Publications

Head Injury Publications

Lung Injury Publications

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Head Injury Publications

• Sullivan S, Friess SH, Ralston J, Smith C, Propert KJ, Rapp PE, Margulies SS. Behavioral deficits and axonal injury persistence following rotational head injury are direction dependent. J Neurotrauma. 2012 Dec 7.
• Friess SH, Smith C, Kilbaugh TJ, Frangos SG, Ralston J, Helfaer MA, Margulies SS. Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model.Crit Care Med. 2012 Aug;40(8):2400-6.
• Coats B, Eucker SA, Sullivan S, Margulies SS. Finite element model predictions of intracranial hemorrhage from non-impact, rapid head rotations in the piglet. Int J Dev Neurosci. 2012 Jan 5.
• Friess SH, Naim MY, Kilbaugh TJ, Ralston J, Margulies SS. Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury. Lab Anim. 2012 Jan 11.
• Ibrahim NG, Wood J, Margulies SS, Christian CW. Influence of age and fall type on head injuries in infants and toddlers. Int J Dev Neurosci. 2011 Oct 31.
• Friess SH, Ralston J, Eucker SA, Helfaer MA, Smith C, Margulies SS. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011 Nov;69(5):1139-47.
• Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosproin A Preserves Mitochondrial Function after Traumatic Brain Injury in the Immature Rat and Piglet. J Neurotrauma. 2011 May;28(5):763-74.
• Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS.Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011 Jan;227(1):79-88.
• Naim MY, Friess S, Smith C, Ralston J, Ryall K, Helfaer MA, Margulies SS. Folic Acid Enhances Early Functional Recovery in a Piglet Model of Pediatric Head Injury. Dev Neurosci. 2010;32(5-6):466-79.
• Ibrahim NG and Margulies SS.  Biomechanics of the Toddler Head During Low Height Falls: An Anthropomorphic Dummy Analysis.  J Neurosurgery-Pediatrics. 2010 Jul;6(1):57-68. Featured Paper.
• Ibrahim NG, Ralston J, Smith C, and Margulies SS.  Physiological and Pathological Responses to Head Rotations in Toddler Piglets. J Neurotrauma 2010 Jun;27(6):1021-35.
• Coats B, Binenbaum G, Peiffer RL, Forbes B, Margulies SS.  Ocular Hemorrhages in Neonatal Porcine Eyes from Single, Rapid Rotational Events. Invest Ophthalmol Vis Sci. 2010 Apr 30.
• Eucker SA, Hofman BD, Natesh R, Ralston J, Armstead WM and Margulies SS. Development Of A Fluorescent Microsphere Technique For Rapid Histological Determination of Cerebral Blood Flow. Brain Research. 2010 Apr 22;1326:128-34.
• Ibrahim, NG, Natesh R, Szczesny SE, Ryall K, Eucker SA, Coats B, and Margulies SS. In Situ Deformations in the Immature Brain During Rapid Rotations.  J Biomech Eng. 2010 Apr;132(4):044501
• Margulies SS, Coats B, Christian C, Forbes B, Duhaime AC.  What Can We Learn from Computational Model Studies of the Eye? Invited Commentary. J AAPOS 2009, 13(4):332.
• Zhou C, Eucker S, Durduran T, Yu G, Ralston J, Friess, SH, Ichord RN, Margulies SS and Yodh AG.  Diffuse Optical Monitoring of Hemodynamic Changes in Piglet Brain with Closed Head Injury. J Biomed Optics 2009: 14(3): 034015 (June 4, 2009).
• Friess SH, Ichord R, Owens K, Ralston J, Ryall K, Helfaer M, Smith C, and Margulies SS. Repeated traumatic brain injury affects composite cognitive function in piglets. Journal of Neurotrauma 2009: 26:1111-1121.
• Margulies SS, Hicks, R and the Combination Therapies for Traumatic Brain Injury Workshop Leaders. Combination Therapies for Traumatic Brain Injury – Prospective Considerations. J. Neurotrauma 2009: 26:925-939.
• Coats B and Margulies SS. Potential for Head Injuries in Infants from Low Height Falls. Journal of Neurosurgery - Pediatrics 2008 Nov, 2(5):321-30. (Selected for Editorial Comment and journal cover)
• Coats B, Ji S and Margulies SS. Parametric Study of Head Impact in the Infant. Stapp Car Crash Journal 2007: 51:1-16.
