Design of antiseizure stimuli for an implantable device

Computational modeling of HFOs

Quantitative analysis of high frequency EEG recordings


Brigham Young University B.S. Electrical Engineering 1995

Case Western Reserve University Ph.D. Biomedical Engineering 2000 M.D. 2002

University Hospitals of Cleveland Resident in Neurology 2006

Hospital of the University of Pennsylvania Fellowship, Epilepsy 2008


Recent papers:

  1. 1.Stacey WC, Lazarewicz, MT, and Litt B. Synaptic noise and physiological coupling generate high-frequency oscillations in a hippocampal computational model.  J Neurophysiol 2009 102:2342.  PMID: 19657077

  2. 2.Stacey WC and Litt B. Technology Insight: neuroengineering and epilepsy-designing devices for seizure control. Nature Clin Pract Neurol.  2008 4:190. PMID 18301414

Earlier papers:

   1. Block BM, Stacey WC, and Jones SW. Surface charge and lanthanum block of calcium current in bullfrog sympathetic neurons. Biophys J 1998 May; 74(5) 2278-84. pmid:9591655.

   2. Stacey WC and Durand DM. Stochastic resonance improves signal detection in hippocampal CA1 neurons. J Neurophysiol 2000 Mar; 83(3) 1394-402. pmid:10712466.

   3. Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, and Durand DM. Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol 2001 Feb 15; 531(Pt 1) 181-91. pmid:11179402.

   4. Stacey WC and Durand DM. Synaptic noise improves detection of subthreshold signals in hippocampal CA1 neurons. J Neurophysiol 2001 Sep; 86(3) 1104-12. pmid:11535661.

   5. Stacey WC and Durand DM. Noise and coupling affect signal detection and bursting in a simulated physiological neural network. J Neurophysiol 2002 Nov; 88(5) 2598-611. doi:10.1152/jn.00223.2002 pmid:12424297.

   6. Lian J, Bikson M, Sciortino C, Stacey WC, and Durand DM. Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro. J Physiol 2003 Mar 1; 547(Pt 2) 427-34. doi:10.1113/jphysiol.2002.033209 pmid:12562909.

   7. Yang K, Guo Y, Stacey WC, Harwalkar J, Fretthold J, Hitomi M, and Stacey DW. Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels. BMC Cell Biol 2006 Aug 30; 7 33. doi:10.1186/1471-2121-7-33 pmid:16942622.

Bill Stacey, MTR, MD, PhD