Publication

A full list of my publications can be found in my Google Scholar
* Corresponding author

2017

  1. Jinzhao Song, Changchun Liu, Michael G. Mauk, Shelley C. Rankin, James B. Lok, Robert M. Greenberg, and Haim H. Bau, Two-stage isothermal enzymatic amplification for concurrent multiplex molecular detection, Clinical Chemistry, 2017, doi:10.1373/clinchem.2016.263665
  2. Michael Mauk, Jinzhao Song, Haim H. Bau, Robert Gross, Frederic D. Bushman, Ronald G. Collman and Changchun Liu*, Miniaturized Devices for Point of Care Molecular Detection of HIV, Lab on Chip, 2017,17, 382-394. (Invited Review Article)

2016

  1. Song, Jinzhao, Michael G. Mauk, Brent A. Hackett, Sara Cherry, Haim H. Bau, and Changchun Liu*, Instrument-Free Point-of-Care Molecular Detection of Zika Virus. Analytical Chemistry, 2016, 88: 7289-7294
  2. Changchun Liu*, Shih-Chuan Liao, Jinzhao Song, Michael G. Mauk, Xuanwen Li, Gaoxiang Wu, Dengteng Ge, Robert M. Greenberg, Shu Yang and Haim H. Bau, A High-Efficiency Superhydrophobic Plasma Separator, Lab on Chip, 2016, 16, 553-560.
  3. Shih-Chuan Liao, Jing Peng, Michael G. Mauk, Sita Awasthi, Jinzhao Song, Harvey Friedman, Haim H. Bau, and Changchun Liu*, Smart Cup: A Minimally-Instrumented, Smartphone-Based Point-of-Care Molecular Diagnostic Device, Sensors and Actuators B: Chemical, 2016, 229, 232-238.
  4. Michael G Mauk, Jinzhao Song, Yubing Tong, Haim H Bau and Changchun Liu*, Translating Nucleic Acid Amplification Assays to the Microscale: Lab on a Chip for Point-of-Care Molecular Diagnostics, Current Analytical Chemistry, 2016, 12, 386-396. (Invited Review Article)

2015

  1. Jinzhao Song, Changchun Liu, Swarna Bais, Michael G. Mauk, Haim H. Bau, and Robert M. Greenberg, Molecular detection of schistosome infections with a disposable microfluidic cassette, PLOS Neglected Tropical Diseases, 2015, 9(12): e0004318. doi:10.1371/journal.pntd.0004318.
  2. Michael G. Mauk, Changchun Liu, Jinzhao Song and Haim H. Bau,Integrated Microfluidic Nucleic Acid Isolation, Isothermal Amplification, and Amplicon Quantification, Microarrays, 2015, 4(4), 474-489.
  3. Karen E Ocwieja, Scott Sherrill-Mix, Changchun Liu, Jinzhao Song, Haim Bau, Frederic D Bushman, A Reverse Transcription Loop-Mediated Isothermal Amplification Assay Optimized to Detect Multiple HIV Subtypes, PLoS One, 2015, 10(2): e0117852

2014

  1. Changchun Liu*, Mohamed M. Sadik, Michael G. Mauk, Paul H. Edelstein, Frederic D. Bushman, Robert Gross and Haim H. Bau, Nuclemeter: A Reaction-Diffusion based Method for Quantifying Nucleic Acids Undergoing Enzymatic Amplification, Scientific Reports, 2014, 4: 7335, DOI: 10.1038/srep07335.

2013

  1. Changchun Liu*, Michael Mauk, Robert Gross, Frederic D. Bushman, Paul H. Edelstein, Ronald G. Collman, and Haim H. Bau, Membrane-Based, Sedimentation-Assisted Plasma Separator for Point-of-Care Applications, Analytical Chemistry, 2013, 85, 10463-10470.

2012

  1. Changchun Liu, Michael G. Mauk, Robert Hart, Mariangela Bonizzoni, Guiyun Yan and Haim H. Bau, A low-cost microfluidic chip for rapid genotyping of malaria-transmitting mosquitoes, PLoS ONE, 2012, 7(8): e42222.

