwaha S. "Human and piglet studies on the effect of immaturity on the brain’s response to mechanical trauma. Neurotrauma Society, 1997.
Duhaime, AC. Epplely, M., Margulies, S.S., Heher, K.L. Bartlett, S.P., “Crush injuries to the head in children”, Neurosurgery, 37:401-407, 1995.
Duhaime, AC,
Gennarelli, T.A., Thibault, L.E., Bruce, D.A., Margulies, S.S., Wiser,
R., “The shaken baby syndrome - a clinical, pathological, and biomechianical
study.” Journal of Neurosurgery, 66:409-15, 1987.
Axonal Injury
Friess SH, Ichord R, Owens K, Ralston J, Overall K, Smith C, Helfaer M, and Margulies SS. Neurobehavioral Functional Deficits Following Closed Head Injury in the Neonatal Pig. Exper Neurol 2006: Dec 14.
Prange MT, Zhu Q and Margulies SS. Brain Injury Threshold in Infants. J. Neurotrauma (in review)
Zhu Q, Prange M., Margulies SS. Predicting Unconsciousness From a Pediatric Brain Injury Threshold. Developmental. Neurosci (Invited) 2006:28:388-395.
Zhu Q, Prange
M, Margulies SS. "Development and validation of pediatric axonal
tissue injury threshold." Proc of 48th Stapp Car Crash Conference,
SAE, 2004.
Raghupathi, R, Mehr MF, Helfaer MA, and Margulies SS. Traumatic axonal
injury is exacerbated following repetitive closed head injury in the
neonatal pig. Journal of Neurotrauma, 21:307-316, 2004.
Meaney DF, Margulies SS, Smith DH. "Diffuse axonal injury."
[Letter] Journal of Neurosurgery, 95(6):1108-10, 2001.
Raghupathi, R and Margulies SS. "Traumatic axonal injury following closed head injury in the neonatal pig." Journal of Neurotrauma, 19:843-853, 2002.
Morrison B, Meaney DF, Margulies SS, McIntosh TK. "Dynaimc mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters." Journal of Biomechanical Engineering, 122:224-230, 2000.
Margulies
SS, Meaney DF, Smith D, Chen X-H, Miller R, Raghupathi R. "A comparison
of diffuse brain injury in the newborn and adult pig." Int. Comm
for Biokinetics of Impact, 1999.
Miller RT, Margulies SS, Leoni M, Nonaka M, Chen X, Smith DH, and Meaney
DF. Finite element modeling approaches for predicting experimental
brain injury in an experimental model of severe diffuse axonal head
injury: Proc of 42nd Stapp Car Crash Conf, SAE, 1998.
Margulies, S.S. and Thibault, L.E., “A proposed tolerance criteriaon for diffuse axonal injury in man.” Journal of Biomechanics, 25:7-23, 1992.
Margulies, S.S. and Thibault, L.E., Gennarelli, T.A., “Physical model simulations of brain injury in the primate.” Journal of Biomechanics, 23:832-836, 1990.
Thibault LE, Gennarelli TA, Margulies SS, Marcus JM, Eppinger R. The strain dependent pathophysiological consequences of inertial loading on central nervous system tissue. Proc Int Res Council on Biokinetics of Impact 1990.
Margulies, S.S. and Thibault, L.E., “An analytical model of diffuse brain injury.” Journal of Biomechanial Engineering, 111:241-49, 1989.
Thibault LE, Margulies SS, Gennarelli TA. The temporal and spatial deformation response of a brain model in inertial loading. Proc of 31st Stapp Car Crash Conf, SAE, 1987, p 267-272.
Margulies SS, Thibault LE, Gennarelli TA. A study of scaling and head injury using physical model experiments. Proc Int Res Council on Biokinetics of Impacts, 1985, p 223-234.