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Three-dimensional treatment planning; optimization, and decision analysis for radiation therapy, and surface mensuration by laser beams.
Research Assistant Professor, Pediatrics
Associate Director, Field Engineering, Center for Injury Research
and Prevention
Children's Hospital of Philadelphia
Pediatric biomechanics towards the development of improved child anthropomorphic dummies and the enhancement of the mechanistic understanding of unintentional injuries.
Director, Center for Human Modeling and Simulation Computer graphics, human movement simulation and animation, kinematics and dynamics, three-dimensional object representations, interactive software and systems design, facial expression synthesis, artificial intelligence, process simulation and reasoning, representation of functionality, semantics of motion verbs, dynamic visual scene analysis, integrated graphics and language system.
String theory - origin of cosmological constant; cosmology and physics of singularities; black hole thermodynamics; information transmission in biological systems.
Novel surgical strategies for the treatment of epilepsy and degenerative diseases. The biology of glia in disease.
Nuclear magnetic resonance characterization of tumors, treatment planning of radiation therapy, and tumor localization using MRI x-ray fluorescence to determine heavy metals in situ.
Mechanical and electrical interface properties; local electronic structure of oxides at chemical and structural defects; electronic structure variation occurring during brittle fracture.
Human vision, machine vision and computational modeling of visual processing.
Investigation of candidate therapeutic
transgenes for heart failure and
Research Associate Professor of Ophthalmology Electrophysiology of phototransduction and postreceptoral function; understanding of functional deficits in hereditary retinal degenerations caused by known gene mutations; imaging of the retina at high resolution or low light level.
Perception of spatial layout, perceptual calibration, and binocular vision.
Intracellular recordings with sharp electrodes and optical recordings with voltage sensitive dyes in vivo and in vitro. Information encoding in the visual system.
Epilepsy, neuronal excitability, CNS rhythm generation, GABA receptors, development of neurotransmitter receptors and ion channels, synaptic function
Skirkanich Assistant Professor of Innovation in Chemical Engineering Cellular and molecular biophysics; soft matter engineering.
Associate Professor of Radiology Deformable models, brain mapping, nonlinear image registration, image-guided surgery.
Co-Director - Center for Bioinformatics Research and education in the rapidly emerging fields of bioinformatics and computational biology, disciplines which deal with the analysis and management of data generated by high-throughput techniques in genomics, molecular and cellular biology. The ultimate goal of our collaborative research is to integrate all levels of information, including the genome sequence, the state of the cell (e.g., transcriptome and the proteome) and the phenotype.
Macromolecule structure and function, de novo design of proteins, design of small molecules that inhibit cell interactions, membrane-active peptides.
Molecular basis of neuronal functioning; molecular and bioprocess fingerprints of various cell types and disease states.
Member of The Institute for Medicine and Engineering Pulmonary and cardiovascular biofluid mechanics and biotransport phenomena.
Biologically inspired polarization-difference imaging, fractional calculus in electrodynamics, wave interaction with complex media.
Several Complex Variables, Deformations of Singularities, Microlocal Analysis and Index Theory, Image Reconstruction.
Aspects of computational anatomy and biomedical computing. Topics include: Image registration and segmentation; Pattern analysis; Morphometry; Diffusion tensor image processing; Imaging studies of brain structure and function.
Study of electrical activity of as many single neurons as possible in order to examine how functional assemblies form and change during behavior of the whole organism. Use of computer neuronal network simulations to aid in interpreting data from real neurons. Such measurements are made in both sensory and motor systems of several types of organisms.
Design of an in vitro chronic wound model;
fibroblast populated collagen matrix, applying known electronic
fields similar to postulated endogenous fields in wounds, and obtaining
metabolic responses. Clinical projects include: 1) a blinded clinical
study of influence of pulsed electromagnetic fields on healing
chronic diabetic foot ulcers;
Professor of Physiology Member of The Institute for Medicine and Engineering Molecular mechanism of muscle contraction
and protein synthesis relating structural, mechanical and biochemical
events in the contractile
Cell signalling; explore design principles underlying circuits used by cells to tranduce, interpret, and respond to their enviroment.
Memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery
Cerebral blood flow and metabolism in various physiological conditions: stroke, ischemia, functional activation, systemic hypertension; and Positron Emission Tomography.
Assistant Professor of Cell Biology Regulation of mesenchymal stem cell quiescence, proliferation, and fate; osteoblast-adipocyte reciprocal differentiation; bone formation and regeneration; cell-extracellular matrix interactions
Physics and technology of Medical Imaging, especially Nuclear Magnetic Resonance imaging; techniques for selective imaging of chemical shift and blood flow; physiologic imaging of fluorinated blood substitutes; and imaging of natural endogenous sodium.
