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Credit: 1 course unit
Required course (Junior year)
Catalog
Description:
This course aims to provide theoretical, and conceptual principles underlying biomolecular and biological systems. The course will start with basic and advanced concepts in physical chemistry and thermodynamics and introduce statistical mechanics as a tool to understand molecular interactions. The applications will be of relevance to bioengineering and biology disciplines. The course will not shy away from mathematical formulations and will stress the molecular perspective.
Prerequisites:
Physics 140 or 150, Phys 141 or 151, Math 240, Chemistry 101, 102.
Textbook(s) and/or
other materials:
Required:
Molecular Driving Forces by K. A. Dill and S. Bromberg Taylor and Francis publications ISBN: 0-8153-2051-5 Paperback edition
Reference:
(1) Raymond Chang, PHYSICAL CHEMISTRY for the chemical and biological sciences,University Science Books, 2000
(2) Biological Physics Energy, Information, Life by Philip Nelson ISBN: 0-7167-4372-8
(3) Quantum Theory (Paperback)
David Bohm, ISBN: 0486659690 Dover Publications
Course Objectives
and Relation to Program Objectives:
To provide a rigorous introduction to the topics listed below using math at the advanced calculus/differential eqn level, general physics- mechanics, electricity and magnetism, general chemistry- atomic structure, chemical bond, thermodynamics, kinetics, and to illustrate these topics with examples from physiology and bioengineering.
Topics Covered:
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Formulation of Thermodynamics in terms of energy, entropy, and free energy
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Microscopic definition of heat, work, free energy, and laws of thermodynamics, Boltzmann distribution
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Formulation of Quantum Mechanics
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Applications to ideal gas, crystals, complex biological molecules
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Thermodynamics of liquids and liquid mixtures, surface tension
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Intermolecular interactions and forces
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Advanced topics and applications: Self assembly, hydrophobic effect, polymers, chemical kinetics, drug design, binding and recognition
Class Schedule:
Lecture: 3 hrs/week
Recitation: 1 hr/week
Contribution
towards Professional Component:
100% Engineering science
Contribution
towards Program Outcomes:
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Multidisciplinary
Ability
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High
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Problem Solving
Approach
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High
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Problem Solving
Methods
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High
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Experimentation
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Low
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Design
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Low
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Professional
Orientation
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Low
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Person Preparing
Description and Date:
Ravi Radhakrishnan
July 2007
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