|
Credit: 1 course
unit
Elective course (Junior or senior
year)
Catalog Description:
This course will provide a comprehensive survey of modern medical
imaging modalities with an emphasis on the emerging field of molecular
imaging. The basic principles of
X-ray, computed tomography, nuclear imaging, magnetic resonance imaging,
and optical tomography will be reviewed.
The emphasis of this course, however, will focus on the concept of
contrast media and targeted molecular imaging. Topics to be covered include the
chemistry and mechanisms of various contrast agents, approaches to
identifying molecular markers of disease, ligand
screening strategies, and the basic principles of toxicology and
pharmacology relevant to imaging agents.
Prerequisites:
BIOL 215 Vertebrate Physiology, or BE 305 Engineering Principles of
Human Physiology, or permission of instructor.
Textbook(s) and/or other
materials:
Course notes, handouts, journal articles
Reference Books:
1. Chemistry, 3rd Edition, Steven S. Zumdahl, D.C. Heath and Company, 1993
2. Medical Imaging Physics, 4th Edition, William R. Hendee, E. Russell Ritenour, Wiley-Liss, 2002
3.
Textbook
of Contrast Media, P. Dawson, D. Cosgrove, D. Allison, R.G. Grainger,
T&F STM, 1999
4.
Introduction
to Biomedical Imaging (IEEE Press Series on Biomedical Engineering), A.
G. Webb, Wiley-IEEE Press, 2002
5. MRI the basics, Ray H. Hashemi, William G. Bradley, Jr., Lippincott Williams & Wilkins, 1997
6.
Handbook of Targeted Delivery of Imaging Agents, Edited by Vladimir P. Torchilin, CRC Press, 1995
Course Objectives:
First, to provide overview of basic principles of X-ray, computed
tomography, nuclear imaging, magnetic resonance imaging, and optical
tomography. Second, to introduce basic principles of contrast media and
molecular imaging.
Topics covered:
- Molecular imaging
- X-ray and Computed Tomography
- Nuclear Imaging fundamentals
- Principles of Ultrasonic Imaging
Ultrasound contrast agents
- Principles of Magnetic Resonance Imaging
- Contrast mechanisms in MRI
- Principles of fluorescence
- Targeted delivery of imaging reagents
- Identification of molecular markers of
Pharmacology principles
- Toxicology
- Testing contrast agents in humans
Contribution towards Professional Component:
100% Engineering science
Contribution
towards Program Outcomes:
|
Multidisciplinary
Ability |
High. |
|
Problem Solving
Approach |
Low |
|
Problem Solving
Methods |
Low |
|
Experimentation |
Low |
|
Design |
Med. |
|
Professional Orientation |
Low |
Person Preparing
Description and Date:
Andrew Tsourkas
July 2007
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