Leif
Finkel, M.D., Ph.D.
leif@neuroengineering.upenn.edu
Professor of Bioengineering;
Member of the Institute for Neurological Sciences; Member of the
Institute for Medicine and Engineering; Member of the Institute
for Research in Cognitive Science
B.S., Physics, University
of Maryland, 1976
M.D., University of Pennsylvania, 1981
Ph.D., Biophysics, University of Pennsylvania, 1985
Research Interests
Our
lab is devoted to trying to understand computation in real neural
circuits, and to applications of these insights to neurological
and psychiatric diagnosis and treatment. We are developing biophysical
level simulations of neocortex, hippocampus and basal ganglia. Current
applications are directed at understanding the alterations in brain
function in schizophrenia, seizure disorders, and Parkinson's disease.
An underlying theme is the study of mechanisms of neural oscillations,
synchronization, and integration of multiple inputs to a cell. We
have close collaborations with colleagues working on electrophysiology,
human intracranial EEG and deep brain recording, fMRI, and implanted
seizure detection/termination devices.
A
second focus of the lab is on visual perception. We are particularly
interested in neural mechanisms of spatiotemporal pattern recognition
and Bayesian integration with a current focus on biological motion
perception.
Selected Publications
Edelman,
G.M. and Finkel, L.H., "Neuronal Group Selection in the Cerebral
Cortex ," Dynamic Aspects of Neocortical Function,
G.M. Edelman, W.E. Gall, and W.M. Cowan, eds., pp. 653-695, John
Wiley, New York, 1984.
Finkel,
L.H. "Constructing Visual Perception," American Scientist,
82: 224-237, 1994.
Sajda,
P. and Finkel, L.H. Intermediate-Level Visual Representations and
the Construction of Surface Perception, Journal of Cognitive
Neuroscience 7:267-291, 1995.
Sakai
, K. and Finkel, L.H. Characterization
of Spatial Frequency Cues in the Perception of Shape-from-Texture,
Journal of the Optical Society of America A 12: 1208-1224,
1995.
Yen,
S.C. and Finkel, L.H. "Extraction of Perceptually Salient Contours
by Striate Cortical Networks", Vision Research ,
38, 719-741, 1998.
Menschik
ED, Finkel LH (1999) Cholinergic neuromodulation and Alzheimer's
disease: from single cells to network simulations. Progress in Brain
Research, 121:19-45.
Finkel,
L.H. (2000) Neuroengineering Models of Brain Disease", Annual
Reviews of Biomedical Engineering, 2: 577-606.
Finkel,
L.H. (2002) Neural Computation: Neocortex. In. Encyclopedia of Learning
and Memory, 2 nd ed., L. Squire, et al., eds. Academic Press.
M.T.
Lazarewicz, S. Das, and L.H. Finkel. (2005) Recognition of temporal
event sequences by a network of cortical neurons. Neurocomputing
65-66: 143-151.
Wolf,
J.A., Moyer, J.T., Lazarewicz, M., Contreras, D., Benoit-Marand,
M., O'Donnell, P., and Finkel, L.H. (2005) NMDA: AMPA Ratio Impacts
State Transitions and Entrainment to Oscillations in a Computational
Model of the Nucleus Accumbens Medium Spiny Projection Neuron. J.
Neuroscience (in press).
Bioengineering
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