2011

  1. Changchun Liu, , Michael Mauk, Robert W. Hart, Xianbo Qiu, and Haim H. Bau, A self-heating cartridge for molecular diagnostics, Lab Chip, 2011, 11, 2686-2692
  2. Changchun Liu, Jason Thompson and Haim H. Bau, A membrane-based, high-efficiency, microfluidic debubbler, Lab Chip, 2011, 11, 1688-1693
  3. Changchun Liu, Eran Geva, Michael Mauk, Xianbo Qiu, William R. Abrams, Daniel Malamud and Haim H. Bau, An isothermal amplification reactor with an integrated isolation membrane for point-of-care detection of infectious diseases in oral fluids, Analyst, 2011, 136, 2069-2076
  4. Changchun Liu, Michael G. Mauk and Haim H. Bau, An integrated loop-mediated isothermal amplification cassette with thermally actuated valves, Microfluidics and Nanofluidics, 2011, 11, 209-220
  5. Xianbo Qiu, Changchun Liu, Michael G. Mauk, Robert W. Hart, Dafeng Chen, Jing Qiu, Terry Kientz, Jonathan Fiene, and Haim H. Bau, A Portable Analyzer for Pouch-Actuated, Immunoassay Cassettes, Sensors and Actuators B, 2011, 160, 1529-1535.
  6. Xianbo Qiu, Dafeng Chen, Changchun Liu, Michael G. Mauk, Terry Kientz, and Haim H. Bau, An Analyzer for Microfluidic-Based Molecular Analysis, Biomedical Microdevices, 2011, 13, 809-817
  7. Robert W. Hart, Michael G. Mauk, Changchun Liu, Xianbo Qiu, Jason A. Thompson, Dafeng Chen, Daniel Malamud, William R. Abrams, and Haim H. Bau, Point of care oral-based diagnostics, Oral Diseases, 2011, 17, 745-752
  8. Michael G. Mauk, Changchun Liu, Daniel Malamud and Haim H. Bau, Streamlining point-of-care molecular diagnostics systems, IVD technology, December, 14, 2011 (http://www.ivdtechnology.com/article/streamlining-poc-microfluidic-molecular-diagnostics)

2010

  1. Changchun Liu*, Dafu Cui and Hui Li, A hard-soft microfluidic-based biosensor flow cell for SPR imaging application, Biosensors and Bioelectronics, 2010, 26(1): 255-261.
  2. Changchun Liu*, Rapid fabrication of three-dimensional microfluidic chip using natural lotus leaf template, Microfluidics and Nanofluidics, 2010, 9:923–931.
  3. Xianbo Qiu, Michael G. Mauk, Dafeng Chen, Changchun Liu and Haim H. Bau, A large volume, portable, real-time PCR reactor, Lab Chip, 2010, 10, 3170-3177
  4. Dafeng Chen, Michael Mauk, Xianbo Qiu, Changchun Liu, Jitae Kim, Sudhir Ramprasad, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L.A.M. Corstjens, and Haim H. Bau, An Integrated Microfluidic Cassette for Isolation, Amplification, and Detection of Nucleic Acids, Biomedical Microdevices, 2010, 12(4): 705-719

2009

  1. Changchun Liu, Michael G. Schrlau and Haim H. Bau, Single bead-based electrochemical biosensor, Biosensors and Bioelectronics, 2009, 25(4): 809-814
  2. Changchun Liu, Xianbo Qiu, Serge Ongagna, Dafeng Chen, Zongyuan Chen, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau, A timer-actuated immunoassay cassette for detecting molecular markers in oral fluids, Lab on a Chip, 2009, 9(6): 768-776
  3. Xianbo Qiu, Jason A. Thompson, Zongyuan Chen, Changchun Liu, Dafeng Chen, Sudhir Ramprasad, Michael Mauk, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L.A.M. Corstjens and Haim H. Bau, Finger-Actuated, Self-Contained Immunoassay Cassettes, Biomedical Microdevices, 2009, 11(6): 1175-1186

2008

  1. Xing Chen, Da-fu Cui and Chang-chun Liu, On-line cell lysis and DNA extraction on a microfluidic biochip fabricated by microelectromechanical system technology, Electrophoresis, 2008, 29(9): 1844-1851
  2. Xing Chen, Da Fu Cui, Chang Chun Liu and Hui Li, Microfluidic chip for blood cell separation and collection based on crossflow filtration, Sensors and Actuators B, 2008, 130: 216–221

