Sydney Shaffer

Assistant Professor of Pathology and Laboratory Medicine and
Bioengineering (BE)

Email | Research Webpage


Honors and Awards:  Hartwell Postdoctoral Research Fellowship, Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research, NIH F30 Ruth L. Kirschstein National Research Service Award

Research Expertise: Cellular and Molecular Engineering | Systems and Synthetic Bioengineering | Cellular Imaging | Single-cell Biology | Epigenetics

Research in the Shaffer lab is focused on understanding how differences in single-cells can drive phenotypes such as drug resistance, oncogenesis, cell differentiation, and migration. By studying these processes at the single cell level, we have found tremendous cell-to-cell variability even in clonally derived cell lines and uniform environments. The Shaffer lab works to understand the etiology of single-cell variability and how it can enable individual cells to carryout important or deleterious functions in health and disease. We use a combined approach integrating high-throughput imaging, sequencing, and screening data to probe single-cell variability and its phenotypic consequences. We also leverage methods and approaches from single-cell biology to develop new diagnostic and prognostic assays for clinical use. Our long-term goal is to develop quantitative maps of cells and tissues and then manipulate single-cell variability towards improving human health.

Education:
BS Chemical Engineering - Georgia Institute of Technology - 2010
PhD Bioengineering - University of Pennsylvania - 2017
MD Perelman School of Medicine - University of Pennsylvania - 2018

Recent Publications


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