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The
rapid advancement in our understanding of the regulatory and signaling pathways
responsible for cell growth, differentiation, and death has led to the identification
of an array of anomalies in the genome and proteome that can be associated
with disease. Our laboratory is interested in developing molecular imaging
probes that target these anomalies to locate and study diseased states in
vivo. We are developing probes that target a wide range of biological processes
including gene regulation, mRNA localization, protein expression, and enzymatic
activity. Multiple imaging platforms are used including magnetic resonance,
fluorescence, and bioluminescence and applications range from studying the
complex intracellular dynamics of individual cells to the early detection
of disease in a clinical setting. |
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