Jeremy Purvis

Institute for Medicine and Engineering
University of Pennsylvania
Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104
Tel: 215-573-6389
Email: purvis@mail.med.upenn.edu

Education

B.S., Microbiology & Cell Science, University of Florida, 2002

M.S. Microbiology & Cell Science, University of Florida, 2004

Advisors: Dr. Scott Diamond, Dr. Ravi Radhakrishnan

Research Projects

Using a combination of high-throughput experiments and computational modeling, I am investigating how genetically diverse platelets respond differentially to multiple external activators. Platelets play a pivotal role in responding to vascular injury and contribute to pathological conditions such as atherothrombosis and inflammation. In their resting state, they are smooth anucleate cell fragments containing an abundance of storage granules. When activated by binding to subendothelial tissue or excitatory agonists, platelets rapidly change shape and secrete the contents of their granules, recruiting additional platelets to the site of injury. To gain a quantitative understanding of activation signaling, we have developed a high-resolution, molecular systems model for the human platelet that is consistent with both resting and activated experimental data.

Website: http://purvislab.org

Website: http://bloodsystemsbiology.org