Hana Oh

Education

B.S. Chemical Engineering, Massachusetts Institute of Technology (MIT), 2005

Research Projects

Neutrophil adhesion and membrane mechanics under flow

Neutrophils are among the first cells to arrive on the site of inflammatory immune response. Selectins and their respective ligands mediate the initial recruitment and rolling process by promoting the interaction between circulating neutrophils and the vessel wall in vascular shear flow. I am studying the effect of pharmacological agents on the physical chemistry of adhesion molecules, which primarily control the adhesion, as well as cell deformability and morphology which influence adhesion dynamics. In particular, examining the effect of these agents on neutrophil tethering provides important insight to membrane fluidity as well as the strength of adhesion between the cell membrane and the underlying cytoskeleton. This pharmacomechanic study integrates pharmacology, neutrophil adhesion biology, and membrane biomechanics.

Publications

Oh H and Diamond SL. Ethanol Enhances Neutrophil Membrane Tether Growth and Slows Rolling on P-Selectin but Reduces Capture from Flow and Firm Arrest on IL-1-Treated Endothelium. The Journal of Immunology, 2008, 181: 2472-2482. [Journal page] [PDF]

Oh H, Siano B and Diamond SL. Neutrophil Isolation Protocol. Journal of Visualized Experiments, Issue 17, July 23, 2008. [Journal Page]