Kathryn Davis, MD

Dr. Davis is an Instructor of Neurology at the University of Pennsylvania. She attended Brown University where she obtained a Bachelor of Science in Neuroscience.  She then graduated from Yale Medical School.  She completed medical internship, Neurology residency, and Epilepsy Fellowship at the University of Pennsylvania.  She currently has grant funding through both an Epilepsy Foundation grant and a KL2 NIH grant.  Her research interests including utilizing state of the art broadband intracranial EEG and neuroimaging to improve epileptic localization in neocortical epilepsy patients. 

She is currently looking at broadband frequency cutoffs and their effect on seizure localization.  She plans to forge a career as a clinician-investigator and will submit for a K23 award in 2010. 

Original Research

1. Davis KA, Sturges B, Vite CH, Ruedebusch V, Worrell G, Gardner A, Chamberlain A, Leyde K, Sheffield WD, Litt B. (2010) Recording and analyzing continuous intracranial EEG in ambulatory epileptic dogs. Submitted to Annals of Neurology.

2. Blumenfeld H, Rivera M, McNally KA, Davis K, Spencer DD, Spencer SS.  (2004). Ictal neocortical slowing in temporal lobe epilepsy.  Neurology 63: 1015-1021. PMID: 15452292

3. Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ, Zubal IG, Spencer SS.  (2004). Positive and negative network correlations in temporal lobe epilepsy.  Cerebral Cortex, 14(8): 892-902. PMID: 15084494

Non-experimental articles

Anderson CT, Davis KA, Baltuch G. (2009) An update on brain stimulation for epilepsy. Current Neurology and Neuroscience Reports, 9(4): 1528-1542. PMID: 19515286

Davis KA, Cantor C, Maus D, Herman ST (2008) A Neurological Cause of Recurrent Choking During Sleep. Journal of Clinical Sleep Medicine, 4(6): 586-587. PMID: 19110889

Book chapters

Davis K, Herman ST. (2008) How Should Status Epilepticus Be Managed? Evidence-Based Practice of Critical Care. Deutschman & Neligan (Editors). Elsevier.


Davis K.A., Levine J., LeRoux P., Herman S. (2008) Clinical Utility of Graphical Displays of Continuous EEG for Detection of Cerebral Infarction or Vasospasm after Subarachnoid Hemorrhage. AES meeting abs., 2.067. Online at http://www.aesnet.org/

Marfeo, A. T., Yu, L., Gordon, A., Agarwal, R., Ellens, D. J, Golomb, J. D., Shamy, M., Levin, A. R., Davis, K. A., McNally, K., Vives, K., Spencer, D., Spencer, S.,  Schevon, C.,  Zaveri, H., Blumenfeld, H. (2008) Intracranial EEG Quantitative Analysis and Behavioral Impairment in Temporal Lobe Epilepsy. AES meeting abs., 1.045. Online at http://www.aesnet.org/

Marfeo A., Yu L., Gordon A., Agarwal R., Ellens D.J., Golomb J.D., Shamy M., Levin A.R., Davis K., McNally K.A., Vives K., Spencer D.D., Spencer S.S., Schevon C., Zaveri H., Blumenfeld H. (2008) Quantitative analysis of intracranial EEG changes associated with impaired consciousness in temporal lobe seizures. Soc. Neurosci. Abs.

McNally KA, Venderhill SD, Paige AL, Doernberg S, Chung, R, Adamiak K, Novotny EJ, Zubal IG, Spencer SS, Blumenfeld H (2003). Network mechanisms for loss of consciousness in temporal lobe epilepsy. Soc. Neurosci. Abs., Online at http://web.sfn.org/

McNally KA, Venderhill SD, Paige AL, Doernberg S, Chung, R, Adamiak K, Novotny EJ, Zubal IG, Spencer SS, Blumenfeld H (2003). Excitatory and inhibitory network interactions during loss of consciousness in temporal lobe epilepsy. Epilepsia (AES meeting abstracts). 44

Blumenfeld H, Vanderhill S, Ahoya L, Chung R, Adamiak K, Paige L, Corsi M, Novotny EJ, Zubal IG, Spencer SS (2002). Cortical and Subcortical Networks in Human Temporal Lobe Seizures. Soc. Neurosci. Abs., 796.2. Online at http://web.sfn.org/

Research Support

Epilepsy Foundation of America, Research and Training Fellowship for Clinicians

Davis (PI)    1/2009-12/2011

Does High Frequency Intracranial EEG Improve Seizure Localization?

The goal of this study is to determine if higher bandwidth recording can improve localization of seizures and outcome from epilepsy surgery, and improve the accuracy of implantable devices to treat epilepsy.

Role: PI

The University of Pennsylvania, The Institute of Translational Medicine and Therapeutics (ITMAT) Institutional Clinical and Translational Science Award (KL2)

Davis (PI)7/2009-7/2011

Does High Frequency Intracranial EEG Improve Seizure Localization?

The goal of this grant is to provide rigorous training in translational medicine and clinical trials, which will result in the acquisition of a Master’s in Translational Research.  Education and guidance received through this masters program has provided the opportunity to expand research in neuroimaging as it relates to epilepsy.

Role: PI 

MRI-PET coregistration: iEEG ictal data correlated with hypoperfusion evident on MRI-PET coregistration (right) in the right frontal region (see arrows). T1 MRI (left) and PET (middle) had no identified abnormalities, The patient underwent surgical resection of the right frontal region and is now seizure free.

Broadband macroelectrode iEEG: One second clips capturing preictal and ictal spikes illustrating the presence of high frequency oscillations at a 500 Hz cutoff that are not apparent at a 100 Hz cutoff, which is the cutoff used currently in clinical practice.