Susan S. Margulies

George H. Stephenson Term Professor
Bioengineering (BE)

Email | Research Webpage

Honors and Awards:  ALA Young Investigator Award, Whitaker Foundation Young Investigator Award, NSF CAREER Award, Stapp Car Crash Conference Award, S Reid Warren Award for Distinguished Teaching, Ford Motor Company Award for Faculty Advising, American Society of Mechanical Engineering Award, Association of Women in Science Elizabeth Bingham Award for the Advancement of Women in Science, Fellow - American Institute for Medical and Biological Engineering - 2006, Fellow - American Society of Mechanical Engineers - 2009, Fellow - Biomedical Engineering Society - 2009

Research Expertise: Biomechanics | Cell Mechanics | Tissue Engineering

Cells within the body routinely tolerate deformations during activities such as head turning and breathing, yet when cells are deformed beyond a safe limit or injury threshold, function and structure are altered temporarily or even permanently. The goal of the Injury Biomechanics Lab is to determine functional and structural injury thresholds in the brain and lung, and use them to understand mechanisms of traumatic brain and lung injury. In addition, the lab's study of the biochemical and molecular biology of injured cells facilitates the development of preventive and therapeutic measures. Because human tissues tend to be inhomogeneous, anisotropic and nonlinear, and the tissues of interest undergo large strains, determining the complex relationship between cellular and macroscopic responses requires an integrated biomechanics approach consisting of several simultaneous rigorous engineering experimental and theoretical analyses. Tissue mechanical properties and injury thresholds are measured and used to develop computational models. These models are used to generalize our experimental cell and tissue findings and determine macroscopic injury mechanisms. Applications of current work are in the areas of traumatic head injury in adults and children, and ventilator-induced lung injury. These studies parallel clinical investigations regarding the treatment and detection of traumatic injury. Margulies' research program is currently funded by NIH and CDC. She has served or is on the editorial boards of the Journal of Physiology, the Journal of Biomechanical Engineering, the Journal of Biomechanics, and the Journal of Neurotrauma; she has served on grant review panels for NSF, NIH, and CDC, and is chair of the NIH RIBT study section. Her work has been featured in The New York Times, Forbes, Atlanta Journal-Constitution, Discover Magazine, and by CNN and the BBC. Margulies also serves as Vice-President of the Penn Forum for Women Faculty and Past Chair of the University of Pennsylvania Faculty Senate.

Education:
PhD Bioengineering 1987 - University of Pennsylvania
MSE Bioengineering 1983 - University of Pennsylvania
BSE Mechanical & Aerospace Engineering 1982 - Princeton University


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