Research Expertise: Tissue Engineering | Orthopaedic Bioengineering | Biomaterials
Rob's research program focuses on the engineering of musculoskeletal tissues, with a particular focus on articular cartilage, the knee meniscus, and the intervertebral disc. His group uses rigorous mechanical and molecular analyses to understand the emerging functional properties of engineered tissues, to precisely define the criteria and routes toward 'success' from native tissue structure and function, and to focus technology development on improving these critical features in engineered constructs. Specifically, this work employs adult mesenchymal stem cells, custom mechanobiologic culture conditions, and novel scaffolding technologies to enhance and direct functional tissue development.
PhD Biomedical Engineering 2003 - Columbia University
- Cell migration: implications for repair and regeneration in joint disease, Qu, F. | Guilak, F. | Mauck, R.L., Nature Reviews Rheumatology, 2019
- Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures, Kim, M. | Steinberg, D.R. | Burdick, J.A. | Mauck, R.L., Proceedings of the National Academy of Sciences of the United States of America, 2019
- Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity, Patel, J.M. | Saleh, K.S. | Burdick, J.A. | Mauck, R.L., Acta Biomaterialia, 2019
- Mechanically Activated Microcapsules for “On-Demand” Drug Delivery in Dynamically Loaded Musculoskeletal Tissues, Mohanraj, B. | Duan, G. | Peredo, A. | Kim, M. | Tu, F. | Lee, D. | Dodge, G.R. | Mauck, R.L., Advanced Functional Materials, 2019
- ACVR1 R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification, Haupt, J. | Stanley, A. | McLeod, C.M. | Cosgrove, B.D. | Culbert, A.L. | Wang, L. | Mourkioti, F. | Mauck, R.L. | Shore, E.M., Molecular Biology of the Cell, 2019