BE584   Mathematics of Medical Imaging and

             Measurement


Bioengineering Undergraduate Program

 

 

 

 

Credit: 1 course unit

 

Elective course

 

Catalog Description:

 

In the last 25 years there has been a revolution in image reconstruction techniques in fields from astrophysics to electron microscopy and most notably in medical imaging.  In each of these fields one would like to have a precise picture of a 2 or 3 dimensional object, which cannot be obtained directly. The data that is accessible is typically some collection of weighted averages.  The problem of image reconstruction is to build an object out of the averaged data and then estimate how close the reconstruction is to the actual object.  In this course we introduce the mathematical techniques used to model measurements and reconstruct images.  As a simple representative case we study transmission X-ray tomography (CT).In this context we cover the basic principles of mathematical analysis, the Fourier transform, interpolation and approximation of functions, sampling theory, digital filtering and noise analysis.

 

Prerequisites:

 

Mathematics through multivariate calculus (Math 241), as well as some familiarity with linear algebra and basic physics.

 

Textbook(s) and/or other Required Material:

 

Introduction to the Mathematics of Medical Imaging, by Charles L. Epstein, Prentice Hall, 2003.

 

Topics Covered:

 

  • Mathematical models and measurement.
  • Linear equations and an introduction to function spaces.
  • Integral transforms: the Fourier transform, the Radon transform, the Abel transform, convolution.
  • Sampling and digitization, interpolation and approximation.
  • Nyquist's theorem and basic concepts of signal processing.
  • Implementing shift invariant filters.
  • Imaging hardware and the basic algorithms of image reconstruction.
  • Analysis of systematic artifacts.
  • Introduction to probability and statistics
  • Analysis of noise in tomography.

 

Class/Laboratory Schedule:

 

Lecture: 3 hr/week

 

Course Objectives:

 

The goal of this course is to introduce the mathematical  techniques underlying most signal and image processing in a manner that will allow the students to see the big picture. While the course is constructed around the analysis of X-Ray computed tomography, the intention is to provide tools that can be applied to essentially any imaging modality. 

 

Contribution towards Professional Component:

 

100% Engineering science

 

Contribution towards Program Outcomes:

 

Multidisciplinary Ability

High

Problem Solving Approach

High

Problem Solving Methods

High

Experimentation

Low

Design

Low

Professional Orientation

Low

 

Person(s) Preparing Description and Date:

 

Charles L. Epstein

August 2007