Gel Electrophoresis: Elastin and Collagen’s Role in Functioning Arteries

Name: Karen Ryall

Class: BE 210

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This experiment’s objective is to compare the concentrations of extracellular matrix proteins in the arteries, specifically collagen and elastin. Changes in concentration of these two extracellular matrix proteins lead to arterial stiffening,³ which compromises the ability of the artery to deliver blood to the body. In this experiment I hypothesize that cardiac arteries will have a higher concentration of elastin than collagen. My hypothesis is based on elastin having more properties of resilience than collagen and previous experiments (4) demonstrating its affect on arterial health. This experiment will lead to increased knowledge on important proteins in the arteries and hopefully this knowledge can be incorporated in making more successful artery implants for bypass surgeries.