Events

Matt Maltese's Dissertation Defense

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Congratulations to Matt Maltese for his hard work and dedication throughout his dissertation research! He gave an excellent presentation of his findings entitled, Traumatic Brain Injury Thresholds in the Pre-adolescent Juvenile, on May 3rd, 2012. Matt will continue to collaborate with the lab through his position in the Center for Child Injury Prevention Studies at the Children's Hospital of Philadelphia.

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2011 National Neurotrauma Society Symposium - Fort Lauderdale

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Several lab members attended the annual National Neurotrauma Symposium this year and presented the following posters of their research:

• Aggressive Cerebral Perfusion Pressure Augmentation with Phenylephrine Early After Traumatic Brain Injury Reduces Secondary Injury in a Pediatric Swine Model.
  Stuart Friess, Colin Smith, Todd Kilbaugh, Jill Ralston, Mark Helfaer, and Susan Margulies
• Ocular and Neuropathology from Cyclic, Low Velocity Head Rotations in Immature Pigs.
  Brittany Coats, Gil Binenbaum, Robert Peiffer, Sarah Sullivan, Jill Ralston, Trupti Akella, Colin Smith, Ann-Christine Duhaime, and Susan Margulies

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2011 Summer Lab Party--At the Beach!

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Thanks to Susan and Ken Margulies for hosting us at the beach for this summer's lab party. A fantastic time was had by one and all.

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Injury Biomechanics Lab Featured in Penn Engineering Magazine

Check out the Margulies' lab feature in the Penn Engineering Magazine

Engineering Delivers the Advantages in Protecting Children

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Brian DiPaolo's Dissertation Defense

Congratulations to Brian DiPaolo on an impressive presentation of his research, RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells, on November 3rd, 2010! Brian will be staying with the lab as a post-doctoral researcher.

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Lung Group Presents at BMES 2010

Lung Group member, Brian DiPaolo, gave a presentation of his work at the 2010 BMES Conference entitled High Magnitude Stretch Decreases MLC Phosphorylation in Alveolar Epithelia.


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Brittany Coats' Going Away Party

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Best of luck to lab alumna Brittany Coats as she moves on to a faculty position in Mechanical Engineering at the University of Utah! Check out her new lab website.


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Lab Members Present Posters at Neurotrauma 2010 - Las Vegas

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Drs. Stu Friess, Todd Kilbaugh, and Brittany Coats presented the following posters of their work at Neurotrauma 2010 in Las Vegas:

• Brain Tissue Oxygenation and Lactate-Pyruvate Ratio Correlate with Neuropathology after Pediatric Traumatic Brain Injury.
  Stuart Friess, Jill Ralston, Colin Smith, and Susan Margulies
• Cyclosporin A Improves Neuropathology and Neuro-Metabolic Recovery in an Immature Large Animal Translational Model of Diffuse Traumatic Brain Injury.
  Todd Kilbaugh, et. al.
• Development of a Finite Element Model for Predicting Subdural Hemorrhage from Rapid, Non-Impact Head Rotations.
  Brittany Coats, Sarah Sullivan, and Susan Margulies

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New Graduate Students Join the Head Injury Group

The lab would like to welcome Stephanie Pasquesi and Dianne Weeks to the head injury group.

Stephanie comes to the lab from the University of Illinois at Urbana-Champaign where she studied mechanical engineering but became interested in bioengineering. She is excited about pursuing areas of research at the intersection of mechanical and bioengineering, like testing the material properties of cerebral bridging veins and investigating the biomechanics of cyclic head injuries in children.

Dianne comes to the lab from the University of Maryland Baltimore County where she also studied mechanical engineering. She is interested in looking at the time-course of biological changes immediately following head injury in infants and toddlers and perhaps adding some new imaging techniques to the lab repertoire to aid in this investigation.



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2010 Lab Party at Margulies' House

Thanks to Susan and Ken Margulies for hosting this fun event.