• Friess SH, Ichord R, Owens K, Ralston J, Overall K, Smith C, Helfaer M, and Margulies SS. Neurobehavioral Functional Deficits Following Closed Head Injury in the Neonatal Pig. Exper Neurol 2007: 204:234-243.
• Ichord R, Naim M, Pollack A, Ibrahim N, Christian C, and Margulies SS. Ischemic Injury Complicates Traumatic Brain Injury in Infants. J Neurotrauma (Invited) 2007: 24:106-118.
• Ji S and Margulies SS. In Vivo Pons Motion within the Skull J. Biomech 2007: 40:92-99.
• Ning X, Zhu Q, Lanir Y, and Margulies SS. A Transversely Isotropic Viscoelastic Constitutive Model for Brainstem Undergoing Finite Deformation. J Biomech Eng. 2006 128(6):925-33.
• Coats BS and Margulies SS. Material Properties of Human Infant Skull and Suture at High Rates. J Neurotrauma 2006: 23(8):1222-1232.
• Levchakov A, Linder-Ganz E, Raghupathi R, Margulies SS, and A Gefen Computational Studies of Strain Exposures in Neonate and Mature Rat Brain During Cortical Impact J Neurotrauma 2006:1570-1580.
• Zhu Q, Prange M., Margulies SS. Predicting Unconsciousness From a Pediatric Brain Injury Threshold. Developmental. Neurosci (Invited) 2006:28:388-395.
• Margulies SS, Prange M, Myers B, Maltese MR, Ji S, Ning, X, Fisher J, Arbogast K, Christian C. Shaken Baby Syndrome: A Flawed Biomechanical Analysis. Letter to the Editor, Forensic Science International 2006: 164:278-279.
• Coats BS and Margulies SS. Material Properties of Porcine Parietal Cortex. J Biomech 2006:39: 2521-2525.
• Arbogast KB, Margulies SS and Christian CW. Initial Neurological Presentation in Young Children Sustaining Inflicted and Unintentional Fatal Head Injuries. Pediatrics 2005; 116: 180-184.
• Ji S, Dougherty L, Margulies SS. In vivo measurements of human brain displacement. Proc of 48th Stapp Car Crash Conference, SAE, 2004.
• Gefen A and Margulies SS. Are in vivo and in situ brain tissues mechanically similar? Journal of Biomechanics, 37:1339-1352, 2004.
• Raghupathi, R, Mehr MF, Helfaer MA, and Margulies SS. Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pig. Journal of Neurotrauma, 21:307-316, 2004.
• Gefen A, Gefen N, Zhu Q, Raghupathi R, and Marguiles SS. Age-Dependent changes in material properties of the brain and braincase of the rat. Journal of Neurotrauma, 20:1163-1177, 2003.
• Prange MT, Coats B, Duhaime AC, Margulies SS. Anthropomorphic simulations of falls, shakes, and inflicted impacts for infants. Journal of Neurosurgery, 99:143-150, 2003.
• Coats B and Margulies SS. Characterization of pediatric porcine skull properties during impact. Int Conf of Biomech of Impact, 57-66, 2003.
• Raghupathi, R and Margulies SS. Traumatic axonal injury following closed head injury in the neonatal pig. Journal of Neurotrauma, 19:843-853, 2002.
• Prange MT and Margulies SS. Regional, directional and age-dependent properties of brain undergoing large deformation. Journal of Biomechanical Engineering, 124:244-252, 2002.
• Meaney DF, Margulies SS, Smith DH. "Diffuse axonal injury." [Letter] Journal of Neurosurgery, 95(6):1108-10, 2001.
• Duhaime AC, Margulies SS, Durham SR, O'Rourke MM, Golden JA, Marwaha S, Raghupathi R. Maturation-dependent response of the piglet brain to scaled cortical impact. Journal of Neurosurgery, 93(3):455-462, 2000.
• Margulies SS and Thibault KL. Infant skull and suture properties: measurements and implications for mechanisms of pediatric brain injury. Journal of Bioimechanical Engineering, 122:364-371, 2000.
• Morrison B, Meaney DF, Margulies SS, McIntosh TK. Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters. Journal of Biomechanical Engineering, 122:224-230, 2000.(Winner of the 2001 American Society of Mechanical Engineers Richard Skalak Best Paper Award)
• Prange MT, Meaney DF, Margulies SS. Defining brain mechanical properties: effects of region, direction, and species. 44th Stapp Car Crash Conference, 2000.
