Louis
J. Soslowsky, Ph.D.
soslowsk@mail.med.upenn.edu
Professor of Orthopaedic
Surgery and Associate Professor of Bioengineering; Director of Orthopaedic
Research; Member of the Institute for Medicine and Engineering
Ph.D., Engineering Mechanics
Columbia University, 1991
M.Phil., Columbia University,1989
M.S., Engineering Mechanics Columbia University, 1987
Research Interests
My research program covers a broad area related to orthopaedic biomechanics
and tissue engineering particularly related to soft connective tissues
and mechanics of joints through a series of multidisciplinary studies.
One main research area focuses on understanding the etiologic factors
and pathologic mechanisms associated with tendon and ligament injury,
healing, repair, and regeneration. In addition, fundamental structure-function
relationships for tendon and ligament are quantitatively evaluated.
A
variety of experimental animal models, including transgenic and
knockout mice, rats, and large animals are used to test various
hypotheses. Mathematical models are also utilized to further investigate
these
mechanisms and relationships. An additional focus area is related
to shoulder and elbow joint mechanics. These studies focus on relationships
between tissue strain fields and joint loading and arm positions
in both normal and abnormal states. Investigations concerning the
role of the joint capsule and related musculature are also included.
Selected Publications
Gimbel, J.A., Van Kleunen,
J.P., Mehta, S., Perry, S.M., Williams, G.R., and Soslowsky, L.J.:
Supraspinatus tendon structural and mechanical properties in a chronic
rotator cuff tear animal model. J Biomechanics, 37 :739-749,
2004
Lin, T.W., Cardenas, L, and Soslowsky, L.J.: Biomechanics of tendon
injury and repair. J Biomechanics, 37 :865-877, 2004
Robinson, P.S., Lin, T.W., Reynolds, P., Derwin, K., Iozzo, R.,
and Soslowsky, L.J.: Strain rate sensitive mechanical properties
of tendon fascicles from mice with genetically engineered alterations
in collagen and decorin. J Biomech Eng, 126 :252-257,
2004
Robinson, P.S., Lin, T.W., Reynolds, P., Jawad, A., Iozzo, R., and
Soslowsky, L.J.: Investigating tendon fascicle structure-function
relationships in a transgenic-age mouse model using multiple regression
models. Annals Biomed Eng, 32 :924-931, 2004
Gimbel, J.A., Mehta, S., Van Kleunen, J.P., Williams, G. R., and
Soslowsky, L.J.: The tension required at repair to re-appose the
supraspinatus tendon to bone rapidly increases following injury.
Clin Orth Rel Res, 426 :258-265, 2004
Lin, T.W., Cardenas, L, and Soslowsky, L.J.: Tendon properties in
interleukin-4 and interleukin-6 knockout mice. J Biomechanics, 38
:99-105, 2005
Bioengineering
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