I'm interested in questions in evolutionary biology, and I leverage both mathematics and experiments to better understand how organisms function, adapt, and evolve.

Here's a selection of some of my research projects. For a current and complete list of publications, see my Google Scholar profile.

I'm using DNA-barcoded evolution experiments across multiple environments in several genetic backgrounds to understand how additional mutational steps affect observed tradeoffs in short-term evolution.

This project is in progess and is close collaboration with Yuping Li, Gavin Sherlock, and Dmitri Petrov.

How well can we measure fitness? What are the barriers to our ability to measure this important parameter? And how can we make sense of large amounts of variation between replicate experiments despite low levels of technical noise?
Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch (bioRxiv 2022)
with several members of the Geiler-Samerotte lab, Dmitri Petrov, and Kerry Geiler-Samerotte.

Do adaptive mutations affect a small number of traits or many? We measured the fitness of adaptive yeast mutants across a series of subtle environmental perturbations, finding that the answer is both, if you consider how phenotypes contribute to fitness in environments near or far from where they evolved.
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation. (2020)
with Kerry Geiler-Samerotte and Dmitri Petrov.