David
F. Meaney, Ph.D.
dmeaney@seas.upenn.edu
Professor of Bioengineering; Member
of the Institute for Medicine and Engineering, and Bioengineering
Graduate Group Chair
B.S., Biomedical Engineering,
Rensselaer Polytechnic Institute, 1987
M.S.E., Bioengineering,
University of Pennsylvania, 1988
Ph.D., Bioengineering,
University of Pennsylvania, 1991
Research Interests
The process of mechanotransduction
is critical in understanding the response of cells and tissues of
the central nervous system (CNS) to traumatic injury. In this research
area, experimental work is combined with mathematical modeling to
provide a method to quantify the effect of physical forces on cell
and tissue function. For example, some of the research combines
finite element models of the brain with experimental work to estimate
the tissue mechanical stress/strain associated with biological markers
of injury. These models provide a starting point to relate traditional
measures of stress to the microstructural constituents of the tissue.
Structural models are being developed to link global mechanical
deformations and the resulting deformation of cellular/subcellular
microstructures in the CNS white matter. With the kinematic transformations
between the macroscopic deformations and cellular components of
the CNS
white matter now better
established, the research has expanded to determine the mechanism(s)
by which a mechanical signal is converted into a biochemical signaling
cascade for organotypic tissue, cultured neurons, and cultured axons.
Selected Publications
A device to injure in
vitro central nervous system tissue. Annals of Biomedical Engineering.
v.26, 381-390, 1998.
In vitro central nervous
system models of mechanically induced trauma: A review. Journal
of Neurotrauma. v. 15 no. 11, 1998.
Experimental investigation
of cerebral contusion: histopathological and immunohistochemical
evaluation of dynamic cortical deformation. Journal of Neuropathology
and Experimental Neurology.58(2):153-164, 1999 Feb.
High tolerance and delayed
elastic response of cultured axons to dynamic stretch injury. Journal
of Neuroscience, 19(11):4263-4269, 1999.
Bioengineering
| Penn Engineering Home
| Penn Home |
City of Philadelphia
Faculty
& Staff |
Graduate Program |
Undergraduate Program |
Research
| Labs & Organizations
| Events
Course
Listings
|
BE Links
| Site Index |
Admission
| Employment
|
