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Susan Margulies, Ph.D.
Professor of Bioengineering; Member of the Institute for Medicine and Engineering B.S.E., Mechanical and
Aerospace Engineering, Princeton University, 1982 Research Interests Cells within the body routinely tolerate deformations during activities such as head turning and breathing, yet when cells are deformed beyond a safe limit or injury threshold, function and structure are altered temporarily or even permanently. Our goal is to determine functional and structural injury thresholds in the brain and lung, and use them to understand mechanisms of traumatic brain and lung injury. In addition, our study of the biochemical and molecular biology of injured cells facilitates the development of preventive and therapeutic measures. Because human tissues tend to be inhomogeneous, anisotropic and nonlinear, and the tissues of interest undergo large strains, determining the complex relationship between cellular and macroscopic responses requires an integrated biomechanics approach consisting of several simultaneous rigorous engineering experimental and theoretical analyses. Tissue mechanical properties and injury thresholds are measured and used to develop computational models. These models are used to generalize our experimental cell and tissue findings and determine macroscopic injury mechanisms. Applications of current work are in the areas of traumatic head injury in adults and children, and ventilator-induced lung injury. These studies parallel clinical investigations regarding the treatment and detection of traumatic injury. Selected Publications Fisher J and Marguilies SS. Na+-K-ATPase activity in alveolar epithelial cells increases with cyclic stretch. J. Appl Physiol. 2002; 283: L737-L746. Prange MT and Margulies SS. Regional, directional and age-dependent properties of brain undergoing large deformation. J Biomed Eng. 2002; 124:244-252. Raghupathi R and Margulies SS. Traumatic axonal injury after closed head injury in the neonatal pig. J Neurotrauma 2002; 19:843-853. Cavanaugh KJ and Margulies SS. Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method. Am J Physiol Cell 2002; 283:1801-C1808. Prange MT, Coats B, Duhaime AC and Margulies SS. Anthropomorphic simulations of falls, shakes and inflicted impacts for infants. J Neurosurg. 2003; 99: 143-150.
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