Principle Investigator

David F. Meaney, Ph.D.

Solomon R. Pollack Professor and Chair of Bioengineering


BSE in Biomedical Engineering, Rensselaer Polytechnic Institute, 1987
MSE, 1989 and Ph.D., 1991, in Bioengineering, The University of Pennsylvania


  • Understanding mechanical cues that regulate CNS injury and repair
  • Multiscale integration of mechanical injury response from synaptic spines to neural networks
  • Mechanisms of network dysfunction and therapeutic targets for repair




Post-Doctoral Fellows

Matthew A. Hemphill, Ph.D.Publications

BS in Biomedical Engineering, Washington University in St. Louis, 2008
Ph.D. in Bioengineering, Harvard University, 2014


  • Understanding functional effects of traumatic brain injury on neural networks using both in vitro and in vivo injury models
  • Understanding the mechanosensitive properties of neurons and neuronal networks

Rosalind E. Mott, Ph.D.Publications

BS in Biomedical Engineering, Johns Hopkins University, 1999
Ph.D. Biomedical Engineering, University of Virginia, 2008


  • Cell adhesions, cytoskeleton and their role in mechanotransduction.
  • Mechanisms of local mRNA translation.
  • The impact of injuryd on mRNA translation and synaptic plasticity.
  • The interplay between network activity and synaptic plasticity.

Shanti Tummala, Ph.D.Publications

Ph.D. in Biomedical Engineering, Illinois Institute of Technology, 2009


  • Electrophysiological assessment of neural circuits after injury.

Ph.D. Candidates

Alexandra AdegokePublications

BS in Engineering Science, Smith College, 2010
MSc in Biomedical Engineering, University of Oxford, 2011
MD/PhD candidate, University of Pennsylvania


  • Understanding traumatic brain injury and recovery via neural microcircuit analysis
  • The impact of injury on network activity in vitro.

Laura WilesPublications

BS in Bioengineering, Clemson University, 2012
Ph.D. student, University of Pennsylvania
NSF Graduate Research Fellow


  • Understanding traumatic brain injury and recovery using in vitro models
  • STEM outreach and education

Masters Candidates

Leon WuPublications

BS in Biology, St. John's University, 2011
MS candidate, University of Pennsylvania, 2014


  • Develop an exosome-based diagnostic for TBI by simulating TBI using mechanical and chemical injuries on cells in-vitro.

Research Specialists

Julia Valenziano

BA in Biological Basis of Behavior, University of Pennsylvania, 2013


  • The role of mTOR signaling in traumatic brain injury
  • Effect of blast injury on neuronal networks

Undergraduate Research Assistants

  • Shichao (Bioengineering, 2016)
  • Chang Su (Bioengineering, 2016)

Lab Alumni

  • YungChia Chen, Ph.D., American Society for Engineering Education Post-doctoral Fellow, Naval Research Laboratory
  • Tapan Patel, M.D.,Ph.D., University of Michigan, Ophthalmology
  • Katie Kopil, Ph.D., Associate Director, Research Programs The Michael J. Fox Foundation for Parkinson's Research
  • Anthony Choo, Ph.D., Senior Scientist, PsychoGenics
  • Jenn Singh, Ph.D., Research fellow at University of Pennsylvania (Eberwine lab)
  • Catherine von Reyn, Ph.D., Post-Doctoral fellow at Janelia Farms HHMI (Card lab)
  • Pallab Singh, Ph.D., Patent Agent, Riverside Law firm
  • Mahlet Mesfin, Ph.D., AAAS Fellow, Office of Science, Technology and Policy, The White House
  • Vineet Tiruvadi, B.S./M.S., Emory/Georgia Tech (MD/PhD candidate)
  • Adam Hockenberry, B.A., Northwestern University (Ph.D. candidate)
  • Bill Miller, Ph.D., Swiftwater Group
  • Dave Shreiber, Ph.D., Rutgers University (Professor of Biomedical Engineering)
  • Donna Geddes-Klein, Ph.D., Senior Scientist, Janssen Pharmaceuticals
  • Mike DeRidder, Ph.D., Director, R&D Customer Insights, GlaxoSmithKline
  • Theresa Lusardi, Ph.D., Research Faculty, Legacy Health Science Institute, Portland, OR