University of Pennsylvania
School of
Engineering and Applied Science
Department of Bioengineering
Bioengineering Senior Design (BE495-96)
Fall 2000 & Spring 2001
This course is a two-semester course for seniors in Bioengineering to complete a design project under the administration of an advisor.
The Global advisor is Dr. Kenneth Foster and the TA is Dan Pincus.
STUDENTS ARE EXPECTED
TO CHECK courseweb.upenn.edu
FOR COURSE INFORMATION, DUE DATES, AND PAPER OUTLINES.
|
Project Advisor |
Project Title |
Project Description |
Student(s) |
|
Dr. Daniel Bogen |
Diagnostic "Toys" to measure cognitive function in children with head injury and cerebral palsy. (Up to 6 Students) |
Description Not Available |
Barry Lee Joyce Yang Seema Patel Akshay Sateesh Patrick Lee Ajay Abad |
|
Dr. Kristy Arbogast |
Occupant protection for sleeping children. (Up to 2 Students) |
Research has shown that serious injuries and fatalities can be prevented in motor vehicle crashes with the use of seat belts and child restraint devices. However, those restraint systems are developed using crash dummies who sit in perfect upright position. Realistically, however, passengers do not always sit forward facing and upright. One example of this is children's desire to sleep in vehicles, especially, on long trips. Current restraint systems make this difficult and the awkward positioning of a seat belt compromises the effectiveness of the restraint system. The objective of this project is to design a restraint system that would be comfortable for children of seat belt age to sleep in and also be protective in the event of a crash. |
Audrey
Rosales Corinne Simon |
|
Dr. J. Baumgardner |
Design of Device for Collecting Mixed Expired Gases (Student Initiated Project) |
Description Not Available |
Julia Wisniewski |
|
Dr. Gershon
Buchsbaum |
Application of visual system image. sampling, coding and representation and their application. (1 Student) |
Simulation methods based on anatomy and neurophysiology are used to quantify visual system design principles and applied to develop image processing strategy and methodologies. |
1 |
|
Dr. Britton Chance |
Functional brain activation in response to learning stimuli using electroptics technologies. (1 Student) |
The currently available prefrontal imager has the capability of distinguishing the blood volume responses to learning and to a learned response. The students will use signal processing and imaging display technologies and participate in human subject studies under IRB protocols. |
Matthew
Samuelowitz |
|
Dr. Britton Chance |
The design of a portable
NIR imager for skeletal muscle. (1 Student) |
The possibility of imaging localized deoxygenation of human skeletal muscle offers an opportunity to develop new instrumentation and new approaches to muscle study using sophisticated signal processing and image display algorithms. |
1 |
|
Dr. Britton Chance |
Monitoring attention in the human brain in "drivers". NIR optical image respond to brain function. (1 Student) |
Design and construal of a system that automatically indicate attentive responses of alarm for inattention. |
1 |
|
Dr. Britton Chance |
Design of an algorithm for quantitative measurements of NIR contrast agents in tissue. (1Student) |
Description Not Available |
1 |
|
Dr. Scott Diamond |
Device for specialized drug delivery (Student initiated project) |
The project seeks to
understand the design parameters of an ultrasound |
Jeffrey D.
Gross |
|
Dr. Dennis Discher |
Atomic force microscopy experiments on single molecules. (Up to 2 Students) |
What does a molecule feel like when you touch it and pull on it? We are doing just that to single protein molecules using AFM. The work is relevant to cell, molecular and tissue engineering. |
1 |
|
Dr. Dennis Discher |
Polymers for drug and gene capsules and also synthetic cells. (Up to 2 Students) |
How do you engineer a membrane-bound microbag? We are extending our synthesis and extensively characterizing molecularly-assembled capsules that we already know to be incredibly durable and potentially important to new therapies. |
Gregory J.
