Ravi Radhakrishnan, Ph.D.

rradhak@seas.upenn.edu

Assistant Professor of Bioengineering

B. Tech, 1995, Indian Institute of Technology, Madras
Ph.D., 2001, Cornell University

Research Interests

With the objective of designing drugs rationally and customized to specfic patients, we investigate biochemical phenomena at various length and timescales from electronic structure to signaling pathways by employing tools from computational biology, statistical mechanics, quantum mechanics, and high performance computing. My research interests lie in the interface of chemical physics and molecular biology and is currently focussed on biophysical and biochemical aspects of carcinogenesis, therapeutic inhibition of signaling enzymes, RNA catalysis, membrane phenomena, and resistance mechanisms in antibiotics.

Selected Publications

R. Radhakrishnan and T. Schlick, "Biomolecular Free Energy Profiles by a Shooting/Umbrella Sampling Protocol (BOLAS)", 2004, J. Chem. Phys., 121, 2436.

R. Radhakrishnan and T. Schlick, "Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta’s closing", 2004, Proc. Nat. Acad. Sci., 101, 5970.

R. Radhakrishnan, B. L. Trout, "Nucleation of crystalline phases of water under homogeneous and inhomogeneous environments", 2003, Phys. Rev. Lett., 90, 158301

C. Lo, C. A. Giurumescu, R. Radhakrishnan, B. L. Trout, "Methanol coupling in the zeolite chabazite studied via first-principles molecular dynamics", 2004 Mol. Phys., 102, 281.

Department of Bioengineering
School of Engineering and Applied Science
University of Pennsylvania
210 S. 33rd Street
Room 240 Skirkanich Hall
Philadelphia, PA 19104
Phone No.: (215) 898-8501
Fax No.: (215) 573-2071
beoffice@seas.upenn.edu

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