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Credit: 1 course unit
Elective course
Catalog Description:
This course provides a comprehensive background in
biomaterials. It covers surface properties, mechanical behavior and
tissue response of ceramics, polymers and metals used in the body.
It also builds on this knowledge to address aspects of tissue
engineering, particularly the substrate component of engineered tissue
and organs.
Textbook(s) and/or
Other Required Materials:
Readings materials and handouts will be selected from journal articles and the recommended texts listed below.
Biomaterials Science: An Introduction to Materials in Medicine, B. D. Ratner, A. S.
Hoffman, F. J. Schoen, and J. E. Lemons (eds.), Academic Press, San
Diego, 1996.
Callister, W. D., Materials Science and Engineering: An Introduction,
5th ed., John Wiley and Sons, New York, 2000.
Black, J., Biological Performance of Materials: Fundamentals of
Biocompatibility, 3rd ed., Marcel Dekker,
New York,
1999.
Principles of Tissue Engineering, R. P. Lanza, R. Langer, W. L. Chick
(eds.), Academic Press, San Diego, 1997.
Course Objectives:
This course will provide a comprehensive introduction to materials
used for biomedical applications, focusing on both atomic structure and
macroscopic bulk properties of the major classes of materials, as well as
issues of biocompatibility and biological responses to implantable
materials. As such, students are expected to gain an understanding of the
materials selection and design criteria required for engineering living
tissue equivalents. The first portion of the course will consist of
an introduction to materials science and engineering, focusing on
traditional classes of materials used for biomedical applications (i.e.,
metals, ceramics, polymers, and composites). Students will be exposed
to the multidisciplinary nature of biomaterials as the course will
incorporate aspects of materials science and engineering, the life
sciences and clinical medicine. The remaining sections will
deal with issues of biocompatibility and biological responses to
materials, followed by selected topics on emerging technologies such as
gene delivery and nanofabrication/bioMEMs. The
course will also allow students to develop an appreciation for important
design criteria relevant to the biomedical implant industry.
Course Topics:
Introduction, Bonding, Bulk Properties, Metals, Structure, Metals:
Properties; Fabrication, Ceramics: Structure, Ceramics: Properties;
Fabrication, Polymers: Structure, Polymers: Properties; Fabrication,
Biodegradable Polymers, Composites, Natural Materials, Surface
Properties; Adsorption, Cell Adhesion
Cell-ECM/Substrate Interactions, Biocompatibility; Inflammation,
Immunological Responses, Hypersensitivity; Hemocompatibility,
Implant-Associated Infection; Sterilization, Degradation, Corrosion;
Wear, Surface Characterization, Surface Modification, Nanofabrication; BioMEMs, Drug Delivery; Gene Insertion/Therapy;
Review
Class/Laboratory
Schedule:
Lecture: 3 hr/week
Contribution
towards Professional Component:
100% Engineering science
Contribution
towards Program Outcomes:
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Multidisciplinary
Ability
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Med.
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Problem Solving
Approach
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Med.
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Problem Solving
Methods
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Low
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Experimentation
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Med.
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Design
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Low
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Professional
Orientation
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Low
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Person Preparing
Description and Date:
Jason Burdick
July 2007
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