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Injury Biomechanics
Cells within the body routinely tolerate deformations during activities such as head turning and breathing. In contrast, cell structure and function are altered when cells are deformed beyond safe limits.Injury Biomechanics is the study of how cells and tissues respond when exposed to mechanical forces, with a focus on the complex relationships between early and long term changes in structure and function. With this knowledge, new intervention strategies are being developed to improve cell and tissue recovery from injury. In addition, the investigators measure tissue mechanical properties and injury thresholds, and develop computational models to generalize the cell and tissue results to a macroscopic level and determine injury mechanisms.These studies parallel clinical investigations regarding the treatment and detection of traumatic injury. Applications of current work are in the areas of traumatic brain and spine injury in adults and children, and ventilator-induced lung injury.
Dr. Kristy Arbogast
Dr. Beth Winkelstein
Bioengineering
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Department of Bioengineering
School of Engineering and Applied Science
University of Pennsylvania
210 S. 33rd Street
Room 240 Skirkanich Hall
Philadelphia, PA 19104
Phone No.: (215) 898-8501
Fax No.: (215) 573-2071
beoffice@seas.upenn.edu
Send Comments and Suggestions to:
beweb@seas.upenn.edu
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