Lung Injury Publications
Ventilator-Induced
Lung Injury
Pulmonary Mechanics
Ventilator-Induced Lung Injury
Cohen TS, Cavanaugh KJ and Margulies SS. Alveolar Epithelial Permeability: Effect of Cycling Rate and PEEP AJP-Lung (in review).
Fisher JL and Margulies SS. Modeling the Effect of Stretch and Plasma Membrane Tension on Na+/K+-ATPase in Alveolar Epithelial Cells. Am J Physiol -Cell 2006 (in press)
Levine G, Deutschman C, Helfaer M and Margulies SS. Sepsis Induced Lung Injury in Rats Increases Alveolar Epithelial Vulnerability to Stretch. Crit Care Med 2006:34: 1746-1751.
Cavanaugh
KJ, Cohen TS and Margulies SS. Stretch increases alveolar epithelial
permeability to uncharged micromolecules. Am J Physiol-Cell 2006; 290:C1179-1188.
Patel A, Reigada D, Mitchell CH, Bates SR, Margulies SS. Koval M. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol - Lung Cell Mol 2005: 287:L1266-L1273.
Fisher JL,
Levitan I, and Margulies SS. Plasma membrane surface increases with
tonic stretch of alveolar epithelial cells. Am. J. Resp. Cell Mol Biol
2004:31:200-208.
Cavanaugh KJ and Margulies SS. Measurement of stretch-induced loss of
alveolar epithelial barrier integrity with a novel in vitro method.
Am J Physiol - Cell Physiol, 283:C1801-C1808, 2002.
Fisher JL, Margulies SS. Na(+)-K(+)-ATPase activity in alveolar epithelial cells increases with cyclic stretch. J. Applied Physiology, 283:L737-L746, 2002. abstract
Cavanaugh KJ, Oswari J, Margulies SS. Role of stretch on tight junction structure in alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 25:584-591, 2001, Nov.
Oswari J, Matthay MA, Margulies SS. Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Am J Physiology, 281:L1068-L1077, 2001
Tschumperlin DJ, Oswari J, Margulies SS. Deformation-induced injury of alveolar epithelial cells: effect of frequency, duration, and amplitude. Am J. Resp and Crit Care Med, 152:357-362, 2000.
Tschumperlin, D.J., and Margulies, S.S., “Alveolar Epithelial Surface Area - volume relationship in isolated rat lungs.”, Journal of Applied Physiology 86(6):2026-33, 1999 Jun.
Tschumperlin, D.J., and Margulies, S.S., “Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro.”, American Journal of Physiology - Lung 275(6 Pt 1):L1173-83, 1998 Dec.
Tschumperlin,
D.J., and Margulies, S.S., “Deformation-induced injury of alveolar epithelial
cells: implications for mechanical ventilation.”, American Journal of
Respiratory and Critical Care Medicine (in review)
Brennick MJ, Gefter WB, Margulies SS. Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in cats. Respir Physiol Neurobiol. 2006 Aug 30.
Levinson H, Liu W, Oswari J, Peled Z, Hsu M, Longaker MT, Margulies SS. "Extracellular matrix and seeding density affect cell response to mechanical strain." Journal of Burns. Volume 1, 2002.
Brennick MJ, Ford JC, Margulies SS, Gefter WB, and Pack AI. MRI during stumulus-gatedacquisition shows genioglossal electrical pacing modulates phayrngeal airway size. Am J Resp Crit Care Med, 1998.
Brennick, M.J. Ogivie, M.D., Margulies, S.S., Hiller, L., Gefter, W.B. and Pack, A.I., “MRI study of regional variations of pharyngeal wall compliance in cats.” Journal of Applied Physiology. 85(5):1884-97, 1998 Nov
Boriek, A.M., Rodarte, J.R., Margulies, S.S., “The zone of apposition in the passive diaphragm of the dog.” Journal of Applied Physiology, 81:1929-40, 1996.
Hubmayr, R.D. and Margulies, S.S., “Regional ventilation in statically and dynamically hyperinflated dogs.” Journal of Applied Physiology, 81:1815-21, 1996.
Margulies, S.S., Lei, G.T., Farkas, G.A. Rodarte, J.R., “Finite element anaysis of stress in the canine diaphragm.” Journal of Applied Physiology, 76:2070-75, 1994.
Hubmayr RD, Farkas GA, Tao H-Y, Sieck GC, Margulies SS. Diaphragm mechanics in dogs with unilateral emphysema. J Clin Invest 91:1598-1603, 1993.
Hubmayr RD, Margulies SS. Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure. J Appl Physiol 73(4):1650-1654, 1992.
Margulies SS, Schriner RW, Schroeder MA, Hubmayr RD. Static lung-lung interactions in unilateral emphysema. J Appl Physiol ,73(2):545-551, 1992.
Margulies, S.S., “Regional variation in canine diaphragm thickness.” Journal of Applied Physiology, 70:2663-68, 1991.
Sprung J, Deschamps C, Margulies SS, Hubmayr RD, Rodarte JR. Effect of body position on regional diaphragm function in dogs. J Appl Physiol, 69:2296-2302, 1990.
Margulies SS, Farkas GA, Rodarte JR. Effects of body position and lung volume on in situ length of passive diaphragm. J Appl Physiol, 69:1702-1708, 1990.
Liu S, Margulies SS, Wilson TA. Deformation of the dog lung in the chest wall. J Appl Physiol, 68:1979-1987, 1990.
Margulies SS, Rodarte JR, Hoffman EA. Shape of the chest wall in the prone and supine anesthetized dog. J Appl Physiol, 68:1970-1978, 1990.
Margulies SS, Rodarte JR, Hoffman EA. Geometry and kinematics of dog ribs. J Appl Physiol, 67:707-712, 1989.