• Arbogast KB and Margulies SS. A fiber-reinforced composite model of the viscoelastic behavior material characterization of the brainstem in shear. Journal of Biomechanics, 32(8):865-70, 1999 Aug
• Prange MT, Kiralyfalvi G, Margulies SS. Pediatric Rotational Inertial Brain Injury: The Relative Influence of Brain Size and Material Properties. Proc of 43rd Stapp Car Crash Conf, SAE, 1999 p 333-341. (Stapp Award Recipient)
• Margulies SS, Meaney DF, Smith D, Chen X-H, Miller R, Raghupathi R. A comparison of diffuse brain injury in the newborn and adult pig. Int. Comm for Biokinetics of Impact, 1999.
• Thibault KL and Margulies SS. Age Dependent Material Properties of Porcine Cerebrum: Effect on Pediatric Inertial Head Injury Criteria. Journal of Biomechanics, 31:1119-1126, 1998.
• Arbogast KB and Margulies SS. Material characterization of the brainstem from shear oscillatory tests. Journal of Biomechanics. 1998; 31(9):801-7.
• Miller RT, Margulies SS, Leoni M, Nonaka M, Chen X, Smith DH, and Meaney DF. Finite element modeling approaches for predicting experimental brain injury in an experimental model of severe diffuse axonal head injury: Proc of 42nd Stapp Car Crash Conf, SAE, 1998. (Stapp Award Recipient)
• Margulies SS, Yuan, Guccione SJ, Weiss MS. Kinematic response of the neck to voluntary and involuntary flexion. J Aviation Sp Environ Med 1998, 69(9):896-903.
• Yuan Q. Dougherty L. and Margulies SS. In vivo cervical spinal cord deformation and displacement in flexion. Spine 1998; 23(15): 1677-1683.
• Arbogast KB, Thibault KL, Pinheiro BS, Winey KI, and Margulies SS. A High-Frequency Shear Device For Testing Soft Biological Tissues. Journal of Biomechanics, Vol 30(7):757-759, 1997.
• Arbogast K and Margulies SS. Regional differences in mechanical properties of the central nervous system: Proc of 41st Stapp Car Crash Conf, SAE, 1997 p 293-300. Also published in SAE Tranasactions, 1997, Paper #973336.
• Yuan Q., Dougherty L, and Margulies SS.  In Vivo Spinal Cord Deformation in Flexion, Proc. SPIE Conference, International Society for Optical Engineering, Newport Beach, CA., 1997 (invited).
• Arbogast KB, Prange MT, Meaney DF., and Margulies S. Properties of Cerebral Gray and White Matter Undergoing Large Deformation.  Prevention Through Biomechanics Symposium Proceedings, 1997 (invited).
• Thibault KL and Margulis SS. Material properties of the developing porcine brain. Int. Comm for Biokinetics of Impact. 75-85, 1996.
• Thibault K, Radin A, and Margulies S.  Age-Dependent Properties of Porcine Skull.  Prevention Through Biomechanics Symposium Proceedings, 1996:3-10 (invited).
• Duhaime AC, Epplely M, Margulies SS, Heher KL, Bartlett SP. Crush injuries to the head in children. Neurosurgery, 37:401-407, 1995.
• Margulies SS and Thibault LE. A proposed tolerance criteriaon for diffuse axonal injury in man. Journal of Biomechanics, 25:7-23, 1992.
• Margulies SS, Thibault LE, and Gennarelli TA. Physical model simulations of brain injury in the primate. Journal of Biomechanics, 23:832-836, 1990.
• Thibault LE, Gennarelli TA, Margulies SS, Marcus JM, Eppinger R. The strain dependent pathophysiological consequences of inertial loading on central nervous system tissue. Proc Int Res Council on Biokinetics of Impact 1990.
• Margulies SS and Thibault LE. An analytical model of traumatic diffuse brain injury. Journal of Biomechanial Engineering, 111:241-49, 1989.
• Duhaime AC, Gennarelli TA, Thibault LE, Bruce DA, Margulies SS, Wiser R. The shaken baby syndrome - a clinical, pathological, and biomechanical study. Journal of Neurosurgery, 66:409-15, 1987.
• Thibault LE, Margulies SS, Gennarelli TA. The temporal and spatial deformation response of a brain model in inertial loading. Proc of 31st Stapp Car Crash Conf, SAE, 1987, p 267-272.
• Margulies SS, Thibault LE, Gennarelli TA. A study of scaling and head injury using physical model experiments. Proc Int Res Council on Biokinetics of Impacts, 1985, p 223-234.

