Discher Lab -- Biophysical Eng'g. Labs:

in Molecular & Cell Biophysics  and  NanoBioPolymers

 

Invas'n-Mut'n Cancer: CurrBio 2017

Eng'd Macrophages engorge on Tumors:  Current Biology 2017 

Scar in a dish: Nature Materials 2015

Nano-Self:  Science 2013 

Nuc-StemCells-ECM: Science 2013

 

 

 

 

 

Welcome ! 

We are a diverse group of scientists & engineers with interests spanning molecular & cell biology and soft matter physics, including polymer nano-engineering. Students & Fellows pursue original research across these topic areas and many have progressed into positions in Academia and Industry (eg. Merck, Amgen, Genentech).  

Honors that reflect these many efforts include :

- elected Fellow of the American Academy for the Advancement of Science (2015)

- elected Member of the National Academy of Medicine (2015)

- elected Member of the National Academy of Engineering (2012)

We are the lead Lab in a new Cancer Physics Center, supported generously by a highly competitive 5-yr award from the NIH's NCI (Nat'l Cancer Inst.).

We focus on Differentiation, Stem Cells, & Cancer: Collagens-Cytoskeleton-Nucleus-Genome connections as well as 'Marker of Self', Phagocytosis and Cell Membrane dynamics.  Structures, interactions, and processes are studied in contexts ranging from short time scales (mechano-signaling, protein dynamics) to long time scales (expression, DNA repair, cell fates).

In Materials Biology & Drug/Gene Delivery, we develop and apply polymers in vivo as well as in vitro, from Block Copolymers for Self-Assembly/Nanoparticles (Polymersomes & Filomicelles) to Gels of Controlled MicroElasticity characterized by AFM among other physical tools. 

Methods & Materials constantly evolve in the Lab but vary from additional Nano/Micro physical tools and super-resolution fluroescence to recombinants & mutants, synthetic polymers & peptides, and molecular profiling.

A complete list of publications by number of citations.

A complete list of publications listed chronologically by year.

 

 

 

 

 

 

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discher 'at' seas dot upenn dot edu

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dennis.e.discher

Last Updated

2017-04-17