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Bioengineering Graduate
Group Faculty Members
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| Kristy Arbogast , Ph.D. |
Pediatric biomechanics towards the development of improved child anthropomorphic dummies and the enhancement of the mechanistic understanding of unintentional injuries.
| Norman Badler, Ph.D. |
Director, Center for Human Modeling and Simulation
Computer graphics, human movement simulation and animation, kinematics and dynamics, three-dimensional object representations, interactive software and systems design, facial expression synthesis, artificial intelligence, process simulation and reasoning, representation of functionality, semantics of motion verbs, dynamic visual scene analysis, integrated graphics and language system.
| Vijay Balasubramanian, Ph.D. |
String theory - origin of cosmological constant; cosmology and physics of singularities; black hole thermodynamics; information transmission in biological systems.
| Gordon Baltuch,M.D., Ph.D. |
Associate Professor of Neurosurgery
Director, Center for Functional and Restorative Neurosurgery
Novel surgical strategies for the treatment of epilepsy and degenerative diseases. The biology of glia in disease.
| Peter Bloch, Ph.D. |
Nuclear magnetic resonance characterization of tumors, treatment planning of radiation therapy, and tumor localization using MRI x-ray fluorescence to determine heavy metals in situ.
| Dan Bogen, Ph.D. |
Associate Professor of Bioengineering
Associate Professor of Bioengineering in Medicine
Associate Professor of Rehabilitation Medicine
Associate Professor of Bioengineering in Pediatrics
107 Hayden Hall
(215) 573-2726
Cognitive rehabilitation; rehabilitation product design; toys for disabled children; customized manufacturing, and adaptive technology for cognitive and physical impairments.
| Dawn Bonnell, Ph.D. |
Materials Science & Engineering
Mechanical and electrical interface properties; local electronic structure of oxides at chemical and structural defects; electronic structure variation occurring during brittle fracture.
| David Brainard, Ph.D. |
Human vision, machine vision and computational modeling of visual processing.
| Charles R. Bridges, M.D., Sc.D. |
Associate Professor Surgery,
Division of Cardiothoracic Surgery
Investigation of candidate therapeutic
transgenes for heart failure and
coronary artery disease; novel strategies for adeno-associated
virus-mediated transgene delivery including cardiopulmonary bypass
with in-situ cardiac isolation; experimental models of heart failure,
including isolated-perfused rodent heart models with microsurgical heterotopic
heart transplantation; cardiac mechanics: experimental assessment
of cardiac function and theoretical models of ventricular mechanics.
| Gershon Buchsbaum, Ph.D. |
Professor of Bioengineering
Deputy Chair, Bioengineering
Member, Institutes for Neurological Sciences
Member, Institute for Medicine and Engineering
Member, Institute for Research in Cognitive Science
240 Skirkanich Hall 107 Hayden Hall |
(215) 573-2726 |
Human visual perception in simple and spatially complex visual fields; visual signal processing and image coding. Modeling of retinal visual system architecture and function.
| Donald G. Buerk, Ph.D. |
| Physiology - A207 Richards | (215) 898-9097 |
Oxygen metabolism, neurological function and autoregulation of blood flow in the eye, carotid body, brain, vascular wall and other tissues. Mechanisms of chemo-transduction and hypoxic vasodilation. Oxygen toxicity, recovery from hypoxia and reperfusion injury. Development of new electrochemical detection techniques. Mathematical modeling of biotransport phenomena.
| Jason Burdick, Ph.D. |
Wilf Family Term Assistant Professor of Bioengineering
| 102 Hayden Hall | 215-898-8537 |
Polymeric Biomaterials Laboratory, Photopolymerization, Drug Delivery, Cartilage and Bone Tissue Engineering, Spinal Cord Injury
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| Christopher S. Chen |
Skirkanich Associate Professor of Innovation in Bioengineering
| 510 Skirkanich Hall | (215) 746-1754 |
Micro- and Nanotechnology; Transduction of mechanical forces by cells; Relationship between cellular and multicellular structure and biological function; Angiogenesis; Cancer; and Stem cell biology. Dr. Chen's laboratory studies how the interactions between cells and their surrounding tissue microenvironment drives their behavior. His group develops novel microfabriaction and nanotechnology-based tools to manipulate and monitor these interactions in order to better understand how cells function in normal and disease contexts.