Book Chapters

• Margulies SS and Coats B. Biomechanics of pediatric TBI. In V. Anderson & K. Yeates (Eds), Pediatric Traumatic Brain Injury: New Frontiers in Clinical and Translational Research. New York: Cambridge University Press. (2010)
• Margulies SS. and Coats B. “Biomechanics of Head Trauma in Infants and Young Children” in Child Abuse and Neglect: Diagnosis, Treatment and Evidence. Dr. Carol Jenny Ed. Elsevier Press (in press) 2009.
• Coats B and Margulies SS. Material properties of the pediatric head (Chapter 5) in Pediatric Injury Biomechanics. National Highway Traffic Safety Administration (In Press) 2009.
• Arbogast KB, Margulies SS, Patlak M, Fenner H, Thomas DJ. “Head and Neck Injury: Implications for Helmet Standards” Summary of a conference held at The Children’s Hospital of Philadelphia, Philadelphia, PA on March 31, 2003. Published by Snell Memorial Foundation.
• Margulies SS and Spivack BS. “Pathobiology and Biomechanics of Inflicted Childhood Neurotrauma” in Inflicted Childhood Neurotrauma, American Academy of Pediatrics, 2003. RM Reece and CE Nicholson eds. pp. 221-236.
• Laurer HL, Meaney DF, Margulies SS and McIntosh TK, “Modeling Brain Injury/Trauma” in Encyclopedia of the Human Brain, Vol 4, Academic Press, Elsevier Science and Technology Books, Ramachandran, VS, Editor.
• Margulies SS and Meaney DF, "Physical Characteristics of Human Brain Tissue" in Handbook of Biomaterials Properties , Chapman and Hall, J Black and G Hastings eds., pp.70-80.