Moy |
|
Dr. Paul Ducheyne |
Design and testing of controlled drug release materials. (Up to 2 Students) |
Description Not Available |
Melanie Gnazzo Walter Blair Aughenbaugh |
|
Dr. Paul Ducheyne1 |
Validation of an osteoblast cell-stressing device. (1 Student) |
Description Not Available |
1 |
|
Dr. David Eckmann |
Automatic infusion delivery system for trauma resuscitation. (Up to 2 Students) |
The Institute for Medicine has recommended that the initial trauma resuscitation for battlefield injury be 250 cc of 7.5% saline solution delivered rapidly through an interosseous needle. The students will design a transportable, compact, and self-contained delivery system that can be used for this purpose. |
Beney J. Lee |
|
Dr. Dawn Elliott |
Tissue Remodeling in a Tendon Explant Culture (Up to 2 Students) |
Design and fabricate system to apply controlled static and dynamic forces to tendon explants in a culture environment. |
Adrianne
Wenisch |
|
Dr. James Gee |
Computational methods for MRI morphometry. (Up to2 Students) |
Design, Implement and evaluate algorithms for quantitative characterization of anatomy as revealed on hi-resolution MRI studies. |
Cristian
Jurau |
|
Dr. Daniel Hammer |
Design of an artificial
leukocyte. (Up to 2 Students) |
By attaching adhesion ligands to polymersomes, students will attempt to make an artificial while blood cell that can rollover endothelium under flow. |
1 |
|
Dr. Peter Joseph |
Deconvolution of phosphor (1Student) |
Description Not Available |
1 |
|
Dr. Mitchell Litt |
Development of a testing apparatus for controlled studies of acupuncture effectiveness. (Up to 2 Students) |
Description Not Available |
Yvonne Chen Ameesha Patel |
|
Dr. Edward J.
Macarak |
Design of an apparatus to apply hydrostatic pressure to several types of smooth muscle cells and evaluate their response. (1Student) |
Description Not Available |
1 |
|
Dr. David Meaney |
Construction of a three-dimensional model of agarose and embryonic cells for testing under compressive loading. (Up to 2 Students) |
Description Not Available |
1 |
|
Dr. Joseph McGowan |
MR-compatible virtual reality goggles for functional brain imaging. (Up to 2 Students) |
Description Not Available |
Janine Lupo Likang Chin |
|
Dr. Joseph McGowan |
Development and optimization of radio frequency probes for imaging mice with MRI. (Up to 2 Students) |
Description Not Available |
1 |
|
Dr. Joseph McGowan |
Development and optimization of restraint, support and anesthesia systems for imaging mice with MRI. (Up to 2 Students) |
Description Not Available |
1 |
|
Dr. Tracy McIntosh |
Analysis of functional neurological defects. (Up to 2 Students) |
Design and construct/modify a device to evaluate neurological motor defects in rats and mice. |
Tamar
Mirensky |
|
Dr. Tracey McIntosh 1 |
Brain surface sensor. (Up to 2 Students) |
To construct a device to locate the position of a metal rod relative to the surface of the brain. |
1 |
|
Dr. David Nunamaker |
Fish trap: Design, manufacture and testing. (Up to 2 Students) |
Pond aquaculture has a need for a method of harvesting fish that doesn't rely on draining ponds. The fish trap must attract and retain fish for sampling or harvest without injury and allow grading for size. |
1 |
|
Dr. Enyi Okereke |
Design of an unconstrained total ankle prosthesis (Up to2 Students) |
Description Not Available |
Dinh Vu Grace Doe |
|
Dr. Harold Riethman |
Development of DNA chips for micro array analysis. (Up to2 Students) |
Conditions for arraying DNA fragments at average spacing of 350 microns will be optimized using a robotic arraying device. RNA from tumor specimens will be analyzed to determine the quantitative levels of individual RNA's by hybridization to the 5000-element micro array grid. |
1 |
|
Dr. Harold Riethman |
Design and analysis of
nanostructures formed by (1 Student) |
Description Not Available |
1 |
|
Dr. David A. Roberts,
