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Credit: 1 course unit
Elective course
Catalog
Description:
Development of concepts about the operation of the mammalian
cardiovascular system as conceived in the years 198
(by Galenus, personal physician to Roman Emperor Marcus Aurelius), 1628, (by
Willaim
Harvey in his book "De motu cordis et sanguinis
), and 1998
(At Penn by Abraham Noordergraf).
Prerequisites:
BE 350 or equivalent, or permission of
the instructor.
Textbook(s) and/or
Other Required Materials:
Noordergraaf: Circulatory System Dynamics, Academic Press,
1978. (This book has been sold out, but the SEAS Copy
Center provides
copies at cost.)
Noordergraaf: Blood in Motion, to be published by Springer Verlag, NY (Preprints of most chapters will be made
available as handouts.)
Course Objectives:
To train students in quantitative analysis of the cardiovascular
system and its components, as currently conceived.
Comprehend the difference between modeling and simulation.
Understand the age old tension between theory and experiment.
Topics Covered:
Muscle structure and mechanical properties; the single band
structure of the two ventricles; electrical stimulation;
Frank’s mechanism; the mathematical description of the heart as a
pump; ventricular load and venous supply; the impedance-defined flow
principle; wave transmission in arteries; collapse of veins; the
influence of respiration and ambulation; effect of gravity; the
microcirculation as the site of communication with extra-vascular
tissues; generalization of the Starling hypothesis; the closed system;
control theory with specific applications in the circulatory system;
transplanted and artificial hearts.
Class/Laboratory
Schedule:
Lecture: 3hr/week
Contribution
towards Professional Component:
100% Engineering science
Contribution
towards Program Outcomes:
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Multidisciplinary
Ability
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High
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Problem Solving
Approach
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Med.
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Problem Solving
Methods
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Med.
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Experimentation
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Med.
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Design
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Low
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Professional
Orientation
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High
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Person(s) Preparing
Description and Date:
Abraham Noordergraaf, Ph.D.
July 2007
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