Harvey Rubin

Professor of Medicine and
Computer and Information Science (CIS)

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Research Expertise: Molecular Engineering | Bioengineered Therapeutics | Devices and Drug Delivery

Harvey's laboratory at Penn's School of Medicine researches the genetic and biochemical mechanisms involved in the pathophysiology of Mycobacterium tuberculosis and other bacteria. Harvey's research has extended basic biochemistry and molecular biology research to the mathematical modeling of complex biological systems. Working to develop new approaches to understanding the dynamically reorganizing and networked systems that represent microbial life, Harvey and his students examine the integration of positive and negative feedback loops that can lead to multiple steady states, and investigate cell fate decisions where cells can exhibit stochastic behavior transitioning between these steady states. One specific example of this persistence is the adaptive mechanism that bacteria use to survive and repopulate in stressful environments.

Education:
PhD - University of Pennslyvania
MD - Columbia University College of Physicans and Surgeons

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