Institute for Medicine and Engineering
University of Pennsylvania
Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104
B.S. Chemistry, New York University, 2003
B.E. Chemical Engineering, Stevens Institute of Technology, 2003
M.S. Chemical and Biomolecular Engineering, University of Pennsylvania, 2005
1) In the development of microarray-based enzyme bioassays, most approaches use pins for contact spotting. Acoustic dispensing is a new technology capable of nanoliter dispensing by utilizing focused acoustic energy to eject a liquid sample from an open source well. This method avoids drawbacks of undesired physical contact of pins with biological samples, difficulty in assembling multicomponent reactions by readdressing, a rigid mode of printing operation that lacks flexibility, and time consuming wash steps needed for pin tools. Microarray platforms are becoming increasingly widespread as a tool for genomic, proteomic, and enzymatic applications.
2) Organometallic compounds have shown promise as selective inhibitors of kinases (Bregman, Carroll, and Meggers, JACS, 2005). In collaboration with the Department of Chemistry, we have worked toward screening and optimizing libraries of ruthenium-based compounds to act as highly potent and selective inhibitors of important kinases using SAR approaches.