Paul Ducheyne, Ph.D.
ducheyne@seas.upenn.edu
Center
for Bioactive Materials and Tissue Engineering
Professor of Bioengineering;
Professor of Orthopaedic Surgery Research; Member of the Institute
for Medicine and Engineering; Director of Center for Bioactive Materials
and Tissue Engineering
M.Sc., Materials Science
and Engineering, 1972, Katholieke Universiteit Leuven, Belgium
Ph.D., Materials Science, 1976, Katholieke Universiteit Leuven,
Belgium
Research Interests
Since the late 1980's
when the challenge of in vitro synthesis of bone tissue was first
addressed, the investigation of mechanistic effects of materials
on cellular functions, specifically cell attachment, proliferation,
differentiation and extracellular matrix formation, have been central
to this labs activities. Analyses deal extensively with the interface
zone between materials and cells and tissues, using both materials
science techniques as well as life science methods. In addition,
studies focus on the combined effects of microgravity and substrate
material on cellular functions; and on material surface modification
and controlled release of growth factors. Several tissue engineering
applications are pursued. Specifically, the laboratory studies whether
bone defects can be repaired with full return of mechanical function
by treating defects with in vitro synthesized bone tissue. Another
project involves the treatment of intervertebral disk degeneration
with tissue engineered constructs.
Selected Publications
Bioactive Ceramics, Editorial,
J. Bone Jnt. Surg., 76B, 861-862, 1994.
Si-Ca-P xerogels and bone
morphogenetic protein act synergistically on rat stromal marrow
cell differentiation in vitro. J Biomed. Mater. Res., 41, 87-94,
1998.
The effect of surface
reaction stage on fibronectin-mediated adhesion of osteoblast-like
cells to bioactive glass. J Biomed Mater Res. Apr;40(1):48-56, 1998.
Stimulation of biological
function with bioactive glass. MRS Bulletin, 43-49, November 1998.
In vitro behavior of silica-based
xerogels intended as controlled release carriers. J. Am. Ceram.
Soc., 82, 969-976, 1999.
Bioengineering
| Penn Engineering Home
| Penn Home |
City of Philadelphia
Faculty
& Staff |
Graduate Program |
Undergraduate Program |
Research
| Labs & Organizations
| Events
Course
Listings
|
BE Links
| Site Index |
Admission
| Employment
|