| Artur Cideciyan, Ph.D. |
Research Associate Professor of Ophthalmology
Electrophysiology of phototransduction and postreceptoral function; understanding of functional deficits in hereditary retinal degenerations caused by known gene mutations; imaging of the retina at high resolution or low light level.
| Akiva Cohen, Ph.D. |
Assistant Professor of Pediatrics
Department of Neurology
Perception of spatial layout, perceptual calibration, and binocular vision.
| Russell J. Composto, Ph.D. |
| 401 LRSM | (215) 898-4451 |
Polymer surfaces and interfaces , wetting, adhesion, adsorption, polymer precursors to ceramics, ion scattering.
| Diego Contreras, M.D., Ph.D. | More Info |
Associate Professor, Dept of Neuroscience
School of Medicine
Intracellular recordings with sharp electrodes and optical recordings with voltage sensitive dyes in vivo and in vitro. Information encoding in the visual system.
| Douglas Coulter, Ph.D. |
Epilepsy, neuronal excitability, CNS rhythm generation, GABA receptors, development of neurotransmitter receptors and ion channels, synaptic function
| John Crocker, Ph.D. |
Skirkanich Assistant Professor of Innovation in Chemical Engineering
Chemical and Biomolecular Engineering
Institute for Medicine and Engineering
Pennsylvania Muscle Institute
Cell mechanics and rheology, self-assembly by molecular recognition, soft glasses, single-molecule science, colloidal interactions, optical trapping
| Christos Davatzikos, Ph.D. |
Director, Section of Biomedical Image Analysis
Professor, Department of Radiology
Image processing and analysis, Deformable models and registration, computational anatomy, Neuroimaging of Alzheimer's Disease and schizophrenia, Modeling and analysis methods for surgical planning and guidance, Genotype/Phenotype relationships examined via imaging methods.
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Professor of CIS Research and education in the rapidly emerging fields of bioinformatics and computational biology, disciplines which deal with the analysis and management of data generated by high-throughput techniques in genomics, molecular and cellular biology. The ultimate goal of our collaborative research is to integrate all levels of information, including the genome sequence, the state of the cell (e.g., transcriptome and the proteome) and the phenotype. |
| Peter F. Davies, Ph.D. |
Professor of Pathology and Laboratory Medicine
Professor of Bioengineering
| IME - 1010 Vagelos Labs | (215) 898-4647 |
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics and computational fluid dynamics.
| William F. DeGrado, Ph.D. |
Macromolecule structure and function, de novo design of proteins, design of small molecules that inhibit cell interactions, membrane-active peptides.
| Jim Delikatny, Ph.D. |
Research Associate Professor of Radiology
MR spectroscopy, MR imaging, anticancer drugs, lipid metabolism, cancer pharmacology
| Scott Diamond, Ph.D. |
Arthur E. Humphrey Professor of Chemical Engineering Professor of Bioengineering Director, Penn Center for Molecular Discovery Associate Director, Institute for Medicine and Engineering |
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| IME - 1010 Vagelos Labs | (215) 898-8652 |
Endothelial cell mechano-biology, drug and gene delivery, thrombosis and thrombolysis, biotransport phenomena.
| Professor of Chemical and Biomolecular Engineering Professor of Bioengineering Professor of Mechanical Engineering and Applied Mechanics Member: Institute for Medicine and Engineering |
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| 129 Towne | (215) 898-4809 |
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Membrane & Cytoskeleton thermodynamics, mechanics, self-assembly, and adhesion/cohesion in disease and differentiation, including the strong influence of microenvironment mechanics on tissue cell differentiation. Self-assembling polymer macro-surfactants as synthetic viruses for drug delivery (eg. "Polymersomes") and as 'better materials for better biology". Cell systems of particular interest include myocytes, stem cells, and blood cells. Single molecule biophysics and mechanochemistry, especially Atomic Force Microscopy nano-methods. Statistical mechanics of self-assembly, self-organization, networks, proteins, and polymers, with computational emphasis.
