MSE 430

: Polymers and Biomaterials (Spring 2005)
(Also CBE 430, MSE 580, CBE530)
Term Offered: Spring
Text(s): Introduction to Polymers, by R. J. Young and P. A. Lovell
2nd Ed. (1991), Chapman & Hall, ISBN: 0412221802
CRC press (in stock), List Price: $49.95, Cat. #: NT1150

And
Contemporary Polymer Chemistry by Harry R. Allock, Frederick W. Lampe and James E. Mark
3rd edition (2003), Pearson Education, Inc.; ISBN: 0-13-065056-0

Need another good textbook on polymer structure-property, rheology?

Handouts from:
Principles of Polymerization by George Odian
3rd Ed. (1991), Wiley-Interscience, ISBN: 0471610208
4th Ed. (Jan. 2004), Wiley-Interscience, ISBN: 0471274003

The Physics of Block Copolymers by Ian W. Hamley
Oxford University Press; ASIN: 0198502184

Polymers at Surfaces and Interfaces by Richard A. L. Jones and Randal W. Richards
Cambridge University Press; ISBN: 0-521-47965-7
(Physical Chemistry of Surfaces by Arthur W. Adamson and Alice Gast)

Handbook of Biodegradable Polymers (Drug Targeting and Delivery) edited by A. J. Domb, Joseph Kost, and David M. Wiseman
Publisher: Martin Dunitz, Ltd. (February 1998); ISBN: 9057021536

Instructor(s): Instructor: Shu Yang, 203 LRSM, shuyang@seas.upenn.edu, 898-9645
Prerequisite(s): MSE 330 or permission by instructor
Grading: Undergrad Graduate
Homework assig(~10) 20% Homework assignment (~10) 15%
Exam I 20% Exam I 20%
Exam II 20% Exam II 20%
Final Exam 40% Final Exam 35%
Special topic presentation 10%
Course Home Page URL:  
Course Description: This course focuses on synthesis, characterization, microstructure, rheology, and structure-property relationships of polymers, polymer directed composites and their applications in biotechnology. Topical coverage includes: polymer synthesis and functionalization; polymerization kinetics; structure of glassy, crystalline, and rubbery polymers; thermodynamics of polymer solutions and blends, and crystallization; liquid crystallinity, microphase separation in block copolymers; polymer directed self-assembly of inorganic materials; biological applications of polymeric materials. Case studies include thermodynamics of block copolymer thin films and their applications in nanolithography, molecular templating of sol-gel growth using block copolymers as templates; structure-property of conducting and optically active polymers; polymer degradation in drug delivery; cell adhesion on polymer surface in tissue engineering.

Course Outline: 1. Introduction: Review of polymers taught in MSE 330: (1 lecture)
Polymer nomenclature
Chemical structure-property relationship

2. Synthesis and kinetics (11 lectures)
Step growth polymerization
Radical chain polymerization
Living free radical polymerization
Ionic polymerization
Metathesis
Copolymerization
Hyperbranched and dendritic polymers
Network formation
Molecular weight and distribution: gel permeation chromatography, mass spectroscopy (MALDI-TOF), intrinsic viscosity, light scattering, osmometry
Thermal characteristics: Tg, Tm, Tc by DSC (or can be in individual topics)
Case study: synthesis of random and block copolymers of poly(styrene) and poly(methyl methacrylate)

Exam I

Polymer solution (3 lectures)
Solvent quality
Flory-Huggins theory
Critical solution temperatures: LCST and UCST (example: polyacrylamide)

Structure and Morphology of Condensed States (10 lectures)
Glassy vs. rubbery states
Crystallization: spherulites and semicrystalline polymers
Case study: directed crystal growth of conducting polymers and their application in transistors
Multicomponent systems
Thermodynamics of phase separation in block copolymers
Block copolymer thin films: morphology and thermodynamics on surface
Case study: nanopatterning of semiconductors using block copolymer templates
Polymer blends and alloys: phase separation
Polymer directed inorganic nanocomposites
Properties: strengthening, toughening of materials
Case study: block copolymer templated mesoporous silicates

Exam II

Polymer surface (4 lectures)
Surface functionalization: physisoption, radiation grafting, silane chemistry
Surface properties: surface energy, contact angle, packing, roughness, hysteresis
Switching of surface properties
Case study: cell adhesion on surface in tissue engineering or "lotus leave effect"

Rheology (5 lectures)
Intrinsic viscosities, Polymer chain conformation (radius of gyration)
Thermal effects of rheological behavior
Time temperature equivalence, WLF equation, Arrhenius behavior
Viscoelasticity, Boltzmann's superposition principle
Polymer processing/fabrication

Polymer Degradation (4 lectures)
Mechanism of polymer degradation and elimination
Biodegradable polymers
Degradation in biological systems
Case study: biopolymer degradation in drug targeting and delivery
 


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