Research Expertise: Tissue Engineering | Orthopaedic Bioengineering | Biomaterials
Rob's research program focuses on the engineering of musculoskeletal tissues, with a particular focus on articular cartilage, the knee meniscus, and the intervertebral disc. His group uses rigorous mechanical and molecular analyses to understand the emerging functional properties of engineered tissues, to precisely define the criteria and routes toward 'success' from native tissue structure and function, and to focus technology development on improving these critical features in engineered constructs. Specifically, this work employs adult mesenchymal stem cells, custom mechanobiologic culture conditions, and novel scaffolding technologies to enhance and direct functional tissue development.
PhD Biomedical Engineering 2003 - Columbia University
- Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss, Bonnevie, E.D. | Gullbrand, S.E. | Ashinsky, B.G. | Tsinman, T.K. | Elliott, D.M. | Chao, P.-H.G. | Smith, H.E. | Mauck, R.L., Nature Biomedical Engineering, 2019
- Recombinant human fgf18 preserves depth-dependent mechanical inhomogeneity in articular cartilage, Meloni, G.R. | Farran, A. | Mohanraj, B. | Guehring, H. | Cocca, R. | Rabut, E. | Mauck, R.L. | Dodge, G.R., European Cells and Materials, 2019
- Multiscale and multimodal structure–function analysis of intervertebral disc degeneration in a rabbit model, Ashinsky, B.G. | Gullbrand, S.E. | Bonnevie, E.D. | Mandalapu, S.A. | Wang, C. | Elliott, D.M. | Han, L. | Mauck, R.L. | Smith, H.E., Osteoarthritis and Cartilage, 2019
- Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix, Han, B. | Li, Q. | Wang, C. | Patel, P. | Adams, S.M. | Doyran, B. | Nia, H.T. | Oftadeh, R. | Zhou, S. | Li, C.Y. | Liu, X.S. | Lu, X.L. | Enomoto-Iwamoto, M. | Qin, L. | Mauck, R.L. | Iozzo, R.V. | Birk, D.E. | Han, L., ACS Nano, 2019
- A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering, Patel, J.M. | Wise, B.C. | Bonnevie, E.D. | Mauck, R.L., Tissue Engineering - Part C: Methods, 2019