Member of The Institute for Medicine and Engineering The molecular genetics of disorders of ossification; and the topographic organization of repetitive elements in the human genome.
Condensed Matter Physics; algorithms that mimic biological brains; human-machine interactions.
Chief of Functional MR Research Development and application of magnetic resonance techniques; optical imaging in highly scattering media, such as the human body; theoretical and experimental studies of protein folding and structure.
Regulation of endothelial ion channels gating by mechanical forces: The interaction between cytoskeletal proteins and mechanosensory ion channels. The roles of cytoskeletal proteins in gating of these channels are studied using a combination of electrophysiological and visual imaging techniques.
Interaction of biochemical concepts, pharmacology, pharmaceutics and biomaterials. Current projects in the laboratory are concerned with mechanisms of cardiac valve and blood vessel calcification, localized gene therapy for wound healing, myocardial implants for cardiac arrhythmia and primary syntheses of therapeutic polymers for biomaterial use.
Computer technology for medical imaging, in particular, the formulation and computer implementation of algorithms for image reconstruction from projection data, as derived from transmitted x-rays or emitted gamma rays.
Microcirculation, peripheral circulatory control, tissue oxygenation, and endothelial-vascular smooth muscle cell-cell interactions.
Associate Professor of Medicine Director, Heart Failure and Transplant Research
Director, Cardiac Myocyte Core Lab
Myocardial remodeling and reverse remodeling, Heart failure with preserved ejection fraction, E-C coupling and regulation of contractility, Endogenous cardiac repair, Natriuretic peptide biology
Associate Scholar in the Center for Clinical Epidemiology and Biostatistics Professor Merz holds degrees in nuclear engineering, business, law, and the PhD in Engineering and Public Policy, and he is a registered patent attorney. His research interests encompass privacy and confidentiality in medicine and research, reproductive rights and policy, research ethics and regulation, conflicts of interest, informed consent, and issues raised in the foregoing areas by biotechnology.
Drug/gene targeting and vascular biology.
Director of the Center for Sleep and Respiratory Neurobiology Neural control of respiration during sleep, spectral analysis, pattern generators, non-linear dynamical analysis, and computational neuroscience.
Tumor biology; signal transduction; leukemogenesis, including chronic myelogenous leukemia and myeloproliferative diseases; hematopoietic stem cell, biology.
Intracellular signaling and genomic response
in traumatic brain injury, focusing on cell death/survival pathways.
Development of sodium and proton MRI based diagnostic tools for detecting early degenerative changes in cartilage.
Human Auditory Perception, Psycophysics, and Mathematical Psychology.
Cell biology and molecular genetics of protozoan parasites: Toxoplasma and Plasmodium (malaria); eukaryotic evolution; computational biology.
Professor of Neuroscience The structure and function of the peripheral auditory system, the micro and macromechanics of the middle ear, (tympanic membrane) and inner ear (hair cells); cellular activity in the peripheral auditory nervous systems; mechanism of hair cell transduction; signal processing in the cochlea; middle ear transmission.
Lipid transport, actomyocin interaction, molecular mechanism of anesthesia.
Associate Professor of Neurosurgery Modeling focal and diffuse brain injury, post-traumatic cognitive dysfunction, and traumatic axonal injury; techniques for diagnosis and treatment of brain trauma.
Assistant Professor, Department of Radiology Novel MR Imaging techniques; alternate MR data sampling strategies;
motion
compensation; dynamic MRI; in vivo iron quantification using
MRI.
Genomics unified schema used to itegrate sequence and its annotation from several sources and structure in a database; understand gene regulation and build models for genetic networks.
Generation of positional information within cells by the cytoskeleton
Visualization and analysis of multi-dimensional biomedical images; computer graphics for medical applications; kinematics of joints from image sequences; and volume rendering.
Member, Institute for Medicine and Engineering Our laboratory studies the relationship between tissue architecture and the plasticity of gene expression. The present objective of our work is to delineate the molecular mechanisms driving malignant transformation of benign breast lesions, and to understand the pathophysiology of multi-drug resistant, metastatic breast cancer.
Quantitative medical magnetic resonance imaging.
Arjun Yodh, Ph.D.
Fundamental and applied condensed matter physics, biomedical optics & biophysics, and optical science. Current research includes: soft materials, complex fluids & networks, carbon nanotubes, optical microscopy & micromanipulation, biomedical optics, functional imaging & spectroscopy of living tissues, photodynamic therapy and nonlinear optics.
Radiology /Molecular Imaging Laboratory Develop and implement molecular imaging approaches to study cancer and cardiovascular diseases. Specific projects include stem cell based cardiac regeneration, cardiac kinematics using magnetic resonance (MR) imaging based techniques, and study of tumor microenvironment by MR imaging and spectroscopy.
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