| Paul Ducheyne, Ph.D. |
Professor of Bioengineering
Professor of Orthopaedic Surgery Research
Director of Center for Bioactive Materials and Tissue Engineering
Member, Institute for Medicine and Engineering
| 115 Hayden Hall | (215) 898-1521 |
Biomaterials and Tissue Engineering. In vitro synthesis of musculoskeletal tissues. Bioactive ceramics, including hydroxyapatite, bioactive glass and bioactive composites. Porous metals: surface analysis, biocompatibility and electrochemical properties. Materials engineering, mechanical properties, design and stress analysis. Orthopaedic and dental applications. Implant retrieval and analysis.
| James Eberwine, Ph.D. |
Molecular basis of neuronal functioning; molecular and bioprocess fingerprints of various cell types and disease states.
| David M. Eckmann, Ph.D., M.D. |
Member of The Institute for Medicine and Engineering
Pulmonary and cardiovascular biofluid mechanics and biotransport phenomena.
| Wafik S. El-Deiry, M.D., Ph.D. |
Associate Professor of Medicine
Associate Professor of Genetics
Associate Professor of Pharmacology
Assistant Investigator, Howard Hughes Medical Institute
Director, Laboratory of Molecular Oncology and Cell Cycle Regulation
The EL-DEIRY LAB is a Molecular Oncology Laboratory dedicated to the identification and characterization of cell cycle and cell death abnormalities in chemo- and radioresistant cancers.
215-898-9072 |
| Dawn M. Elliott, Ph.D. |
Associate Professor of Bioengineering
Member, Institute for Medicine and Engineering
| 424 Stemmler | (215) 898-5583 |
Biomechanics of collagenous soft tissues, intervertebral disc, tendon and ligament, meniscus and articular cartilage biomechanics in health, aging, degeneration, and injury.
| Nader Engheta, Ph.D. |
Biologically inspired polarization-difference imaging, fractional calculus in electrodynamics, wave interaction with complex media.
| Charles Epstein, Ph.D. | More Info |
Several Complex Variables, Deformations of Singularities, Microlocal Analysis and Index Theory, Image Reconstruction.
| Leif H. Finkel, M.D., Ph.D. |
Professor of Bioengineering
Member, Institutes for Neurological Sciences
Member, Institute for Medicine and Engineering
Member, Institute for Research in Cognitive Science
| 301 Hayden Hall | (215) 898-0822 |
Neuroengineering and Computational Neuroscience. Computational mdoeling of cortex, hippocampus and basal ganglia directed at understanding mechanisms of neurologic and psychiatric disease. Computational studies of visual recognition and cortical integration.
| Kenneth R. Foster, Ph.D., P.E. |
Professor of Electrical Engineering
| 106 Hayden Hall | (215) 898-8534 |
Biomedical applications of nonionizing radiation from audio through microwave frequency ranges, including hyperthermia and clinical impedance techniques, dielectric properties of tissues, biological molecules, suspensions, transport properties of complex suspensions, environmental issues related to nonionizing radiation.
| James C. Gee, Ph.D. |
Aspects of computational anatomy and biomedical computing. Topics include: Image registration and segmentation; Pattern analysis; Morphometry; Diffusion tensor image processing; Imaging studies of brain structure and function.
| Yale E. Goldman, M.D., Ph.D. |
Professor of Physiology
Member of The Institute for Medicine and Engineering
Molecular mechanism of muscle contraction
and protein synthesis relating structural, mechanical and biochemical
events in the contractile
proteins and ribosomal elongation factors.