M.D., Ph.D. 215-662-4034 |
Development of intravascular coils for use in magnetic resonance imaging angiography. (1 Student) |
Description Not Available |
1 |
|
Dr. David A. Roberts,
M.D., Ph.D. 215-662-4034 |
Construction of dedicated coils for imaging of hyperpolarized helium gas ventilation. (1 Student) |
Description Not Available |
1 |
|
Dr. David A. Roberts,M.D.,
Ph.D. 215-662-4034 |
Evaluation of MR Characteristics of implantedvascular devices (e.g., stents, grafts, etc.) (1 Student) |
Description Not Available |
1 |
|
Dr. Peter Scherer Dr. Susan Margulies |
Design of concentration/flux cell for testing/exposing respiratory epithelial cells to pollutant flow. (Up to2 Students) |
Design and construct plastic flat-plate cell to deliver and expose respiratory epithelial cells to pollutants. |
1 |
|
Dr. Peter Scherer |
Math modeling blood velocity and pressure during vent ejection. (Up to 2 Students) |
Theoretical modeling of blood velocity and pressure intra ventricularly during cardiac ejection and comparison with clinical and experimental measurements and other calculations. |
1 |
|
Dr. H. Ralph Schumacher,
Jr. |
Design of a gene delivery system to produce apoptosis of synovial fibriblasts. (Up to 2 Students) |
Designing and testing of adenoviral or other vectors to introduce Fas ligand in vivo to induce aopotosis and suppression of synovitis. RA tissue implanted ub SCID mice will be the initial mode. |
1 |
|
Dr. H.Ralph Schumacher,
Jr. |
Designing an improved biopsy needle and positioning techniques for synovial biopsy without need for arthroscopy (Up to 2 Students) |
Reviewing current techniques then developing and testing new devices and methods. |
1 |
|
Dr. Louis Soslowsky |
Orthopaedic Biomechanics Design Project. (Up to 2 Students) |
Design and optimization of components for a study of soft connective tissue functionality related to injury conditions. Integration of components into a protocol for tissue preparation, testing and processing. |
Joseph W. Smith Jennifer Friel |
|
Dr. Bernard
Steinberg |
Ultrasound disparity mapping. (1 Student) |
Ultrasound images from HUP are studied to examine the correlation properties at the lesion/tissue interface. Methods of correlation image processing and classification will be studied, including neural networks. Parameters which may be used as discriminants of benignand cancerous tissues will be identified. |
1 |
|
Dr. Bernard
Steinberg |
Precision Positioner (1 Student) |
A three dimensional positioner with 4micron accuracy will be put into operation. Control software will be developed. A series of tests will be designed and conducted to verify system performance and to perform controlled experiments in support of the ultrasound disparity mapping program. |
1 |
|
Dr. J.K. Udupa |
Joint contact area assessment via 3D imaging. (Up to 2 Students) |
Contact areas of skeletal joints are often determined by using pressure sensitive film in cadavers, we havedeveloped a new method which can be used in live subjects, involving 3dimaging via MRI. The project is to develop a way of comparing the 2 methods, and determining to what extent they give comparable results. |
1 |
|
Dr. J.K. Udupa |
Validation and clinical testing of a method of measuring brain tumor volume via MRI for assessing a therapy. (1 Student) |
Methods have been developed for identifying and delinerating brain tumors via MRI to make these procedure methods available in a clinical gene therapy trail. They have to be carefully validated to test what precision, accuracy and efficiency can be expected for them. |
1 |
|
Dr. J.K. Udupa |
3D Visualization of the soft and connective tissues of the foot via MRI. (1 Student) |
Description Not Available |
1 |
|
Joint Project: |
Design of a neural tissue
implants. (Up to 2 Students) |
Description Not Available |
1 |
Created: March
20, 2000
Last Update:
September 15, 2000
Updated By: Dan Pincus