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Credit: 1 course unit
Elective course
Catalog
Description:
Principles,
Methods, and Applications of Tissue Engineering. Tissue engineering demonstrates enormous
potential for improving human health. While there is an extensive
body of literature discussing the state of the art of tissue engineering,
the majority of this literature is descriptive and does little to address
the principles that govern the success or failure of an engineered
tissue. This course explores principles of tissue engineering, drawing
upon diverse fields such as developmental biology, immunology, cell
biology, physiology, transport phenomena, material science, and polymer
chemistry. Current and developing methods of tissue engineering as
well as specific applications are discussed in the context of these
principles.
Prerequisites:
Graduate Standing or instructor’s permission.
Textbook(s) and/or Other Required Materials:
Primarily research and reviews articles from scientific journals.
Additional materials will be compiled from other texts.
Course Objectives:
This course is an elective for bioengineering
and is also offered to Masters and Ph.D. students. The objective of
the course is to provide the student with basic tools and skills
necessary to model biological systems. The course aims to teach
basic skills, and apply them to a range of areas within bioengineering,
giving the student a broad overview of the applications of modeling in
biology. Subject areas covered in the course will include model
selection and validation, statistics, and fundamentals of Matlab.
Topics Covered:
- Natural examples of Tissue Engineering:Embryogenesis and Development;
Embryonic and Adult Stem Cells; Cellular differentiation; Remodeling
and Wound Healing; Tissue Regeneration
- Factors controlling cell and tissue growth
and differentiation: Cell Shape; Growth Factors; ECM; Cell-cell
interactions; Mechanical forces; Transport; Gene expression
- Applications of Tissue Engineering.
Example applications:Bone, Cartilage,,
Small-diameter vascular grafts, Heart tissue, Liver, Islets,
Peripheral nerve regeneration
Class/Laboratory Schedule:
Lecture: 3 hrs/week
Contribution
towards Professional Component:
100% Engineering science
Contribution
towards Program Outcomes:
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Multidisciplinary
Ability
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High
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Problem Solving Approach
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Low
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Problem Solving
Methods
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Low
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Experimentation
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Med.
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Design
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Low
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Professional
Orientation
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Low
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Person(s) Preparing
Description and Date:
Keith Gooch
November 2003
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