Keith Neeves, Ph.D.
Institute for Medicine and Engineering
University of Pennsylvania
Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104
B.S. Chemical Engineering, University of Colorado at Boulder, 2000
Ph.D. Chemical and Biomolecular Engineering, Cornell University, 2006
The goal of this project is to understand how the generation of thrombin at the surface of platelets stabilizes blood clots. The primary roles of thrombin in clot formation are to catalyze fibrin polymerization and activate platelets. Which of these two mechanisms is most responsible for clot stability and under what flow conditions is unknown. To study clot stability, we use novel microfluidic methods for introducing soluble factors into flowing blood (Neeves & Diamond, Lab Chip, 8, 2008). By isolating the mechanism(s) that are responsible for clot stability at different flow conditions we expect to gain further insight into the pathology of bleeding disorders and embolism.