Harvey Rubin
Professor of Medicine and
Computer and Information Science (CIS)
Research Expertise: Molecular Engineering | Bioengineered Therapeutics | Devices and Drug Delivery
Harvey's laboratory at Penn's School of Medicine researches the genetic and biochemical mechanisms involved in the pathophysiology of Mycobacterium tuberculosis and other bacteria. Harvey's research has extended basic biochemistry and molecular biology research to the mathematical modeling of complex biological systems. Working to develop new approaches to understanding the dynamically reorganizing and networked systems that represent microbial life, Harvey and his students examine the integration of positive and negative feedback loops that can lead to multiple steady states, and investigate cell fate decisions where cells can exhibit stochastic behavior transitioning between these steady states. One specific example of this persistence is the adaptive mechanism that bacteria use to survive and repopulate in stressful environments.
Education:
PhD - University of Pennslyvania
MD - Columbia University College of Physicans and Surgeons
Recent Publications 
- The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence, Thayil, S.M. | Morrison, N. | Schechter, N. | Rubin, H. | Karakousis, P.C., PLoS ONE, 2011
- Rapid analysis of pharmacology for infectious diseases, Hopkins, A.L. | Richard Bickerton, G. | Carruthers, I.M. | Boyer, S.K. | Rubin, H. | Overington, J.P., Current Topics in Medicinal Chemistry, 2011
- Reduction of clofazimine by mycobacterial type 2 NADH: Quinone Oxidoreductase: A pathway for the generation of bactericidal levels of reactive oxygen species, Yano, T. | Kassovska-Bratinova, S. | Shin Teh, J. | Winkler, J. | Sullivan, K. | Isaacs, A. | Schechter, N.M. | Rubin, H., Journal of Biological Chemistry, 2011
- An enforceable international compact for infectious diseases: Strategies to operationalize new initiatives to strengthen global health security, Rubin, H. | Kameswara Rao, C., Current Science, 2009
- Characterization of nucleotide pools as a function of physiological state in Escherichia coli, Buckstein, M.H. | He, J. | Rubin, H., Journal of Bacteriology, 2008