2007

  1. Changchun Liu*,Dafu Cui and Xing Chen, Development of an integrated direct-contacting optical-fiber microchip with LED-induced fluorescence detection, Journal of chromatography A, 2007, 1170(1-2): 101-106.
  2. Xing Chen, Da-fu Cui, Chang-chun Liu, Hui Li, Microfabrication and characterization of porous channels for DNA purification, Journal of Micromechanics and Microengineering, 2007, 17(1): 68-75
  3. Xing Chen, Da-fu Cui, Chang-chun Liu, Hui Li and Jian Chen, Continuous flow microfluidic device for cell separation, cell lysis and DNA purification, Analytica Chimica Acta , 2007, 584(2): 237-243
  4. Xing Chen, Da-fu Cui and Chang-chun Liu, Fabrication of DNA purification microchip integrated with mesoporous matrix based on MEMS technology, Microsystem Technologies, 2007, 14(1): 51-57
  5. Xing Chen, Da-fu Cui, Chang-chun Liu, Hui Li and Weixing Zhao, Sample pretreatment microfluidic chip for DNA extraction from rat peripheral blood, Frontiers of Chemistry in China, 2007, 2(1): 74-78
  6. Yutai Li, Dafu Cui and Changchun Liu, MEMS-based microfabricated columns for gas chromatography, Micronanoelectronic Technology, 2007, 44 (7): 407-409, 416
  7. Dafu Cui, Jinqing Liang, Haoyuan Cai, Junbo Wang, Yating Li, Yujie Wang, Changchun Liu and Zipan Zheng, Research of image SPR biosensor and its multi microarray chip, Progress on Natural Science, 2007,17(1): 93-98
  8. Dafu Cui, Lulu Zhang, Yujie Wang, Hui Li and Changchun Liu, Research and Development of Surface Plasmon Resonance Biochemical Analysis Instrument, Modern Scientific Instruments, 2007, 2: 3-7
  9. Hui Li, Dafu Cui, Jinqing Liang, Changchun Liu, Yujie Wang and Haoyuan Cai, Imaging array SPR iosensor immunoassays for sulfamethoxazole and sulfamethazine, Chinese Journal of Sensors and Actuators, 2007, 20(7): 1479-1482
  10. Xing Chen, Dafu Cui, Changchun Liu, Hui Li and Zhaoxin Geng, Microfluidc cell separation chips based on crossflow filtration, Chemical Journal of Chinese University,2007, 28(1): 59-61

2006

  1. Changchun Liu*,Dafu Cui, Haoyuan Cai, Xing Chen and Zhaoxin Geng, An rigid Poly(dimethyl siloxane) sandwich electrophoresis microchip based on thin-casting method, Electrophoresis, 2006, 27(14): 2917-2923.
  2. Changchun Liu, Dafu Cui, Haoyuan Cai, Bo Su, Haining Wang and Xing Chen, An Integrated PDMS Electrophoresis Microchip with LED Induced Fluorescence Detection, Rare Metal Materials and Engineering, 2006, 35(suppl. 3): 315-318
  3. Xing Chen, Da-fu Cui, Chang-chun Liu, and Haoyuan Cai, Fabrication of Solid Phase Extraction DNA Chips Based on Bio-Micro-electron-Mechanical System Technology, Chinese Journal of Analytical Chemistry, 2006, 34(3): 433-437
  4. Xing Chen, Da-fu Cui and Chang-chun Liu, High Purity DNA Extraction with a SPE Microfluidic Chip Using KI as the Binding Salt, Chinese Chemical Letter, 2006, 17(8): 1101-1104
  5. Xing Chen, Da-fu Cui, Chang-chun Liu, Bo Su and Hai-ning Wang, High Performance DNA Purification Microchip with Porous Silicon Dioxide Carrier Matrix, Rare Metal Materials and Engineering, 2006, 35(suppl. 3) : 284-287
  6. Bo Su, Da-fu Cui, Chang-chun Liu and Hai-ning Wang, Fabrication of microfluidic fiber chip detection system, Rare Metal Materials and Engineering, 2006, 35(suppl. 3): 525-526
  7. Zhao-xin Geng, Da-fu Cui, Hai-ning Wang, Chang-chun Liu, Bo Su, A Novel Integrated PZT-Driven Micropump and Microvalve, Rare Metal Materials and Engineering, 2006, 35(suppl. 3): 540-542
  8. Bo Su, Da-fu Cui, Chang-chun Liu, Fabrication of microfluidic fiber chip detection system, Chinese Journal of Analytical Chemistry, 2006, 34(Suppl. 1): 295-298
  9. Zhaoxin Geng, Dafu Cui and Changchun Liu, Manufacture and Performance Comparison of Two Kinds of Self-Priming Micropump Driven by PZT, Nanotechnology and Precision Engineering, 2006, 4(4): 320-325
  10. Haining Wang, Da-fu Cui, Zhaoxing Geng, Chang-chun Liu and Xing Chen, A valveless piezoelectric micropump, Piezoelectrics & Acoustooptics, 2006, 28(6): 668-670
  11. Xing Chen, Dafu Cui, Changchun Liu and Li Wang, BioMEMS technology based sample pretreatment microfluidic chips, Micronanoelectronic Technology, 2006, 43(1): 43-46
  12. Xing Chen, Dafu Cui, Changchun Liu and Hui Li, Bio MEMS microfluidic chips for blood sample pretreatment, Chinese Journal of Sensors and Actuators, 2006, 19(5): 1991-1995
  13. Zhaoxin Geng, Dafu Cui, Haining Wang, Changchun Liu, Design of a novel piezoelectric micropump structure, Transducer and Microsystem Technologies, 2006, 25(12): 82-84, 88.
  14. Bo Su, Dafu Cui, Changchun Liu, Xing Cheng, and Jianhai Sun, Fabrication of PDMS Electrophoresis Chip With Fiber, Chinese Journal of Test and Measurement Technology, 2006, 20(5): 402-406
  15. Xing Chen, Da-fu Cui, Chang-chun Liu, and Haoyuan Cai, Fabrication of solid phase extraction deoxyrionucleic acid chips based on Bio-Micro-electron-Mechanical system Technology, Chinese Journal of Analytical Chemistry, 2006, 34(3): 433-436
  16. Xing Chen, Dafu Cui, Changchun Liu, and Haoyuan Cai, Microfluidic biochip for blood cell lysis, Chinese Journal of Analytical Chemistry, 2006, 34(11): 1656-1660
  17. Xing Chen, Dafu Cui, Changchun Liu, Hui Li and Weixing Zhao, Sample pretreatment microfluidic chip for DNA extraction from rat peripheral blood, Chemical Journal of Chinese University, 2006, 27(4): 618-621

