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PhD., Applied Mechanics
California Institute
of Technology, Pasadena,
California, 2002.
M.S., Applied Mechanics
California Institute
of Technology, Pasadena,
California, 1998.
B.
Tech., Mechanical Engineering
Indian Institute of
Technology, New Delhi,
India, 1997.
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I am interested in problems
at the interface of mechanics,
physics and biology. The mechanics
of DNA is one such subject where
the Kirchhoff theory of filaments
can be used to describe not
just the behaviour of DNA at small scales but also
its implications on the life
cycle of viruses and the switching
on and off of genes. Understanding
the effects of thermal fluctuations
in this context is a major thrust
of my research. I am also interested
in biological applications of
the mechanics of lipid membranes
and the mechanics of material
interfaces in slender bodies.
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1. Andre E. X. Brown, Rustem I, Litvinov, Dennis E. Discher, Prashant K. Purohit, John W. Weisel, “Multiscale mechanics of fibrin polymer: Gel stretching with protein unfolding and loss of water”, Science Vol. 325. no. 5941, pp. 741 - 744, (2009).
2.Tianxiang Su, Somes K. Das, Ming Xiao, Prashant K. Purohit, "Transition between two regimes describing internal fluctuation of DNA in a nanochannel",PLoS One Vol. 6, e16890, (2011).
3. Tianxiang Su and Prashant K. Purohit, “Mechanics of forced unfolding of proteins”, Acta Biomaterialia 5, 1855-1863, (2009).
4. Prashant
K. Purohit and Philip C. Nelson,
"Effect
of supercoiling on formation
of protein mediated DNA loops",
Phys.
Rev. E 74, 061907 (2006).
5. Prashant K. Purohit, Jane
Kondev and Rob Phillips, "Mechanics
of DNA packaging in viruses",
Proc. Natl. Acad. Sci. 100(6),
3173-3178 (2003).
6. Prashant K. Purohit and
Kaushik Bhattacharya, "Dynamics
of strings made of phase transforming
materials",
J. Mech. Phys. Solids 51,
393-424 (2003).
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