From: Subject: University of Pennsylvania : Research at Penn : Technology :: Understanding Cancer: Drug Efficacy and Development of the Oncosimulator Date: Thu, 25 Feb 2010 17:14:10 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01CAB63D.F1EEF4B0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CAB63D.F1EEF4B0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.upenn.edu/researchatpenn/article.php?1735&tch University of Pennsylvania : Research at Penn : = Technology :: Understanding Cancer: Drug Efficacy and Development of the = Oncosimulator =

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Lead Researcher Ravi = Radhakrishnan

Penn's Molecular Cell Engineering=20 Laboratory
  Home >=20 Technology=20 > Understanding Cancer: D...
Understanding Cancer: Drug Efficacy and = Development of=20 the Oncosimulator

February=20 12, 2010

By: University of Pennsylvania School of = Engineering=20 and Applied Science
Tumor=20 Complexity
=93It=92s like = looking for a=20 needle in a haystack,=94 says Ravi Radhakrishnan. =93We = don=92t even know=20 what we are looking for.=94 What he wants to know sounds = simple: why a=20 drug therapy for non-small cell lung cancer and glioblastoma = (cancer=20 of the brain) works in only about 5% of the population = receiving the=20 treatment. The 5%, however, share mutations in a protein = called the=20 epidermal growth factor receptor (EGFR). The majority of = patients=20 (95%) without the =93good=94 mutations do not respond to the = drug=20 treatment.

Subtle Difference, Profound = Effect
It=92s a=20 =93subtle difference,=94 says Radhakrishnan, assistant = professor of=20 bioengineering. =93Why does it have such a profound = effect?=94=20 Radhakrishnan has teamed up with cell biologist Mark Lemmon, = chair=20 of biochemistry and biophysics at Penn, and neuro-oncologist = Thomas=20 Deisboeck at Massachusetts General Hospital to find out. = =93Where,=94=20 Radhakrishnan wants to know, =93is the origin of = specificity?=94 Since=20 the drug ultimately targets a particular protein and the = cancer=20 manifests itself in an organ, where along the pathway from = drug to=20 molecule to cell to tissue to organ lies the=20 answer?

Radhakrishnan heads up the Molecular Systems = Biology=20 Laboratory. His research lies where chemical physics and = molecular=20 biology intersect. He calls himself a modeler. Taking the = wealth of=20 data on EGFR, he is probing the molecule-to-cell part of the = question computationally, while Lemmon performs the cell=20 experiments. Deisboeck does both the models and experiments = for the=20 tissue and organ (the tumor site). With all the possible = genetic and=20 epigenetic variations and the millions of proteins in our = cells that=20 also differ, it would be impossible to make sense of the = problem=20 without modeling, Radhakrishnan explains.

2020: The=20 Oncosimulator and the Center for Virtual Tumor
His model = will=20 also be a part of a larger project, led by Deisboeck, called = the=20 Center for Virtual Tumor. By 2020, the project members plan = to have=20 developed an oncosimulator that will be able to simulate the = microscopic progression of cancer cells. Without such a = tool, a=20 surgeon cannot intervene in many cancers before it is too = late=97for=20 the brain, a tumor the size of a millimeter is already too = large.=20 The collaborators hope that the oncosimulator will be used = for=20 clinical trials, eventually giving surgeons a better way to = know=20 when to intervene=97at cancer stages too early even to = detect=97before=20 it is too late. 		 
   
For=20 Additional Information Contact: Jordan Reese at=20 215-573-6604. 
   
 
 
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a=3D_uFixA(s,"&",_ust);=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= } else if (a>=3D0 && b>=3D0 && c>=3D0) {=0A= b =3D _uGC(dc,"__utmb=3D"+_udh,";");=0A= b =3D ("-" =3D=3D b) ? _udh : b; =0A= _ubd.cookie=3D"__utmb=3D"+b+"; path=3D"+_utcp+";"+x+_udo;=0A= } else {=0A= if (a>=3D0) a=3D_uFixA(_ubd.cookie,";",_ust);=0A= else {=0A= a=3D_udh+"."+_uu+"."+_ust+"."+_ust+"."+_ust+".1";=0A= nv=3D1;=0A= }=0A= _ubd.cookie=3D"__utma=3D"+a+"; path=3D"+_utcp+";"+nx+_udo;=0A= _ubd.cookie=3D"__utmb=3D"+_udh+"; path=3D"+_utcp+";"+x+_udo;=0A= _ubd.cookie=3D"__utmc=3D"+_udh+"; path=3D"+_utcp+";"+_udo;=0A= _ufns=3D1;=0A= }=0A= if (_ulink && xx && xx!=3D"" && xx!=3D"-") {=0A= xx=3D_uUES(xx);=0A= if (xx.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmx=3D"+xx+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= if (_ulink && v && v!=3D"" && v!=3D"-") {=0A= v=3D_uUES(v);=0A= if (v.indexOf(";")=3D=3D-1) _ubd.cookie=3D"__utmv=3D"+v+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= var wc=3Dwindow;=0A= var c=3D_ubd.cookie;=0A= if(wc && wc.gaGlobal && wc.gaGlobal.dh=3D=3D_udh){=0A= var g=3Dwc.gaGlobal;=0A= var ua=3Dc.split("__utma=3D"+_udh+".")[1].split(";")[0].split(".");=0A= if(g.sid)ua[3]=3Dg.sid;=0A= if(nv>0){=0A= ua[2]=3Dua[3];=0A= if(g.vid){=0A= var v=3Dg.vid.split(".");=0A= ua[0]=3Dv[0];=0A= ua[1]=3Dv[1];=0A= }=0A= }=0A= _ubd.cookie=3D"__utma=3D"+_udh+"."+ua.join(".")+"; = path=3D"+_utcp+";"+nx+_udo;=0A= }=0A= _uInfo(page);=0A= _ufns=3D0;=0A= _ufno=3D0;=0A= if (!page || page=3D=3D"") _uff=3D1;=0A= }=0A= function _uGH() {=0A= var hid;=0A= var wc=3Dwindow;=0A= if (wc && wc.gaGlobal && wc.gaGlobal.hid) {=0A= hid=3Dwc.gaGlobal.hid;=0A= } else {=0A= hid=3DMath.round(Math.random()*0x7fffffff);=0A= if (!wc.gaGlobal) wc.gaGlobal=3D{};=0A= wc.gaGlobal.hid=3Dhid;=0A= }=0A= return hid;=0A= }=0A= function _uInfo(page) {=0A= var 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