Education:

Rutgers College -- Rutgers, The State University of New Jersey

B.A. 2000 Molecular Biology &Biochemistry; Psychology and Behavioral Neuroscience; Cognitive Science

Dartmouth Medical School, Hanover, NH

M.D., 2004

Lahey Clinic Medical Center, Burlington, MA

Internal Medicine Preliminary Year Residency, 2004-2005

Tufts Medical Center, Boston, MA

Adult Neurology Residency, 2005-2008

Hospital of the University of Pennsylvania, Philadelphia, PA

Epilepsy, Clinical Neurophysiology Fellowship, 2008-present

University of Pennsylvania, School of Medicine, Philadelphia, PA

MS Clinical Epidemiology (and Biostatistics), 2009-present

Dr. Mani is an adult neurologist and clinical research fellow in the Department of Neurology (Epilepsy Division) at the Hospital of the University of Pennsylvania.  He is also a student in the Master of Science in Clinical Epidemiology program at the UPenn School of Medicine; he is supported by a NIH T32 grant.

Dr. Mani’s research interests are in neurophysiologic monitoring of critically-ill patients, epilepsy patients, and in other patients prone to frequent seizures.  They also include developing and assessing methods to determine the most efficient use of technology in neurologic diagnosis and treatment, specifically patients prone to developing acute seizures.  Additionally, they include evaluation of acute symptomatic factors associated with development of acquired adult-onset epilepsy that promote frequent seizures.

Dr. Mani collaborates with scientists of the Litt Neuroengineering Laboratory in the development of automated detectors of epileptiform activity to reliably measure these signals in critically-ill patients undergoing continuous EEG monitoring.  Specifically, this is being tested on comatose patients immediately after cardiac arrest treated with therapeutic hypothermia.  Additionally, Dr. Mani is characterizing the scalp EEG patterns of these post-arrest patients to describe the epidemiology and timing of epileptiform activity and its association with clinical seizure activity.  He is also determining reliable ways to use these and other EEG patterns to assist in prognostication and subselecting patients for other experimental neuroprotective therapies.

Publications (as of 2010-04):

Mani R, Pollard JR. Antiepileptic drugs and other medications: what interactions may arise?   Curr Treat Options Neurol, 11(4): 253-61, July 2009.

Vytopil M, Mani R, Adlakha A, Zhu J.  Acute chorea and hyperthermia after concurrent use of modafinil and monoamine oxidase inhibitor.  American Journal of Psychiatry, 164: 684, April 2007.

Abstracts:

Frechette E, Mani R, Dalmau J, Schmitt S.  Novel EEG featurs of anti-NMDA receptor encephalitis. American Clinical Neurophysiology Society national meeting, 2010, San Diego, CA.

Mani R, Schmitt S, Gaieski D, Litt B. Continuous EEG features and electrographic seizures are associated with outcome in adult cardiac arrest patients undergoing therapeutic hypothermia. Epilepsia 0 Suppl. 0 (Abst. 1.038 ), 2009 [American Epilepsy Society national meeting, Boston, MA].

Schmitt S, Mani R. Clinical features associated with electrographic seizures in patients placed on continuous EEG monitoring in the ICU. Epilepsia 0 Suppl. 0 (Abst. 1.133 ), 2009 [American Epilepsy Society national meeting, Boston, MA].

Book Sections:

Mani R & Cosgrove, GC.  Surgical resection of the central cortex.  In Operative Techniques in Epilepsy Surgery. Eds. Baltuch GH and Villemure JG.  2008. Thieme Medical Publishers.