Matt Good

Assistant Professor of Cell and Developmental Biology and
Bioengineering (BE)

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Honors and Awards:  Charles E. Kaufman New Investigator Award, March of Dimes Basil O’Connor Scholar Award, McCabe Fund Fellow Award, Burroughs Wellcome Fund Career Award at the Scientific Interface

Research Expertise: Synthetic Biomaterials | Disordered Protein Assemblies | Synthetic Cell Biology | Cellular Engineering | Artificial Cells | Transcriptional Imaging | Cell Size Sensors

The Good lab is interested in engineered control of cell behaviors, design of synthetic materials and organelles within cells, and reconstitution of biological processes in cell-like compartments ex vivo. A major focus of our group is construction of biomimetic compartments from nanometer to micrometer length scales for applications in synthetic biology, cell biology and drug delivery. For example, we utilize disordered proteins that undergo self-assembly or coacervation to form mesoscale protein condensates, as a designer membraneless organelles. Additionally, we study compartmentalization at the micron length scales, using microfluidics to form synthetic cell-size compartments and to test how physical boundary conditions regulate subcellular processes in a cell. Our lab leverages microfabrication and microfluidic strategies along with optochemical tools and protein design to build these bioinspired materials. A second thrust of the lab is to develop tools for transcriptional imaging to measure genome activation during embryogenesis in whole mount embryos. We have developed a methodology that enables quantitation of large-scale zygotic transcription in a variety of model systems. We are combining this toolkit with genetic knockouts to investigate fundamental questions in early development, including how embryos measure and count. A third project in the lab is design and construction of cell volume sensors for determining the contribution of cell size dysregulation to disease progression. In collaboration with the Penn Biobank we are investigation how loss of cell size control correlates with development and progression of multiple types of cancer.

Member of:

PhD Biochemistry - University of California - San Francisco - 2010
BA Biochemistry - University of California - Berkeley - 2003

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