2005

  1. Changchun Liu* and Dafu Cui, Design and fabrication of poly(dimethylsiloxane) electrophoresis microchip with integrated electrodes, Microsystem Technologies, 2005, 11(12): 1262-1266
  2. Bo Su, Da-fu Cui, Changchun Liu, Xing Chen and Haining Wang, Fabrication Technology of PDMS Microfluidic Fiber Chip, Chinese Journal of Microfabrication Technology, 2005, 79(3): 57-61
  3. Qiang Zhao, Da-fu Cui, Li Wang, Haining Wang and Changchun Liu, The study on the dynamic characteristic of the valveless piezoelectric micropump, Piezoelectrics & Acoustooptics, 2005, 27(6): 631-633
  4. Xing Chen, Da-fu Cui, Changchun Liu, Bo Su and Haining Wang, Sample Pretreatment Biochip Based on Micro Electro Mechanical Systems, Instrument Technique and Sensor, 2005, 2: 1-3
  5. Bo Su, Dafu Cui, Changchun Liu, Xing Chen and Jianhai Sun, Fabrication of PDMS electrophoresis chip with fiber, Chinese Journal of Measure and control technology, 2005, 24(11): 5-8

2004

  1. Changchun Liu, Dafu Cui, Li Wang, Poly(dimethylsiloxane) based microchip for DNA electrophoresis, Progress in natural science, 2004, 14(7): 593-597
  2. Changchun Liu, Dafu Cui, Haoyuan Cai, Li Wang, Bo Su, Poly(dimethylsiloxane)-based sandwich microchip for DNA electrophoresis, Chemical Journal of Chinese Universities, 2004, 25(suppl. 4): 39-40
  3. Changchun Liu, Dafu Cui, Qiang Zhao, Li Wang, Lei Wang, Fabrication of PDMS electrophoresis microchip based on MEMS technology, Chinese Journal of Microfabrication Technology, 2004, 79(1): 58-61
  4. Changchun Liuand Dafu Cui, Fabrication technology of polydimethylsloxane microfluidic chip, Chinese Journal of Transducer Technology, 2004, 23(7): 77-80
  5. Dafu Cui and Changchun Liu, Novel characteristics of biochemical sensors in their development, Chinese Journal of Measure and control technology, 2004, 23(3): 1-4

2003

  1. Changchun Liu and Dafu Cui, Electrochemical sensor and its application in lab-on-a-chip, Chinese Journal of Transducer Technology, 2003, 22(7): 1-3, 6

2002

  1. Changchun Liu, Zhihua Liu, Yun Yao and Mengliang Wen, Ion-selective electrode for perthidine hydrochloride and its applications to pharmaceutical analysis, Chinese Journal of Analytical Science, 2002, 18(6): 475-477

2001

  1. Changchun Liu and Mengliang Wen, A brief description of biochip, Chinese Journal of Instrumental Analysis, 2001, 20(3): 13-16
  2. Fang Yin, Yun Yao, Chanchun Liu and Mengliang Wen, Developments in the analysis of fluoride 1997-1999, Fluoride, 2001, 34(2):114-125

Contact Details

Telephone: (215)-746-2848
Email: lchangc@seas.upenn.edu
Website: www.seas.upenn.edu/~lchangc

210 Towne Building
220 S. 33rd St.
Philadelphia,
Pennsylvania, 19104-6315, USA