Title : Research Assistant Professor

Department of Mechanical Engineering and Applied Mechanics
University of Pennsylvania
210 Towne Building
220 S. 33rd St.

Philadelphia, Pennsylvania 19104-6315, USA

Phone: 215-746-2848


Research interests :

  • Lab-on-a-chip for point-of-care diagnostics, food safety, environment monitoring and drug delivery
  • BioMEMS device
  • Biosensors and nanobiotechnology
  • Micro and nano manufacturing


Education :

  • Ph. D. in Physical Electronics (BioMEMS), Institute of Electronics, Chinese Academy of Sciences, 03/2005;
  • M. S. in Organic Chemistry, Yunnan University, 03/2002;
  • B. S. in Applied Chemistry, Yunnan University, 09/1999.


Employment history :


Awards & honors :

  • Nomination award of national excellent doctorate dissertation of China (2007)
  • Excellent doctoral dissertation award, Chinese Academy of Sciences (2006)
  • Excellent president scholarship, Chinese Academy of Sciences (2004)
  • Award for excellent graduate students, Yunnan University (2000)
  • Award for excellent graduate, Yunnan Province (1999)
  • Award of Wu Daguan education funds, Yunnan University (1997, 2001)
  • Award for excellent undergraduate student, Yunnan University (1996-1998)


Research fundings :

    1. Fabrication of integrated microfluidic chip based on MOEMS technology and its applications, National Natural Science Foundation of China (NSFC) (Grant No. 60501020), 2006.1-2008.12.
    PI: Changchun Liu
    2. A microfluidic sensor system for point of care testing (POCT), National High Technology Research and Development Program of China (863 Program) (Grant No. 2006AA04Z355), 2006.11-2009.12.
    PI: Changchun Liu

Publications (Selected) :

    1. Changchun Liu, Jason Thompson and Haim H. Bau, A membrane-based, high-efficiency, microfluidic debubbler, Lab Chip (Accepted)
    2. Changchun Liu, Eran Geva, Michael Mauk, Xianbo Qiu, William R. Abrams, Daniel Malamud and Haim H. Bau, An isothermal amplification reactor with an integrated isolation membrane for point-of-care detection of infectious diseases in oral fluids, Analyst, DOI:10.1039/C1AN00007A (in press)
    3. Changchun Liu, Michael G. Mauk and Haim H. Bau, An integrated loop-mediated isothermal amplification cassette with thermally actuated valves, Microfluidics and Nanofluidics (Accepted)
    4. Changchun Liu*, Dafu Cui and Hui Li, A hard-soft microfluidic-based biosensor flow cell for SPR imaging application, Biosensors and Bioelectronics, 2010 26(1): 255-61.
    *corresponding author
    5. Changchun Liu*, Rapid fabrication of three-dimensional microfluidic chip using natural lotus leaf template, Microfluidics and Nanofluidics, 2010, 9: 923–931.
    *corresponding author
    6. Changchun Liu, Michael G. Schrlau and Haim H. Bau, Single bead-based electrochemical biosensor, Biosensors and Bioelectronics, 2009, 25(4): 809-814.
    7. Changchun Liu, Xianbo Qiu, Serge Ongagna, Dafeng Chen, Zongyuan Chen, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau, A timer-actuated immunoassay cassette for detecting molecular markers in oral fluids, Lab on a Chip, 2009, 9(6): 768-776.
    8. Changchun Liu*, Dafu Cui and Xing Chen, Development of an integrated direct-contacting optical-fiber microchip with LED-induced fluorescence detection, Journal of chromatography A, 2007, 1170(1-2): 101-106
    *corresponding author
    9. Changchun Liu*, Dafu Cui, Haoyuan Cai, Xing Chen and Zhaoxin Geng, An rigid Poly(dimethyl siloxane) sandwich electrophoresis microchip based on thin-casting method, Electrophoresis, 2006, 27(14): 2917-2923
    *corresponding author
    10. Changchun Liu*, Dafu Cui, Haoyuan Cai, Bo Su, Haining Wang and Xing Chen, An Integrated PDMS Electrophoresis Microchip with LED Induced Fluorescence Detection, Rare Metal Materials and Engineering, 2006, 35: 315-318
    *corresponding author
    11. Changchun Liu* and Dafu Cui, Design and fabrication of poly(dimethylsiloxane) electrophoresis microchip with integrated electrodes, Microsystem Technologies, 2005, 11(12): 1262-1266
    *corresponding author
    12. Xianbo Qiu, Michael G. Mauk, Dafeng Chen, Changchun Liu and Haim H. Bau, A large volume, portable, real-time PCR reactor, Lab Chip, 2010, 10, 3170-3177
    13. Dafeng Chen, Michael Mauk, Xianbo Qiu, Changchun Liu, Jitae Kim, Sudhir Ramprasad, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L.A.M. Corstjens, and Haim H. Bau, An Integrated Microfluidic Cassette for Isolation, Amplification, and Detection of Nucleic Acids, Biomedical Microdevices, 2010, 12(4): 705-719
    14. Xianbo Qiu, Jason A. Thompson, Zongyuan Chen, Changchun Liu, Dafeng Chen, Sudhir Ramprasad, Michael Mauk, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L.A.M. Corstjens and Haim H. Bau, Finger-Actuated, Self-Contained Immunoassay Cassettes, Biomedical Microdevices, 2009, 11(6): 1175-1186
    15. Xing Chen, Da-fu Cui and Changchun Liu, On-line cell lysis and DNA extraction on a microfluidic biochip fabricated by microelectromechanical system technology, Electrophoresis, 2008, 29(9): 1844-1851
    16. Xing Chen, Da Fu Cui, ChangChun Liu and Hui Li, Microfluidic chip for blood cell separation and collection based on crossflow filtration, Sensors and Actuators B, 2008, 130: 216–221
    17. Xing Chen, Da-fu Cui, Chang-chun Liu, Hui Li and Jian Chen, Continuous flow microfluidic device for cell separation, cell lysis and DNA purification, Analytica Chimica Acta , 2007, 584(2): 237-243
    18. Xing Chen, Da-fu Cui, Chang-chun Liu, Hui Li, Microfabrication and characterization of porous channels for DNA purification, Journal of Micromechanics and Microengineering, 2007, 17(1): 68-75
    19. Xing Chen, Da-fu Cui and Changchun Liu, Fabrication of DNA purification microchip integrated with mesoporous matrix based on MEMS technology, Microsystem Technologies, 2007, 14(1): 51-57
    20. Fang Yin, Yun Yao, Chanchun Liu and Mengliang Wen, Developments in the analysis of fluoride 1997-1999, Fluoride, 2001, 34(2):114-125

Professional services
Referee for professional journals:

    1. Lab on a chip
    2. Electrophoresis
    3. Microfluidics and Nanofluidics
    4. Journal of Micromechanics and Microengineering
    5. Chemical Communications
    6. Analyst
    7. Journal of separation science
    8. Journal of the American Ceramics Society
    9. Nanotechnology

Proposal reviewer:

    1. National High Technology Research and Development Program of China (863 program)
    2. National Nature Science Foundation of China (NSFC)