People

 

 

 

Here is a picture of several lab members in Skirkanich Hall.

From left to right: (bottom row) Emory, Yung Chia, Dave (2nd row) Adam, Anthony (3rd row) Mahlet, Pallab (4th row) Rosie, Katie, Jennifer (top row) William

 

 

 

 

Principal Investigator

 

 

 

Dr. David F. Meaney

BSE in Biomedical Engineering- Rensselaer Polytechnic Institute, 1987

MSE, 1989 and Ph.D., 1991, in Bioengineering, the University of Pennsylvania

dmeaney@seas.upenn.edu

 

 

 

 

 

 

Post-Doctoral Fellows

 

 

 

Anthony Choo , Ph.D.

BASc in Engineering Science, University of Toronto, 1998

MASc in Mechanical Engineering, University of British Columbia, 2001

PhD in Mechanical Engineering, University of British Columbia, 2007


chooa@seas.upenn.edu

 

Research Interests:

Fibrin gels as a neuroprotective and growth permissive substrate for
repairing brain injuries

Two-photon in vivo imaging of mechanical injuries in the cortex

Patterns of mechanical injury in organotypic hippocampal slice cultures

Spinal cord injury and repair

Rosalind (Rosie) E. Mott, Ph.D.

BS Biomedical Engineering, Johns Hopkins University, 1999

Ph.D. Biomedical Engineering, University of Virginia, 2008

rmott@seas.upenn.edu

 

Research Interests:

The impact of injury on protein translation at the dendritic spine

The mechanisms of protein translation in synaptic plasticity

Biochemical coupling/crosstalk of dendritic spines

Live cell imaging

 

 

 

 

PhD Students

 

 

 

Yung Chia Chen

BSE in Biomedical Engineering, University of Maryland, Baltimore County

PhD student in Bioengineering

cheny@seas.upenn.edu

 

Research Interests: 

 

Changes in astrocytic signalling after neurotrauma through:

   - In vivo 2-photon imaging

   - Mechanical injury to hippocampal slice cultures

   - Mechanical injury to cell cultures

Mahlet N. Mesfin

BSE in Chemical Engineering, University of Michigan, 2003

MSE in Biomedical Engineering, University of Michigan, 2004

Ph.D. candidate in Bioengineering

mesfinm@seas.upenn.edu

 

Research Interests:


Examining the expression and activation of a tyrosine phosphatase following TBI

Determine how protein interactions can modulate signaling cascades after TBI

Determining if targetted disruption of certain protein interactions can affect neuronal fate after injury

Pallab Singh

BS in Biomedical Engineering, University of Rochester, 2004

Ph.D. Candidate in Bioengineering

psingh@seas.upenn.edu

 

Research Interests:

 

The response of specific NMDA Receptor subtypes to mechanical injury

The development of a computational model to investigate the patterns of glutamate receptor activation and the resulting intercellular signaling under physiological and pathological conditions

Jennifer Spaethling

BS in Chemical Engineering, Bucknell University, 2003

Ph.D. Candidate in Pharmacology

jspaethl@mail.med.upenn.edu

 

Research Interests:

Signaling pathways leading to insertion of calcium permeable AMPA receptors at the synapse

Contribution of calcium permeable AMPA receptors to neuronal fate following TBI

Possible therapies targeted to the calcium permeable AMPA receptor population following TBI

Katie von Reyn

BS in Mechanical Engineering, Georgia Tech 2003

Ph.D. Candidate in Bioengineering

vonreyn@seas.upenn.edu

 

Research Interests:

My research focuses on the role of the voltage gated sodium channel (NaCh) in traumatic brain injury (TBI), specifically by:

- Identifying changes in NaCh structure, function, and expression following a TBI

- Investigating the mechanisms that mediate these changes

- Determining how these changes direct overall outcome following a TBI

 

 

 

 

Masters Students

 

 

 

William Hong

BSE in Biomedical Engineering, Duke University, 2005

Master's student in Biotechnology

whong@seas.upenn.edu

 

Research Interests:

Neurodegeneration in post-traumatic brain injury

 

 

 

 

Research Technicians

 

 

 

Adam Hockenberry

BA in Biological Anthropology, Temple University 2008

adamhock@seas.upenn.edu

 

Research Interests:

Neuronal cell culture

Analyze how varying states of cellular actin affect the movement of mitochondria in neuronal processes

Determine the possible role that this could have for the energy supply to active areas of the neuron

 

Emory Kuo

BE in Biomedical Engineering, SUNY at Stony Brook, 2008

kuor@seas.upenn.edu

 

Research Interests:

Perform animal models of brain injury using surgical techniques and mechanical devices

Study protein marker and its protein expression after TBI

Study astrocyte response and calcium influx after injury

Breed transgenic mice

 

 

 

 

Undergraduates

 

 

 

Minna Zhang

Bioengineering student, C/O 2010

zhangml@seas.upenn.edu

 

 

 

 

 

 

Lab Alumni

 

 

 

Bill Miller, Ph.D .

 

 

 

Donna M. Geddes-Klein, Ph.D.

 

 

Michael DeRidder, Ph.D.

 

 

Andrew Taylor, MD, Ph.D.

 

 

 

Allison Bain, Ph.D.

 

 

Theresa Lusardi, Ph.D.

 

 

Reid Miller, Ph.D.

 

 

David Shreiber, Ph.D.

 

 


Dave Scarsella, BS, MS

Gang Liu, MD

Gul Serbest, PhD

Kimberly Schiffman, BS

Evan Silverstein, BSE

Melissa Simon, BSE

Adam Sinensky, BSE

Krithika Ramamoorthy, MSE

Jeff Rangan, BSE

Jessica Barag, BSE

Dora Chiang, BSE

Jeff Gross, BSE

Josh Kachner, BSE

Michael Kohanski, BSE

Jimmy Sastra, BSE

Justin Tannir, BSE

Tracy Yuen, BSE

Ashley Grosvenor, BA