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Taylor Cohen's Dissertation Defense

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Congratulation to Taylor Cohen for successfully defending his dissertation, Mechanisms of Stretch-Induced Barrier Disruption, on November 20th, 2009! He will be continuing his research career with a post-doctoral fellowship at Columbia University.

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Susan Margulies named a Fellow of Biomedical Engineering Society

Read more about this achievement here.

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Lung Injury Group Presents Abstracts at BMES Conference

Members of the lung injury group attended and presented abstracts at this year's Biomedical Engineering Society Conference in Pittsburgh, Pennsylvania.

• Stretch Activated JNK Signaling Increases Epithelial Permeability by Down Regulation of Occludin.
  Cohen TS, Lawrence GG., Margulies SS
• Expression Pattern of MiRNA in Large Cyclic Stretch of Alveolar Epithelial Cells.
  Yerrapureddy AN, Yehya N, Tobias JW, and Margulies SS.
• High Magnitude Stretch Activates Cofilin Rapidly in Alveolar Epithelia.
  DiPaolo BC and Margulies SS.

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Nicole Ibrahim's Dissertation Defense

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Congratulations to lab member, Nicole Ibrahim, for successfully defended her dissertation, Head Injury Biomechanics in Toddlers: Integrated Clinical, Anthropomorphic Dummy, Animal and Finite Element Model Studies – Implications for Age-Dependence , on August 18th, 2009! We wish her well as she moves on to work at the FDA.

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American Thoracic Society Conference 2009

Members of the lung group presented their work at the 2009 annual American Thoracic Society Conference in San Diego, CA.

• Septic Preconditioning Alters Stretch Induced MAPk Activation in Isolated Rat Alveolar Epithelial Cells (RAEC).
  Cohen TS and Margulies SS.
• Gelsolin Treatment Reduces Morbidity with Sepsis.
  Cohen TS, Bucki R, Rosenberg B, Ciccarelli N, Janmey PA, Margulies SS.
• Cyclic stretch magnitude and duration affect rat alveolar Type I epithelial cell gene expression.
  Yerrapureddy AN, Tobias J and Margulies SS

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Stephanie Eucker's Dissertation Defense

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Lab member, Stephanie Eucker, successfully defended her dissertation, Effect of Head Rotation Direction on Closed Head Injury in Neonatal Piglets, on November 25th, 2008. Congratulations to her on this outstanding achievement!

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Neurotrauma 2008 - Orlando, Florida

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Lab Members presented posters and had fun at Disney during the National Neurotrauma Society Meeting in Orlando, Florida! The following posters were given:

• Temporal Changes in Brain Tissue Oxygen and Metabolism following Diffuse Traumatic Brain Injury in Piglets
  Friess S, Ralston J, Eucker SA, Helfaer M, and Margulies SS.
• Regional Cerebral Blood Flow Response Following Brian Injury Depends on Direction of Head Motion.
  Eucker SA, Friess S, Ralston J, and Margulies SS.
• Kinematics of the Infant and Toddler during Low Height Falls
  Ibrahim N, Coats B, and Margulies SS.

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Neurotrauma 2007 - Kansas City, Missouri

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Head injury group members and collaborators presented posters of their work at the National Neurotrauma Society Meeting in Kansas City. These abstracts of our work were given:

• Brain Injury following Repeated mild Nonimpact Inertial Head Injury in Piglets is Dependent on Inter-injury Interval
  Friess S, Ralston J, Owens K, Helfaer M, Smith C, and Margulies SS.
• Severity of Damage Following Inertial Brain Injury Depends on Direction of Head Rotation
  Eucker SA, Smith C, Friess S, Naim M, Ralston J, and SS Margulies
• Comparison of Beta-APP and NF68 in the assessment of white matter injury
  Smith C, Ralston J, Ibrahim N, Truong A, Friess S, and SS Margulies
• Accidental Head Injury Patterns in Young Children
  Ibrahim N, Christian C, and Margulies SS

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