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Lung Injury Publications

• Davidovich N, Huang J, Margulies SS. Reproducible uniform equibiaxial stretch of precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2013 Feb;304(4):L210-20.
• Cohen TS, DiPaolo BC, Lawrence GG, Margulies SS. Sepsis enhances epithelial permeability with stretch in an actin dependent manner. PLoS One. 2012;7(6)
• Yehya N, Yerrapureddy A, Tobias J, Margulies SS. MicroRNA modulate alveolar epithelial response to cyclic stretch. BMC Genomics. 2012 Apr 26;13:154.
• Dipaolo BC, Margulies SS. Rho kinase signaling pathways during stretch in primary alveolar epithelia. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 27.
• Mitchell LA, Overgaard CE, Ward C, Margulies SS, Koval M. Differential Effects of Claudin-3 and Claudin-4 on Alveolar Epithelial Barrier Function. Am J Physiol Lung Cell Mol Physiol. 2011 Apr 22.
• Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, Dinubile MJ, Janmey PA, Margulies SS. Therapeutic Potential of Plasma Gelsolin Administration in a Rat Model of Sepsis. Cytokine. 2011 Jun;54(3):235-8.
• DiPaolo BC, Lenormand G, Fredberg JJ, Margulies SS. Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia. Am J Physiol Cell Physiol. 2010 Aug;299(2):C345-53.
• Cohen TS, Gray Lawrence G, Margulies SS. Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung. PLoS One. 2010 Jun 25;5(6):e11322.
• Cohen TS, Gray Lawrence G, Khasgiwala A, Margulies SS. MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretch. PLoS One. 2010 Apr 28;5(4):e10385.
• Foster CD, Varghese LS, Gonzales LW, Margulies SS and Guttentag SH.  The Rho Pathway Mediates Transition to an Alveolar Type I Phenotype during Static Stretch of Alveolar Type II Cells.  Ped Research 2010 Jun;67(6):585-90.
• Yerrapureddy A, Tobias J, and Margulies SS.  Cyclic Stretch Magnitude and Duration Affect Rat Alveolar Epithelial Gene Expression. Cell Physiol Biochem 2010, 25:113-122.
• Cohen TS, Cavanaugh KJ and Margulies SS. Frequency and Peak Stretch Magnitude Affect Alveolar Epithelial Permeability. Eur Resp J 2008 32(4):854-61.
• Van Driessche W, Kreindler JL, Malik AB, Margulies S, Lewis SA, and Kim KJ Interrelations/crosstalk Between Transcellular Transport Function and Paracellular Tight Junctional Properties in Lung Epithelial and Endothelial Barriers. AJP-Lung Cellular and Molecular Physiology 2007: 293(3):L520-4.
• Brennick MJ. Gefter WB. Margulies SS. Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in cats. Respiratory Physiology & Neurobiology. 2007: 156(2):154-64.
• Fisher JL and Margulies SS. Modeling the Effect of Stretch and Plasma Membrane Tension on Na+/K+-ATPase in Alveolar Epithelial Cells. Am J Physiol -Cell 2007:292:L40-L53.
• Levine G, Deutschman C, Helfaer M and Margulies SS. Sepsis Induced Lung Injury in Rats Increases Alveolar Epithelial Vulnerability to Stretch. Crit Care Med 2006:34: 1746-1751.
• Cavanaugh KJ, Cohen TS and Margulies SS. Stretch increases alveolar epithelial permeability to uncharged micromolecules. Am J Physiol-Cell 2006; 290:C1179-1188.
• Patel A, Reigada D, Mitchell CH, Bates SR, Margulies SS. Koval M. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol - Lung Cell Mol 2005: 287:L1266-L1273.
• Fisher JL, Levitan I, and Margulies SS. Plasma membrane surface increases with tonic stretch of alveolar epithelial cells. Am. J. Resp. Cell Mol Biol 2004:31:200-208.
• Levinson H, Liu W, Oswari J, Peled Z, Hsu M, Longaker MT, Margulies SS. "Extracellular matrix and seeding density affect cell response to mechanical strain." Journal of Burns. Volume 1, 2002.
• Cavanaugh KJ and Margulies SS. Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method. Am J Physiol - Cell Physiol, 283:C1801-C1808, 2002.
• Fisher JL and Margulies SS. Na(+)-K(+)-ATPase activity in alveolar epithelial cells increases with cyclic stretch. J. Applied Physiology, 283:L737-L746, 2002.
• Cavanaugh KJ, Oswari J, Margulies SS. Role of stretch on tight junction structure in alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 25:584-591, 2001, Nov.
• Oswari J, Matthay MA, Margulies SS. Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Am J Physiology, 281:L1068-L1077, 2001
• Tschumperlin DJ, Oswari J, Margulies SS. Deformation-induced injury of alveolar epithelial cells: effect of frequency, duration, and amplitude. Am J. Resp and Crit Care Med, 152:357-362, 2000.
• Tschumperlin DJ and Margulies SS. Alveolar Epithelial Surface Area - volume relationship in isolated rat lungs. Journal of Applied Physiology 86(6):2026-33, 1999 Jun.
• Brennick MJ, Ogivie MD, Margulies SS, Hiller L, Gefter WB and Pack AI. MRI study of regional variations of pharyngeal wall compliance in cats. Journal of Applied Physiology. 85(5):1884-97, 1998 Nov
• Tschumperlin DJ and Margulies SS. Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. American Journal of Physiology - Lung 275(6 Pt 1):L1173-83, 1998 Dec.
• Boriek AM, Rodarte JR, Margulies SS. The zone of apposition in the passive diaphragm of the dog. Journal of Applied Physiology, 81:1929-40, 1996.
• Hubmayr RD and Margulies SS. Regional ventilation in statically and dynamically hyperinflated dogs. Journal of Applied Physiology, 81:1815-21, 1996.
• Margulies SS, Lei GT, Farkas GA, Rodarte JR. Finite element anaysis of stress in the canine diaphragm. Journal of Applied Physiology, 76:2070-75, 1994.
• Hubmayr RD, Farkas GA, Tao H-Y, Sieck GC, Margulies SS. Diaphragm mechanics in dogs with unilateral emphysema. J Clin Invest 91:1598-1603, 1993.
• Hubmayr RD, Margulies SS. Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure. J Appl Physiol 73(4):1650-1654, 1992.
• Margulies SS, Schriner RW, Schroeder MA, Hubmayr RD. Static lung-lung interactions in unilateral emphysema. J Appl Physiol ,73(2):545-551, 1992.
• Margulies SS. Regional variation in canine diaphragm thickness. Journal of Applied Physiology, 70:2663-68, 1991.
• Sprung J, Deschamps C, Margulies SS, Hubmayr RD, Rodarte JR. Effect of body position on regional diaphragm function in dogs. J Appl Physiol, 69:2296-2302, 1990.
• Margulies SS, Farkas GA, Rodarte JR. Effects of body position and lung volume on in situ operating length of canine diaphragm. J Appl Physiol, 69:1702-1708, 1990.
• Liu S, Margulies SS, Wilson TA. Deformation of the dog lung in the chest wall. J Appl Physiol, 68:1979-1987, 1990.
• Margulies SS, Rodarte JR. Shape of the chest wall in the prone and supine anesthetized dog. J Appl Physiol, 68:1970-1978, 1990.
• Margulies SS, Rodarte JR, Hoffman EA. Geometry and kinematics of dog ribs. J Appl Physiol, 67:707-712, 1989.

 

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