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Mechanobiology
Thrombolysis
Coagulation
Bioadhesion
Gene Therapy
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Proteomics
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Richard Li

Institute for Medicine and Engineering
University of Pennsylvania
Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104
Tel: 1 (215) 573-5704
Email: ruizhili@seas.upenn.edu

Education

M.S. Chemical and Biomolecular Engineering, University of Pennsylvania, 2013.
B.S. Chemical Engineering, Columbia University, 2011.

Research Projects

Detection of platelet sensitivity to antiplatelet therapies using a whole blood microfluidic assay.

Recapitulation of trauma and the fibrinolytic state under flow.

Microfluidic assay of hemophilic blood:  Studying contact pathway deficiencies.

Multiscale prediction of patient-specific platelet function under flow over tissue factor and collagen biomimetic surfaces

Research

I study the role of platelets in hemostasis and thrombosis in various microfluidic thrombosis models. Specifically, I examine the effects of various anti-platelet and anti-thrombotic therapies on platelet function under flow. I characterize platelet ligand-receptor dynamics, clot morphology, and the effects of antagonists on secondary platelet aggregation using in vitro  microfludic devices capable of recreating platelet biochemical signaling pathways and transport processes in vivo.     

 

 

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    Institute for Medicine & Engineering (IME)
    3340 Smith Walk
    1020 Vagelos Research Laboratories
    University of Pennsylvania
    Philadelphia, PA 19104-6383
    Lab No.: (215) 573-5704
    Fax: (215) 573-7227