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Cardiac Surgery Attending Surgeon Hospital of University of Pennsylvania |
Associate Professor of Surgery
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| Mark Goulian, Ph.D. |
Associate Professor of Biology and of Physics and Astronomy
Member, Institute for Medicine and Engineering,
Cell signalling; explore design principles underlying circuits used by cells to tranduce, interpret, and respond to their enviroment.
| M. Sean Grady, M.D. |
Memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery
| Joel H. Greenberg, Ph.D. |
Cerebral blood flow and metabolism in various physiological conditions: stroke, ischemia, functional activation, systemic hypertension; and Positron Emission Tomography.
| Daniel A. Hammer, Ph.D. |
Ennis Professor of Bioengineering
Professor of Chemical Engineering
Member: Institute for Medicine and Engineering
| 535 Skirkanich Hall | (215) 573-6761 |
Cellular bioengineering, cell adhesion, virus - cell interactions, membrane dynamics and structure, novel biomaterials and biomimetics.
| Kurt Hankensen. D.V.M., M.S., Ph.D. |
Assistant Professor of Cell Biology
Regulation of mesenchymal stem cell quiescence, proliferation, and fate; osteoblast-adipocyte reciprocal differentiation; bone formation and regeneration; cell-extracellular matrix interactions
| Paul A. Janmey, Ph.D. |
Professor of Physiology
IME - 1010 Vagelos Labs
Defining PIP2 and other phosphoinositide-binding sites on proteins; cytoskeletal functions of MAP2 and tau; interactions among different cytoskeletal filaments.
| Peter Lloyd Jones |
Director, Penn/CMREF Center for Pulmonary Arterial Hypertension Research
Our research focuses on the role of homeobox gene transcription factors and their targets in lung development and disease, including pulmonary arterial hypertension and breast cancer metastasis to the lung vasculature.
Assistant Professor Department of Pathology School of Dental Medicine Assessing mechanisms of neuronal death (apoptosis vs necrosis in response to neuroinflammotry mechanisms and oxidative stress and protection by neurotrophins to gain insight into the molecular mechanisms underlying neuronal loss in neurodegenerative Disorders (i.e. Alzheimer's Disease, Parkinson's disease, and HIV encephalitis). We are specifically interested in the role of cell cycle proteins and transcriptional regulators in neuronal survival decisions. |
| Matthew J. Lazzara, Ph.D. | (215) 746-2264 |
Assistant Professor of Chemical and Biomolecular Engineering
Assistant Professor of Bioengineering
Member, Institute of Medicine and Engineering
311A Towne Building
Cellular engineering, cell signaling, receptor-ligand interactions and trafficking, molecular therapeutics, transport in biological systems.
| Daniel Lee, Ph.D. |
Associate Professor
Dept. of Electrical and Systems Engineering
Dept. of Bioengineering (Secondary)
GRASP (General Robotics, Automation, Sensing, Perception) Lab
Machine learning, computational neuroscience, adaptive signal processing, robotics, embedded real-time sensorimotor systems, multimodal sensory processing, motor learning, distributed multi-agent systems.
| John S. Leigh, Ph.D. |
Chief of Functional MR Research
Development and application of magnetic resonance techniques; optical imaging in highly scattering media, such as the human body; theoretical and experimental studies of protein folding and structure.
| Robert J. Levy, M.D. |
Interaction of biochemical concepts, pharmacology, pharmaceutics and biomaterials. Current projects in the laboratory are concerned with mechanisms of cardiac valve and blood vessel calcification, localized gene therapy for wound healing, myocardial implants for cardiac arrhythmia and primary syntheses of therapeutic polymers for biomaterial use.
| Robert M. Lewitt, Ph.D. |
Resarch Associate Professor of Radiology
Computer technology for medical imaging, in particular, the formulation and computer implementation of algorithms for image reconstruction from projection data, as derived from transmitted x-rays or emitted gamma rays.
| Brian Litt, M.D. | |
Assistant Professor of Neurology |
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| 3 West Gates | (215) 349-5166 |
My research focuses on my clinical work as a neurologist specializing in the care and treatment of individuals with epilepsy.
| Edward J. Macarak, Ph.D. |
Professor of Anatomy and Histology, School of Dental Medicine
Professor of Bioengineering
| 4th Flr. Levy Building | (215) 898-8993 |
Role of extracellular matrix in vascular, urologic and oral tissues. The role of mechanical forces in altering the behavior of cells in these tissues.
