The overall goal of our laboratory is to understand the influence of mechanical factors on the structure and function of human tissues from the macroscopic to microscopic level, with an emphasis on the brain and lungs. This research is focused on opening avenues for injury prevention, therapeutic intervention, and good clinical management. The Injury Biomechanics Lab, under the direction of Dr. Susan Margulies, utilizes an integrated approach consisting of experiments to measure cell and tissue function/structure under carefully controlled loading conditions (deformations or forces), complemented by computational and translational models that extend these experimental findings to a broad range of real-world environments. Work in the laboratory has yielded fundamental information about the mechanical properties of the brain and skull, in vivo deformations of the brain and lung, and the cellular response to deformations which accompany lung inflation. Current work extends these studies to develop intervention and treatment strategies to reduce injury morbidity and improve outcomes.
Susan Margulies (l) and lab alumna Kristy Arbogast of the Children's Hospital of Philadelphia (r) were recently interviewed by WHYY's Newsworks:The Pulse to discuss protective equipment and sports concussions. (Elana Gordon/for The Pulse)
Susan Margulies' work as a member of the Committee on Sports-Related Concussions in Youth, within the Institute of Medicine and National Research Council, has culminated in the publication of Sports-Related Concussions in Youth: Improving the Science, Changing the Culture.
Lab members presented their work at the annual BMES conference in Seattle, WA.