Casim A. Sarkar
Assistant Professor
Bioengineering (BE)
Chemical and Biomolecular Engineering (CBE)
Honors and Awards: NSF CAREER Award - 2011
Research Expertise: Cellular Engineering | Bioengineered Therapeutics | Devices and Drug Delivery | Systems Biology
Sarkar strives to elucidate fundamental principles that underlie individual biomolecular interactions and molecular networks within cells and to apply this knowledge to the design of new molecular and cellular therapeutics. His research couples techniques from the fields of molecular biology, protein biochemistry, microbiology, and mammalian cell biology with mathematical modeling, engineering analyses, and synthetic biology to develop quantitative, predictive frameworks for the biological processes that he interrogates. Current thrusts in Sarkar's laboratory include designing novel protein therapeutics, engineering cell biosensors, and dissecting signaling networks implicated in cell decision making.
Member of:
Education:
PhD Chemical Engineering 2002 - Massachusetts Institute of Technology
BS Chemical Engineering 1997 - University of Texas
Recent Publications 
- Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated igg displaying high FcγRIIa affinity and selectivity, Jung, S.T. | Kelton, W. | Kang, T.H. | Ng, D.T.W. | Andersen, J.T. | Sandlie, I. | Sarkar, C.A. | Georgiou, G., ACS Chemical Biology, 2013
- Streamlined protocol for mRNA display, Barendt, P.A. | Ng, D.T.W. | McQuade, C.N. | Sarkar, C.A., ACS Combinatorial Science, 2013
- Engineering signal peptides for enhanced protein secretion from Lactococcus lactis, Ng, D.T.W. | Sarkar, C.A., Applied and Environmental Microbiology, 2013
- Analyzing and engineering cell signaling modules with synthetic biology, O'Shaughnessy, E.C. | Sarkar, C.A., Current Opinion in Biotechnology, 2012
- Model-guided ligation strategy for optimal assembly of DNA libraries, Ng, D.T.W. | Sarkar, C.A., Protein Engineering, Design and Selection, 2012