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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
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office: 215 746-8763 |
| Kenneth B. Margulies , M.D. |
Associate Professor of Medicine
Myocardial remodeling and reverse remodeling, Heart failure with preserved ejection fraction, E-C coupling and regulation of contractility, Endogenous cardiac repair, Natriuretic peptide biology
| Susan S. Margulies, Ph.D |
Professor of Bioengineering
Chair Bioengineering Graduate Group
Member, Institute for Medicine and Engineering
| 105D Hayden Hall | (215) 898-0882 |
Cell and tissue biomechanics, with emphasis on injury mechanisms and tolerances; pulmonary regional ventilation and ventilator-induced injury; spinal cord injury; pediatric and adult brain injury.
| Robert Mauck, Ph.D. | More Info |
Assistant Professor of Orthopaedic Surgery Assistant Professor of Bioengineering |
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| 424 Stemmler |
Engineering functional equivalents for musculoskeletal tissue engineering applications with particular focus on articular cartilage and meniscus. Mesenchymal stem cell mechanobiology and signal transduction in chondrogenic differentiation. Design of novel bioreactor systems to recapitulate the complex loading environment of diarthrodial joints.
Fabrication and application of anisotropic nanofibrous scaffold.
| Vadim Markel, Ph.D. |
Assistant Professor of Radiology
Professor of Bioengineering
Chair, Bioengineering
Member, Institute for Medicine and Engineering
| 105C Hayden Hall | (215) 573-3155 |
Biomechanics of central nervous system injury; evaluation of automotive crash dynamics and occupant restraints; experimental and computational modeling of brain and spinal cord injury mechanics.
| Vladimir Muzykantov, M.D., Ph.D. |
Drug/gene targeting and vascular biology.
| Steven Nicoll, Ph.D. | |
Assistant Professor of Bioengineering |
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| 111 Hayden Hall | (215) 573-2626 |
Connective tissue engineering, biomaterials, cartilage cell biology: Epigenetic Control of Cellular Phenotype; Biomimetic Scaffolds for Connective Tissue Repair; Transcriptional and Genetic Determinants of Chondrogenesis.
| Warren Pear, M.D., Ph.D. |
Tumor biology; signal transduction; leukemogenesis, including chronic myelogenous leukemia and myeloproliferative diseases; hematopoietic stem cell, biology.
| Ravi Radhakrishnan, Ph.D. | |
Assistant Professor of Bioengineering |
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| 540 Skirkanich Hall | (215) 898-0487 |
Computational biomolecular science and engineering, high performance computing, systems biology, carcinogenesis, RNA catalysis, immunology.
| Ravinder Reddy, Ph.D. |
Development of sodium and proton MRI based diagnostic tools for detecting early degenerative changes in cartilage.
| Virginia M. Richards, Ph.D. |
Human Auditory Perception, Psycophysics, and Mathematical Psychology.
| Rahim Rizi, Ph.D. |
Associate Professor, Department of Radiology
The goal of our research group is to develop research and clinical techniques capable of diagnosing a variety of pulmonary and metabolic disorders in their earliest stages, and of evaluating the lung's response to therapy.
| David Roos, Ph.D. |
Cell biology and molecular genetics of protozoan parasites: Toxoplasma and Plasmodium (malaria); eukaryotic evolution; computational biology.
| Casim A. Sarkar, Ph.D. | |
Assistant Professor of Bioengineering
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(215)573-4072 |
| 373 Towne Building |
Molecular cell engineering: rational design and directed evolution of proteins; cytokine/receptor binding and trafficking; cell signaling and decision-making; computational, synthetic, and systems biology
| James C. Saunders, Ph.D. |
Professor of Neuroscience
The structure and function of the peripheral auditory system, the micro and macromechanics of the middle ear, (tympanic membrane) and inner ear (hair cells); cellular activity in the peripheral auditory nervous systems; mechanism of hair cell transduction; signal processing in the cochlea; middle ear transmission.
