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Britton Chance Distinguished Lecture in Engineering and Medicine

The 2009 Britton Chance Distinguished Lecture in Engineering and Medicine sponsored by the Department of Chemical and Biomolecular Engineering and the Institute for Medicine and Engineering.

Nanoparticle Cancer Therapeutics: From Concept to Clinic

Mark E. Davis

Warren and Katharine Schlinger Professor of Chemical Engineering, California Institute of Technology, and Member, City of Hope Comprehensive Cancer Center, Experimental Therapeutics Program

Monday, October 26, 2000, 3:00 PM
Wu and Chen Auditorium
Levine Hall, 3330 Walnut Street

a reception will follow the lecture

Abstract

Nanoparticle-based therapeutics containing either small molecule anti-cancer agents or siRNA are described. Relationships between nanoparticle design and function in animal models are described in detail. Results from human clinical trials are presented and compared to those obtained from animal studies. Nanoparticle-based therapeutics are shown to provide interesting behavior in humans.

Mark E. Davis is the Warren and Katharine Schlinger Professor of Chemical Engineering at the California Institute of Technology and a member of the Experimental Therapeutics Program of the Comprehensive Cancer Center at the City of Hope. He has over 350 scientific publications, two textbooks and over 50 patents. Professor Davis is a founding editor of CaTTech and has been an associate editor of Chemistry of Materials and the AIChE Journal. He is the recipient of numerous awards including the Colburn and Professional Progress Awards from the AIChE and the Ipatieff, Langmuir and Murphree Prizes from the ACS. Professor Davis was the first engineer to win the NSF Alan T. Waterman Award. He was elected in the National Academy of Engineering in 1997 and the National Academy of Sciences in 2006. Professor Davis’ research efforts involve materials synthesis in two general areas; namely, zeolites and other solids that can be used for molecular recognition and catalysis, and polymers for the delivery of a broad range of therapeutics. He is the founder of Insert Therapeutics Inc., a company that focused on the use of cyclodextrin-containing polymers for drug delivery applications and Calando Pharmaceuticals, Inc. a company based in Pasadena, CA USA that created the first RNAi therapeutic to reach the clinic for treating cancer. He has been a member of the scientific advisory boards of Symyx (Nasdaq: SMMX) and Alnylam (Nasdaq: ALNY). Professor Davis has achieved All American Status for Masters Track and Field in both the 400 Meter and 200 Meter Dashes.

Britton Chance, Eldridge Reeves Johnson University Professor Emeritus of Biophysics, Physical Chemistry and Radiologic Physics at the University of Pennsylvania, is one of the world’s leaders in transforming theoretical science into useful biomedical and clinical applications. Examples of his pioneering contributions to fundamental biomedical science are his discovery of numerous enzyme-substrate compounds, World War II development of computers for Radar, the elucidation of the fundamental principles of control of bioenergetics and metabolism, the first human subject study using ³¹P NMR (phosphorous nuclear magnetic resonance) spectroscopy and more recently optical spectroscopy and imaging of human brain and breast. Through decades of scholarly mentorship of colleagues in disciplines ranging from mathematics to clinical medicine, he has brought additional distinction to this University and multiplied its contributions to improving the human condition.
           Professor Chance received his undergraduate degree from Penn’s Towne Scientific School in 1935 and his doctoral degrees from both Penn and the University of Cambridge. He is a member of the National Academy of Sciences and of the Institute of Medicine and is a Foreign Member of the Royal Society of London. Among very many other recognitions, he has received the National Medal of Science, the Benjamin Franklin Medal from the American Philosophical Society, the Biological Physics Prize from the American Physical Society, and honorary degrees from the Karolinska Institut, the Medical College of Ohio at Toledo, Semmelweis University, Hahnemann Medical College and the Universities of Pennsylvania, Helsinki, Dusseldorf and Buenos Aires.

Previous Britton Chance Distinguished Lecturers