some covers
Click here for a complete publication list. [pubmed]
Stem Cell, Matrix, & Nuclear Biophysics
'Marker of Self' Immunobiology and Materials Biology
Molecular Mechanics and Proteomics
Assemblies -- Polymersomes and Filomicelles
some Stem Cell, Matrix, & Nuclear Biophysics
M. Raab, J. Swift, P.C.D.P. Dingal, P. Shah, J-W. Shin, and D.E. Discher. Crawling from Soft to Stiff Matrix polarizes the Cytoskeleton and phospho-regulates Myosin-II heavy chain. Journal of Cell Biology 199: 669-683 (2012).
J-W. Shin, J. Swift, K.R. Spinler, and D.E. Discher. Myosin-II inhibition and soft 2D matrix maximize multi-nucleation and cellular projections typical of platelet-producing megakaryocytes PNAS 108: 11458-11463 (2011).
A. Buxboim, I. Ivanova, and D.E. Discher. Matrix Elasticity, Cytoskeletal Forces, and Physics of the Nucleus: how deeply do cells ‘feel’ outside and in? Journal of Cell Science123: 297-308 (2010).
D.E. Discher, D.J. Mooney, P.W. Zandstra. Growth factors, matrices, and forces combine and control stem cells. Science 324:1673-1677 (2009) [pdf]
J.D. Pajerowski, K.N. Dahl, F.L. Zhong, P.J. Sammak, and D.E. Discher. Physical plasticity of the nucleus in stem cell differentiation. PNAS 104:15619-15624 (2007).[pdf]
A. Engler, S. Sen, H.L. Sweeney, D.E. Discher. Matrix elasticity directs stem cell lineage specification. Cell 126:677-689 (2006). [pdf]
D.E. Discher, P. Janmey, Y-L. Wang. Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139-1143 (2005). [pdf]
A. Engler, L. Bacakova, C. Newman, A. Hategan, M. Griffin, and D.E. Discher. Substrate compliance versus ligand density in cell on gel responses. Biophysical Journal 86:617-628 (2004). [pdf]
A. Engler, M. Griffin, S. Sen, C. Bonnemann, H.L. Sweeney, and D.E. Discher. Myotubes Differentiate Optimally on Substrates with Tissue-like Stiffness: Pathological Implications of Stiff or Soft Microenvironments. Journal of Cell Biology 166:877-887 (2004).[pdf]
some 'Marker of Self' Immunobiology & Materials Biology
P.L. Rodriguez, T. Harada, D.A. Christian, D.A. Pantano, R.K. Tsai, and D.E. Discher. Minimal 'Self' peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science 339: 971-975 (2013). [pdf]
F.Rehfeldt, A.E.X. Brown, M. Raab, S. Cai, A.L. Zajac, A. Zemel, and D.E. Discher. Hyaluronic Acid Matrices of Tunable Elasticity in 2D and 3D show Matrix Stiffness Dictates Cytoskeletal Order and Myosin-II phosphorylation within Stem Cells. Integrative Biology 4: 422-30 (2012).
A. Buxboim, K. Rajagopal, A.E.X. Brown, and D.E. Discher. How deeply cells feel: Methods for thin gels. Special Issue Journal of Physics: Condensed Matter 22: 194116 (2010).
R.K. Tsai and D.E. Discher. Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. Journal of Cell Biology 180:989-1003 (2008). [pdf] **Cover Article**
S. Subramanian, R. Parthasarthy, E. Boder, and D.E. Discher. Species- and cell-specific adhesive interactions between CD47 and human SIRPa. Blood 107:2548-2556 (2006). [pdf]
A. Engler, L. Bacakova, C. Newman, A.Popescu, M. Sheehan, and D.E. Discher. Substrate compliance versus ligand density in cell on gel responses. Biophysical Journal 86:617-628 (2004).[pdf]
some Molecular Mechanics and Proteomics
C.C. Krieger, X. An, H-Y. Tang, N. Mohandas, D.W. Speicher, & D.E. Discher. Cysteine Shotgun Mass Spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells. PNAS 108: 8269–8274 (2011).
C. Carag, N. Bhasin, M. Tewari, A.E.X. Brown, D. Safer, H.L. Sweeney, and D.E. Discher. Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: Mass Spectrometry mapping of most Exons and Cooperative Domain Designs based on Single Molecule Mechanics. Cytoskeleton 67:796–807 (2010).
A.E.X. Brown, R.I. Litvinov, D.E. Discher, P.K. Purohit, J.W. Weisel. Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water. Science 325:741-744 (2009).[pdf]
Colin P. Johnson, Hsin-Yao Tang, Christine Carag, David W. Speicher, and Dennis E. Discher. Forced Unfolding of Proteins Within Cells. Science 317:663-666 (2007).[pdf]
P. Dalhaimer, D.E. Discher, and T.C. Lubensky. Crosslinked actin networks show liquid crystal elastomer behaviour, including soft-mode elasticity. Nature Physics 96:354-360 (2007). [pdf]
S. Sen, S. Subramanian, and D.E. Discher. Indentation and adhesive probing of a cell membrane with AFM: model and experiments. Biophysical Journal 89:3203-3213 (2005). [pdf]
N. Bhasin, R. Law, G. Liao, D. Safer, J. Elmer, B.M. Discher, H.L. Sweeney, and D.E. Discher. Molecular extensibility of mini-dystrophins and a dystrophin rod construct. Journal of Molecular Biology 352:795-806 (2005). [pdf]
V. Ortiz, S. Nielsen, M.L. Klein, and D.E. Discher. Unfolding a linker between helical repeats. Journal of Molecular Biology 349:638-647 (2005). [pdf]
some Assemblies -- Polymersomes and Filomicelles
S.M. Loverde, M.L. Klein, D.E. Discher. Improved delivery of the anti-cancer drug Taxol by worm-like PEG-PCL micelles simulated by rational coarse grain molecular dynamics (rCG-MD). Advanced Materials 24: 3823-30 (2012).
D.A. Christian, A. Tian, W.G. Ellenbroek, I. Leventhal, K. Rajagopal, P.A. Janmey, A.J. Liu, T. Baumgart, D.E. Discher. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nature Materials 8:843-849 (2009). [pdf]
Yan Geng, Paul Dalhaimer, Shenshen Cai, Richard Tsai, Manorama Tewari, Tamara Minko, and Dennis E. Discher. Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology 2:249-255 (2007). [pdf]
F. Ahmed, R. Pakunlu, G. Srinivas, A. Brannon, F.S. Bates, M.L. Klein, T. Minko, and D.E. Discher. Shrinkage of a rapidly growing tumor by drug-loaded Polymersomes: pH-Triggered release through copolymer degradation. ACS - Molecular Pharmaceutics 3:340-350 (2006). [pdf]
F. Ahmed and D.E. Discher. Controlled release from polymersome vesicles blended with PEO-PLA or related hydrolysable copolymer. Journal of Controlled Release 96:37-53 (2004). [pdf] ** Best Paper Award 2004: Jorge Heller Award **
D.E. Discher and A. Eisenberg. Polymer Vesicles. Science 297:967-973 (2002). [pdf]