| John C. Schotland, M.D., Ph.D. | |
Associate Professor of Bioengineering |
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| 311 Hayden Hall | (215) 898-8501 |
Optical tomography, near-field optics, inverse scattering, biomedical optics.
| Henry Shuman, Ph.D. |
Lipid transport, actomyocin interaction, molecular mechanism of anesthesia.
| Douglas H. Smith, M.D. |
Associate Professor of Neurosurgery
Modeling focal and diffuse brain injury, post-traumatic cognitive dysfunction, and traumatic axonal injury; techniques for diagnosis and treatment of brain trauma.
| Hee Kwon Song, Ph.D. |
Assistant Professor, Department of Radiology
| Louis J. Soslowsky, Ph.D. |
Professor of Orthopaedic Surgery
Professor of Bioengineering
Director of Orthopaedic Research
Member, Institute for Medicine and Engineering
| 424 Stemmler | (215) 898-8653 |
Orthopaedic biomechanics and tissue engineering, soft tissue mechanics, shoulder biomechanics, and joint biomechanics.
| Christian Stoeckert, Ph.D. |
Genomics unified schema used to itegrate sequence and its annotation from several sources and structure in a database; understand gene regulation and build models for genetic networks.
| Phong Tran, Ph.D. |
Generation of positional information within cells by the cytoskeleton
| Andrew Tsourkas, Ph.D. |
Assistant Professor of Bioengineering
Assistant Professor of Radiology
Member, Institute of Medicine and Engineering
| 110 Hayden Hall | (215) 898-8167 |
Development of novel molecular probes to image gene regulation, mRNA localization, protein expression, and enzymatic activity in vivo using fluorescence, bioluminescence, and magnetic resonance imaging approaches.
| Jayaram K. Udupa, Ph.D. |
Visualization and analysis of multi-dimensional biomedical images; computer graphics for medical applications; kinematics of joints from image sequences; and volume rendering.
| Ragini Verma, Ph.D. |
Research Assistant Professor
Section of Biomedical Image Analysis, Radiology
Biomedical image analysis specifically multi-parametric Magnetic Resonance image analysis and diffusion tensor imaging, facial expression analysis in neuropsychiatry
| Valerie M. Weaver, Ph.D. |
Member, Institute for Medicine and Engineering
Our laboratory studies the relationship between tissue architecture and the plasticity of gene expression. The present objective of our work is to delineate the molecular mechanisms driving malignant transformation of benign breast lesions, and to understand the pathophysiology of multi-drug resistant, metastatic breast cancer.
| Felix W. Wehrli, Ph.D. |
Quantitative medical magnetic resonance imaging.
| Rebecca Wells , Ph.D. | |
| Assistant Professor, Depts of Medicine and Pathology and Laboratory Medicine | |
215 573-1860 |
Liver fibrosis and in the mechanical and soluble factors (especially TGF-ß) that regulate liver fibrosis and the phenotype of fibrogenic cells in the liver.
| Beth A. Winkelstein, Ph.D. | |
Associate Professor of Bioengineering Associate Professor of Neurosurgery Member, Institute of Medicine and Engineering |
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| 108 Hayden Hall | (215) 573-4589 |
Biomechanics of painful neck injuries; mechanical and cellular mechanisms of pain onset and persistence; CNS neuroimmune responses of pain; cervical spine biomechanics; understanding the role of injury mechanics in the physiology of pain.
| Arjun Yodh, Ph.D. |
James M. Skinner Professor of Science
Professor of Physics & Astronomy
Fundamental and applied condensed matter physics, biomedical optics & biophysics, and optical science. Current research includes: soft materials, complex fluids & networks, carbon nanotubes, optical microscopy & micromanipulation, biomedical optics, functional imaging & spectroscopy of living tissues, photodynamic therapy and nonlinear optics.
Radiology /Molecular Imaging Laboratory
Develop and implement molecular imaging approaches to study cancer and cardiovascular diseases. Specific projects include stem cell based cardiac regeneration, cardiac kinematics using magnetic resonance (MR) imaging based techniques, and study of tumor microenvironment by MR imaging and spectroscopy.
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